Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 3621-81-6, molecular formula is C7H3Cl2NO, introducing its new discovery. 3621-81-6
DERIVATIVES OF HETEROARYLSULFONAMIDES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPY
The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1 -C4 alkyl, or linear or branched C1 -C4 alkoxy, represents oxygen or sulphur, B represents nitrogen when n= 1 or 2 and D represents -C(=O)-, or B represents CH when n=0 and D represents -CH2O- or when n=1 and D represents -O-, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1 -C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem