Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 108-32-7, Name is 4-Methyl-1,3-dioxolan-2-one, molecular formula is , belongs to benzoxazole compound. In a document, author is Pattarawarapan, Mookda, Name: 4-Methyl-1,3-dioxolan-2-one.
Metal-Free Synthesis of 2-N,N-Dialkylaminobenzoxazoles Using Tertiary Amines as the Nitrogen Source
The unprecedented reaction of tertiary amines with 2(3H)-benzoxazolones has been investigated. In the presence of the Ph3P-I-2 reagent system, the reaction of both acyclic and cyclic aliphatic tertiary amines led to the formation of 2-N,N-dialkylaminobenzoxazoles with the selective cleavage of an alkyl group. Especially, N-(2-iodoethyl)piperazinyl derivatives were rapidly produced in good yields when using DABCO as the nitrogen source. Only in the cases when the nucleophilicity of the substrates exceeds that of the amine, competitive self -condensation of benzoxazolones then proceeds preferentially. P-31{H-1}-NMR study suggested the involvement of an aryloxyphosphonium intermediate and/or possibly 2-iodobenzoxazole which activates the C-2 position of benzoxazolones toward nucleophilic aromatic substitution.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-32-7, in my other articles. Name: 4-Methyl-1,3-dioxolan-2-one.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem