1750-45-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1750-45-4, Name is 5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one, molecular formula is C7H4ClNO3. In a article£¬once mentioned of 1750-45-4
The effect of vehiculum and age on serum chlorzoxazone concentration in the rat
The xenobiotic absorption process is dependent on many factors, related both to the substance and form of its administration. During administration of small amounts of drugs, the effect of vehiculum on drug fate in the body becomes also evident. The intensity of absorption depends on numerous factors not necessarily related to the substance and its formulation, and also to biotransformation and active transport processes. Additional problem is the fact that many medicines are lipophilic compounds and insoluble in the water (e.g., chlorzoxazone). Methanol and its aqueous solutions facilitate administration to the experimental animals, in the dissolved form of a number of medicines practically insoluble in water. Taking into consideration that methanol is particularly for rats, of low toxicity, it is quite frequently applied as vehiculum. The aim of this study was to determine the bioavailability of chlorzoxazone depending on the vehiculum and observe whether the impact of vehiculum changes over the age of animals. The study was performed on male Wistar rats. The tests were performed using chlorzoxazone, which is recognized as biomarker of CYP2E1 isoform activity. As a compounds modulating metabolism of the chlorzoxazone, carbon tetrachloride was used, and quinidine as an inhibitor of P-glycoprotein, CYP2D and CYP3A. Various procedures of chlorzoxazone administration were tested, including solubilization in methanol, suspension in 1% water solution of carboxymethyl cellulose and dissolution in alkalized solution of 0.9% NaCl. The results of this study show that methanol influences the chlorzoxazone bioavailability and kinetics When chlorzoxazone was administered in methanol, the AUC0-5h increased seven times compared to the administration in 1% of carboxymethyl cellulose. There are significant changes in the bioavailability of chlorzoxazone in rats between the second and fifth month of life.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 1750-45-4, In my other articles, you can also check out more blogs about 1750-45-4
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem