Recommanded Product: 2-Ethylbenzo[d]oxazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Inhibitors of hepatic mixed function oxidases. V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives. Author is Little, Peter J.; Ryan, Adrian J..
All of a series of 12 benzoxazoles tested inhibited aminopyrine N-demethylase (I) activity of rat liver microsomes from phenobarbitone-treated rats, and there was an apparent relation between inhibitory potency and partition coefficient For the 2-alkylbenzoxazole series, inhibitory potency towards I activity increased as the number of C atoms in the alkyl side chain increased. Substitution of a Me group into the 2 or 5 position of the benzoxazole nucleus produced a 2- to 3-fold increase in inhibitory potential for each instance. Eleven of the benzoxazoles enhanced aniline p-hydroxylase activity in rat liver microsomes, whereas one, zoxazolamine, was inhibitory; no relation was apparent between physicochem. properties and degree of enhancement of aniline p-hydroxylase activity.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem