As a common heterocyclic compound, it belongs to benzoxazole compound, name is 2-Benzoxazolinone, and cas is 59-49-4, its synthesis route is as follows.
70% Nitric acid (50?mL, 0.80?mol) was cooled to 0?C and 3H-1,3-benzoxazol-2-one (5.00?g, 37?mmol) was added. The reaction mixture was stirred at rt for 4?h and then poured in ice.The resulting precipitate was collected by filtration, washed with water and dried to give a pink solid (5.80?g, 32.5?mmol, 87%). Mp?>?250?C. 1H NMR (300?MHz, DMSOd6): delta 12.41 (s, 1H), 8.20 (d, J?=?2.2?Hz, 1H), 8.13 (dd, J?=?8.6?Hz, J?=?2.2?Hz, 1H), 7.28 (d, J?=?8.6?Hz, 1H).13C NMR (300?MHz, DMSOd6): delta 154.7, 143.2, 142.5, 137.2, 121.2, 109.8, 105.8. LCMS m/z calc for [M?-?H]+: 179.0, found: 179.0.
59-49-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,59-49-4 ,2-Benzoxazolinone, other downstream synthetic routes, hurry up and to see
Reference£º
Article; Gay, Marion; Evrard, Caroline; Descamps, Florian; Carato, Pascal; Renault, Nicolas; Coevoet, Mathilde; Eddarkaoui, Sabiha; Baud, Catherine; Larchanche, Paul-Emmanuel; Buee, Luc; El Bakali, Jamal; Vingtdeux, Valerie; Sergeant, Nicolas; Melnyk, Patricia; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 104 – 125;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem