On July 11, 2016, Ono, Masahiro; Kobayashi, Tsuneyuki; Yamazaki, Ryuta; Haibara, Hirotaka; Nishiyama, Yukiko; Hohashi, Atsuko; Nishiyama, Hiroyuki; Kurita, Akinari; Matsuzaki, Takeshi; Kono, Kimitoshi; Izumi, Hiroto published a patent.Name: Methyl benzo[d]oxazole-7-carboxylate The title of the patent was Preparation of heteroaryl compounds as ZNF143 inhibitors. And the patent contained the following:
Title compounds A-B-C-D [A = H, CH3, naphthalen-1-yl, etc.; B = -CC-; C = -CONH-, -CON(CH3)- or 1,3,4-oxadiazole-2,5-diyl; D = (un)substituted Ph or monocyclic heteroaryl containing N or S; or C and D may combine to form (un)substituted benzoxazol-2-yl, benzothiazol-2-yl, benzimidazol-2-yl, etc.; or salts thereof], useful for the treatment of cancer, were prepared For example, to a suspension of 3-phenylpropiolic acid (1.27 mmol) in CH2Cl2 (1.9 mL) were added oxalyl chloride (1.33 mmol) and DMF (1 drop), the resulting mixture was stirred at room temperature for 2 h and treated with 2-amino-4-chlorobenzonitrile (1.27 mmol) [room temperature, overnight] to give, after work-up, compound I (75.2% yield). The invention compounds, e.g., II, showed selective inhibition activity for ZNF143 over SV40 promotor. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Name: Methyl benzo[d]oxazole-7-carboxylate
The Article related to aromatic heterocycle preparation znf143 inhibitor, cancer treatment aromatic heterocycle znf143 inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: Methyl benzo[d]oxazole-7-carboxylate
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem