100-200 | Page 2 of 10 | Heterocyclic Building Blocks-Benzoxazole

Ge, Jian-Feng et al. published their research in MedChemComm in 2012 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Electric Literature of C9H9NO

Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities was written by Ge, Jian-Feng;Zhang, Qian-Qian;Lu, Jian-Mei;Kaiser, Marcel;Wittlin, Sergio;Brun, Reto;Ihara, Masataka. And the article was included in MedChemComm in 2012.Electric Literature of C9H9NO This article mentions the following:

Six cyanine dyes (including sym. and unsym. trimethine and pentamethine cyanine dyes with substituted benzoxazolyl or benzothiazolyl groups), were synthesized and evaluated for their in-vitro antiprotozoal activities against Plasmodium falciparum K1, Trypanosoma cruzi, Trypanosoma brucei rhodesiense and Leishmania donovani. Several trimethine cyanine dyes containing benzothiazole groups exhibited strong activity against Plasmodium falciparum and Trypanosoma cruzi, while one sym. pentamethine cyanine containing a fluorinated benzothiazolyl group was highly active against Trypanosoma brucei rhodesiense. The title compounds thus formed included a benzothiazole-benzothiazolium derivative (I) [[(benzothiazolylidene)pentadienyl]benzothiazolium salt, pentamethine compound] and related compounds and benzoxazole analogs. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mayo, Muhammad Shareef et al. published their research in Journal of Organic Chemistry in 2014 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.COA of Formula: C9H9NO

Synthesis of Benzoxazoles from 2-Aminophenols and β-Diketones Using a Combined Catalyst of Bronsted Acid and Copper Iodide was written by Mayo, Muhammad Shareef;Yu, Xiaoqiang;Zhou, Xiaoyu;Feng, Xiujuan;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Journal of Organic Chemistry in 2014.COA of Formula: C9H9NO This article mentions the following:

Cyclization reactions of 2-aminophenols with β-diketones catalyzed by a combination of Bronsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as Me, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Lozynski, Marek et al. published their research in Polish Journal of Chemistry in 1990 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Electric Literature of C9H9NO

Mass spectra of some dialkylbenzoxazoles and 1,2-benzisoxazoles was written by Lozynski, Marek;Krzyzanowska, Ewa;Matecka, Dorota. And the article was included in Polish Journal of Chemistry in 1990.Electric Literature of C9H9NO This article mentions the following:

The mass spectra of several 3,5-dialkyl-1,2-benzisoxazoles and isomeric 2,5-dialkylbenzoxazoles have been measured. The fragmentation of di-Me derivatives has been considered to proceed via an iso-π-electronic structure with the azulene ion, taking into account that the cleavage of the N-O linkage followed by carbon monoxide expulsion is prefered. For all 5-alkyl isomers, rupture of the benzylic C-C bond is predominant. If a long alkyl substituent is present in the heterocyclic ring, intensive peaks due to the McLafferty rearrangement as well as to γ-cleavage are observed Fragmentation of compounds containing an aliphatic chain in different positions in relation to nitrogen gives the possibility of determining the structure of the heterocyclic ring. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tehrani, Kourosch Abbaspour et al. published their research in Journal of Agricultural and Food Chemistry in 2002 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 5676-58-4

Thermal Degradation Studies of Glucose/Glycine Melanoidins was written by Tehrani, Kourosch Abbaspour;Kersiene, Milda;Adams, An;Venskutonis, Rimantas;De Kimpe, Norbert. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Application of 5676-58-4 This article mentions the following:

Nondialyzable and water-insoluble melanoidins, isolated from a glucose/glycine model reaction mixture, which was prepared in a standardized way according to the guidelines of the COST Action 919, were heated at different temperatures ranging from 100 to 300 °C. Among the volatile compounds, which were analyzed by solid-phase microextraction and GC-MS, pyrazines, pyridines, pyrroles, and furans were detected. In general, total amounts of volatile compounds increased with the temperature When water-insoluble melanoidins were heated, especially at higher temperatures, this resulted in a higher diversity of isolated compounds For furans, pyrroles, pyrazines, and carbonyl compounds, a maximum was observed in the case of high mol. weight melanoidins around 200-220 °C. Pyridines and total oxazoles, however, were generated in higher yields with increasing temperatures Thus, the possibility of producing some flavor-significant volatiles from heated standard melanoidins at temperatures relevant to food preparation and contribute to the flavor aspects originating from melanoidins. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zhang, Xiaohui et al. published their research in Tetrahedron in 2015 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2,5-Dimethylbenzoxazole

Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement was written by Zhang, Xiaohui;Huang, Ruofeng;Marrot, Jerome;Coeffard, Vincent;Xiong, Yan. And the article was included in Tetrahedron in 2015.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

A Beckmann-type rearrangement of o-hydroxy and o-aminoaryl N-H ketimines was developed to prepare benzoxazoles and N-Ts benzimidazoles, resp. The ketimine derivatives were easily prepared by condensation of ammonia with the corresponding ketones and (diacetoxyiodo)benzene acts as an efficient oxidant to trigger the [1,2]-aryl migration towards the formation of the desired heterocycles. Depending on the substitution pattern, the results revealed another mechanistic pathway through which benzisoxazoles or 1H-indazoles could be formed. The Beckmann-type rearrangement strategy was applied to the synthesis of benzimidazole-containing biorelevant targets such as chlormidazole and clemizole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Radanovic, Dusan J. et al. published their research in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Gold(III) complexes with imidazole, benzoxazole, purine and pyrimidine derivatives was written by Radanovic, Dusan J.;Matovic, Zoran D.;Ponticelli, Gustavo;Scano, Paola;Efimenko, Inessa A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.SDS of cas: 5676-58-4 This article mentions the following:

The synthesis and characterization of Au^III complexes with several heterocyclic ligands are reported. The compounds are [AuX₃(L)], where L = N-methylimidazole (N-MeIz), N-ethylimidazole (N-EtIz), N-propylimidazole (N-PrIz), benzoxazole (BO), 2-methylbenzoxazole (2-MeBO), 2,5-dimethylbenzoxazole (2,5-diMeBO), 2-aminopyrimidine (2-APm), 4(6)-hydroxypyrimidine [4(6)-hydrPm] or hypoxanthine (Hypox) and X = Cl or Br. Elemental anal., conductivity measurements and spectral studies were used for the characterization of the complexes. A square-planar geometry with N-bonded heterocyclic ligands is suggested. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Hung, Su-Chun et al. published their research in Analytical Biochemistry in 1996 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Related Products of 5676-58-4

Cyanine dyes with high absorption cross section as donor chromophores in energy transfer primers was written by Hung, Su-Chun;Ju, Jingyue;Mathies, Richard A.;Glazer, Alexander N.. And the article was included in Analytical Biochemistry in 1996.Related Products of 5676-58-4 This article mentions the following:

Energy transfer (ET) fluorescent primers are significantly superior to single dye-labeled primers for DNA sequencing and multiplex genetic analyses (Ju, J. et al., 1996). We describe here ET primers in which a donor chromophore with a large absorption cross section but a low fluorescence quantum yield is exploited to increase the Stokes-shifted fluorescence emission of acceptor dyes. The new ET primers have 3-(ε-carboxypentyl)-3′-ethyl-5,5′-dimethyloxacarbocyanine (CYA; ε_M⁴⁸⁸ ^nm 142,000 M^-1cm^-1) at the 5′-end as a common energy donor, and fluorescein or rhodamine derivatives (FAM, R6G, TAMRA, and ROX), attached to a modified thymidine 10 bases away within the primer sequence, as acceptors. With 488-nm excitation, the fluorescence emission intensity of these 4 ET primers is 1.4-24-fold stronger than that of the corresponding primers labeled only with the single acceptor dye. When compared with the corresponding ET primers with a fluorescein derivative (FAM; ε_M⁴⁸⁸ ^nm 60,000 M^-1 cm^-1) as donor, the fluorescence emissions of primers with CYA as donor and FAM, R6G, TAMRA, and ROX as acceptors are 0.8-, 1.0-, 1.7-, and 1.7-fold, resp., as intense. The low fluorescence quantum yield of the CYA donor resulted in distinct fluorescence signals for the DNA-sequencing fragments with much lower crosstalk between the 4 detection channels than that seen with ET primers based on a FAM donor. With single-stranded M13mp18 DNA as the template, the CYA ET primers provided DNA sequences on a 4-color capillary sequencer with 100% accuracy in the first 500 bases. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Related Products of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Matovic, Zoran D. et al. published their research in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.COA of Formula: C9H9NO

Gold(I) complexes of azoles was written by Matovic, Zoran D.;Radanovic, Dusan J.;Ponticelli, G.;Scano, P.;Efimenko, I. A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.COA of Formula: C9H9NO This article mentions the following:

(Di-Me sulfide)AuCl reacts with azoles to give adducts [LAuX]₂ [L = N-methylimidazole (N-MeIm), N-ethylimidazole (N-EtIm), N-propylimidazole (N-PrIm), 2-methylbenzoxazole (2-MeBO) and 2,5-dimethylbanzoxazole (2,5-diMeBO); X = Cl or Br] which were characterized analy. and spectroscopically, including ¹H-n.m.r.I.r. and Raman studies showed that the compounds were binuclear with bridging halogen atoms. A nitrogen-containing ligand was coordinated to nitrogen N(3) atom of the azole ring in monodentate fashion. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zdanovich, V. I. et al. published their research in Doklady Akademii Nauk SSSR in 1965 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Related Products of 5676-58-4

Transfer of the substituent effect in series of cis- and transcinnamic acids was written by Zdanovich, V. I.;Parnes, Z. N.;Kursanov, D. N.. And the article was included in Doklady Akademii Nauk SSSR in 1965.Related Products of 5676-58-4 This article mentions the following:

Potentiometric determination of dissociation constants was performed for the cis- and trans-cinnamic acids and their benzoic acid analogs in 49% EtOH at 25°. The following K × 10⁶ were found for: benzoic acids, trans-cinnamic acid and cis-cinnamic acids, resp. with indicated substituents: H 1.25; 1.05 (m. 135.2-5.7°); 2.79 (m. 67-8°); p-O₂N 12.0; –; –; m-O₂N 13.7; 3.82 (m. 205-6°); 6.40 (m. 159-9.5°); p-Cl 2.38; 2.00 (m. 249.5-9.8°); 4.09 (m. 112.8-14°); p-Br 3.65; 1.92 (m. 264.7-5.5°); 4.02 (m. 127.6-8.5°); p-MeO 0.68; 0.70 (m. 188-8.2°); 1.78 (m. 68.8-9.7°); p-H₂N 0.17; –; –; p-Me₂N –; 0.32 (m. 118-20°); –. The following Hammett reaction constants were determined: ester hydrolysis trans isomer 0.540; cis isomers 0.461; dissociation of the acids trans isomers 0.539; cis isomers 0.422. Transfer of the substituent effects is more effective in trans-cinnamic acids than in the cis isomers. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Yang, Ji et al. published their research in Yancao Keji in 2011 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Category: benzoxazole

Study on nonaqueous phase Maillard reaction of glucose/L-lysine model system was written by Yang, Ji;Yang, Liu;Gao, Tao;Wu, Yi-qin;Cao, Qiu-e. And the article was included in Yancao Keji in 2011.Category: benzoxazole This article mentions the following:

The thermogravimetric characteristics of glucose, L-lysine and their mixture were determined by thermogravimetry. The pyrolytic products of glucose and L-lysine mixture at 5 temperature ranges were analyzed by the combination of thermogravimetry, solid phase microextraction and gas chromatog.-mass spectrometry (TG-SPME-GC-MS). The effects of the proportion of glucose to L-lysine, and air flow on the yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine were investigated as well. The results showed that : (1) the activation energy of reaction of glucose/L-lysine model system was far lower than that of degradation on their own. There was an endothermic process at the early reaction stage. In the temperature range of 135 to 245°C weight loss started, the mixture lost about 40% of its weight (2) 39 Compounds were identified in pyrolytic products of the model system. Ketones and furfurals were the main products at 100 to 250°C. From 250 to 350°C, pyrazine, pyridine, pyrrole, oxazole, imidazole and other nitrogenous heterocyclic compounds were detected. And the important flavor compounds were produced started from 150°C. (3) The yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine culminated at air velocity of 200 mL/min and the mass ratio of glucose to L-lysine of 1:1. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Category: benzoxazole).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem