Tag: 100-200

Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement was written by Zhang, Xiaohui;Huang, Ruofeng;Marrot, Jerome;Coeffard, Vincent;Xiong, Yan. And the article was included in Tetrahedron in 2015.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

A Beckmann-type rearrangement of o-hydroxy and o-aminoaryl N-H ketimines was developed to prepare benzoxazoles and N-Ts benzimidazoles, resp. The ketimine derivatives were easily prepared by condensation of ammonia with the corresponding ketones and (diacetoxyiodo)benzene acts as an efficient oxidant to trigger the [1,2]-aryl migration towards the formation of the desired heterocycles. Depending on the substitution pattern, the results revealed another mechanistic pathway through which benzisoxazoles or 1H-indazoles could be formed. The Beckmann-type rearrangement strategy was applied to the synthesis of benzimidazole-containing biorelevant targets such as chlormidazole and clemizole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Transfer of the substituent effect in series of cis- and transcinnamic acids was written by Zdanovich, V. I.;Parnes, Z. N.;Kursanov, D. N.. And the article was included in Doklady Akademii Nauk SSSR in 1965.Related Products of 5676-58-4 This article mentions the following:

Potentiometric determination of dissociation constants was performed for the cis- and trans-cinnamic acids and their benzoic acid analogs in 49% EtOH at 25°. The following K × 10⁶ were found for: benzoic acids, trans-cinnamic acid and cis-cinnamic acids, resp. with indicated substituents: H 1.25; 1.05 (m. 135.2-5.7°); 2.79 (m. 67-8°); p-O₂N 12.0; –; –; m-O₂N 13.7; 3.82 (m. 205-6°); 6.40 (m. 159-9.5°); p-Cl 2.38; 2.00 (m. 249.5-9.8°); 4.09 (m. 112.8-14°); p-Br 3.65; 1.92 (m. 264.7-5.5°); 4.02 (m. 127.6-8.5°); p-MeO 0.68; 0.70 (m. 188-8.2°); 1.78 (m. 68.8-9.7°); p-H₂N 0.17; –; –; p-Me₂N –; 0.32 (m. 118-20°); –. The following Hammett reaction constants were determined: ester hydrolysis trans isomer 0.540; cis isomers 0.461; dissociation of the acids trans isomers 0.539; cis isomers 0.422. Transfer of the substituent effects is more effective in trans-cinnamic acids than in the cis isomers. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Related Products of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Study on nonaqueous phase Maillard reaction of glucose/L-lysine model system was written by Yang, Ji;Yang, Liu;Gao, Tao;Wu, Yi-qin;Cao, Qiu-e. And the article was included in Yancao Keji in 2011.Category: benzoxazole This article mentions the following:

The thermogravimetric characteristics of glucose, L-lysine and their mixture were determined by thermogravimetry. The pyrolytic products of glucose and L-lysine mixture at 5 temperature ranges were analyzed by the combination of thermogravimetry, solid phase microextraction and gas chromatog.-mass spectrometry (TG-SPME-GC-MS). The effects of the proportion of glucose to L-lysine, and air flow on the yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine were investigated as well. The results showed that : (1) the activation energy of reaction of glucose/L-lysine model system was far lower than that of degradation on their own. There was an endothermic process at the early reaction stage. In the temperature range of 135 to 245°C weight loss started, the mixture lost about 40% of its weight (2) 39 Compounds were identified in pyrolytic products of the model system. Ketones and furfurals were the main products at 100 to 250°C. From 250 to 350°C, pyrazine, pyridine, pyrrole, oxazole, imidazole and other nitrogenous heterocyclic compounds were detected. And the important flavor compounds were produced started from 150°C. (3) The yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine culminated at air velocity of 200 mL/min and the mass ratio of glucose to L-lysine of 1:1. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Category: benzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Comprehensive characterization of mainstream marijuana and tobacco smoke was written by Graves, Brian M.;Johnson, Tyler J.;Nishida, Robert T.;Dias, Ryan P.;Savareear, Benjamin;Harynuk, James J.;Kazemimanesh, Mohsen;Olfert, Jason S.;Boies, Adam M.. And the article was included in Scientific Reports in 2020.Synthetic Route of C9H9NO This article mentions the following:

Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quant. similar in volatility, shape, d. and number concentration, albeit with differences in size, total mass and chem. composition Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4 times more total mass. New measurements of semivolatile fractions determined that >97% of the mass and volume of the particles from either smoke source are comprised of semivolatile compounds For tobacco smoke and marijuana smoke, resp., 4350 and 2575 different compounds are detected, of which 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause neg. health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their phys. and chem. properties. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Synthetic Route of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Some novel reactions of benzoxazole derivatives with dimethyl acetylenedicarboxylate. II was written by Kawahara, Norio;Katsuyama, Michiko;Itoh, Tsuneo;Ogura, Haruo. And the article was included in Heterocycles in 1981.Reference of 5676-58-4 This article mentions the following:

Reaction of 2-alkylbenzoxazoles I (R, R¹ = H, H; Me, H; Me, Me) with R²CCR² (R² = CO₂Me) in EtOH or CMe₃OH at room temperature gave tricyclic compound II, hydration product III (R³ = H), solvent adduct III (R³ = CMe₃), and ring-opened compounds RC₆H₃(O₂CCH₂R¹)NHCR²:CHR²-4,3 and RC₆H₃(OH)[N(COCH₂R¹)CR²:CHR²]-4,3 (IV). IV was a main product of photochem. reaction of I with R²CCR². In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives was written by Kumar, Vishal;Dhawan, Sanjeev;Bala, Renu;Girase, Pankaj Sanjay;Singh, Parvesh;Karpoormath, Rajshekhar. And the article was included in Tetrahedron in 2022.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

Simple yet novel oxidant, metal and solvent-free green protocol for synthesizing differently 2-substituted 1,3-benzoxazoles I [R¹ = Me, Ph, Bn, etc.; R² = H, 6-Me, 5-Cl, etc.; X = O] and benzothiazoles I [R¹ = Me; R² = H, 5-Cl; X = S] from 2-aminophenol hydrochloride salt, unactivated amide as in situ carbon source was reported. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy was applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Indium-mediated one-pot synthesis of benzoxazoles or oxazoles from 2-nitrophenols or 1-aryl-2-nitroethanones was written by Lee, Jung June;Kim, Jihye;Jun, Young Moo;Lee, Byung Min;Kim, Byeong Hyo. And the article was included in Tetrahedron in 2009.HPLC of Formula: 5676-58-4 This article mentions the following:

One-pot reduction-triggered heterocyclizations from 2-nitrophenols to benzoxazoles and from 1-aryl-2-nitroethanones to oxazoles were investigated. In the presence of indium/AcOH in benzene at reflux, 2-nitrophenols and R-C(OMe)₃ (R=H, Me, Ph) produced excellent yields of corresponding benzoxazoles within an hour. Similarly, 1-aryl-2-nitroethanones and Ph-C(OMe)₃ in the presence of indium/AcOH in acetonitrile transformed into the corresponding oxazoles with good yields. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Structure and reactivity of benzoxazoles: carbon-13 nuclear magnetic resonance study was written by Llinares, Jeanine;Galy, Jean Pierre;Faure, Robert;Vincent, Emile Jean;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1979.Formula: C9H9NO This article mentions the following:

Thirty-four benzoxazoles, oxazole, and 10 o-aminophenols were studied by ¹³C NMR spectroscopy. All the signals are attributed to substituent effects. The structures of the products obtained by the nitration of benzoxazole were determined by ¹³C NMR. The shifts induced by substitution at the 2 position are discussed as a function of an empirical model by using the structural parameters F, R, and Q^*. Azido-tetrazole equilibrium (N₃ in position 2) and prototropic tautomerism (NH₂, OH, and SH in position 2) are also discussed. The chem. shifts and coupling constants of oxazole and unsubstituted benzoxazole are compared. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Homo- and Heteroannulation of sp³ C-H Bonds in Acetophenones for Divergent Synthesis of Thienothiazoles was written by Pham, Phuc H.;Nguyen, Khang X.;Pham, Hoai T. B.;Nguyen, Tung T.;Phan, Nam T. S.. And the article was included in Organic Letters in 2019.Safety of 2,5-Dimethylbenzoxazole This article mentions the following:

A synthesis of fused thieno[3,2-d]thiazoles I (R = H, Me, OMe, etc.) via direct functionalization of C(sp³)-H bonds in acetophenones was reported. The transformation is divergent to afford either 2-phenylbenzo[4,5]thieno[3,2-d]thiazoles or benzo[4,5]thieno[3,2-d]thiazol-2-yl(phenyl)methanones. Cross-coupling of acetophenones with C-H bonds in phenylacetic acids, methylazaarenes, and aldehydes was also feasible. Excellent tolerance of functionalities was observed This method marks a rare functionalization of C(sp³)-H bonds in acetophenones to obtain heterocycles in the absence of pre-functionalized oxime esters. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Safety of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Safety of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of N-octadecylsquarylium dye was written by Tanaka, Motoo;Sekiguchi, Tatsuo;Kawabata, Yasujiro;Nakamura, Takayoshi;Manda, Eiichiro. And the article was included in Nippon Kagaku Kaishi in 1987.Recommanded Product: 5676-58-4 This article mentions the following:

The synthesis of N-octadecylsquarylium dyes I (R = H, Me, OMe, Cl; X = CMe₂, S, Se) and II (R¹ = Me, Et; R₂ = H, Me, OH) was studied. A mixture of 2 mol N-octadecylated intermediate and 1 mol squaric acid was refluxed 24 h in 2:3 (volume) PhCl-1-pentanol (Method A), or heated 5 h at 160° in the presence of Nafion H resin (Method B). Method B gave better yields than method A. The yields of I were affected by the electronegativity of X and were in the order CMe₂ > Se > S > O. In the case of II good yields were attained for R² which was an electron-releasing substituent such as OH or Me. IR and NMR measurements revealed that I and II had sym. 1,3-bonded squarylium rings, consistent with the results of N-Me squarylium dyes reported by A. Treibs and K. Jacob (1966,1698). In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem