Tag: 128156-54-7

Methyl benzo[d]oxazole-4-carboxylate, cas is 128156-54-7, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,128156-54-7

To a solution of 8-chloro-3-(1-methyl-1H-pyrazol-4-yl)isoquinoline (IntermediateD,310 mg,1.27mmol),methyl benzo[d]oxazole-4-carboxylate (150 mg,0.85 mmol)and K3P04(539 mg,2.54 mmol)in NMP (8 mL)were added bis(1-adamantyl)-butyl-phosphane (61 mg,10 0.17 mmol)palladium(II)acetate (19 mg,0.08 mmol). The reaction mixture was stirred at roomtemperature for 15 min and heated to 125 oc for 24 h under a nitrogen atmosphere. Aftercooling the reaction to room temperature,the mixture was filtered and concentrated in vacuo.The crude residue was purified by silica gel column chromatography (petroleum ether/EtOAc =3:1)to give the title compound (150 mg,46%)as a brown solid. LCMS M/Z (M+H)385.

With the rapid development of chemical substances, we look forward to future research findings about 128156-54-7

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; WAI, John; LAI, Kwong Wah; WANG, Fei; (251 pag.)WO2017/205536; (2017); A2;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belong benzoxazole compound,Methyl benzo[d]oxazole-4-carboxylate,128156-54-7,Molecular formula: C9H7NO3,mainly used in chemical industry, its synthesis route is as follows.,128156-54-7

General procedure: To a degassed solution (N2 was purged for 10 min) of methyl 1,3-benzoxazole-4-carboxylate (150 mg, 0.847mmol) and N-(2-iodophenyl)benzamide 2a (273 mg, 0.847 mmol) in anhydrous toluene (4ml) , CuI (32 mg, 0.169 mmol), xantphos (98 mg, 0.169 mmol), Pd(OAc)2 (10 mg, 0.042 mmol), Cs2CO3 (685 mg, 2.117 mmol) were added at room temperature under nitrogen atmosphere. Reaction mixture was continued for 20 hours at reflux condition. After the completetion of the reaction (monitored by TLC), Reaction mixture was filtered through celite bed and washed with methanol (10 ml),filtrate was concentrated. Crude mass which was purified by column chromatography over silica gel (230-400 mesh) using DCM-Methanol (1:9) as elutant to affordthe products 3a (284 mg) as white solid. All the other compounds 3b-3r were prepared similarly following the above procedure.

With the synthetic route has been constantly updated, we look forward to future research findings about Methyl benzo[d]oxazole-4-carboxylate,belong benzoxazole compound

Reference£º
Article; Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram; Tetrahedron Letters; vol. 56; 11; (2015); p. 1374 – 1377;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Methyl benzo[d]oxazole-4-carboxylate, cas is 128156-54-7, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,128156-54-7

General procedure: To a degassed solution (N2 was purged for 10 min) of methyl 1,3-benzoxazole-4-carboxylate (150 mg, 0.847mmol) and N-(2-iodophenyl)benzamide 2a (273 mg, 0.847 mmol) in anhydrous toluene (4ml) , CuI (32 mg, 0.169 mmol), xantphos (98 mg, 0.169 mmol), Pd(OAc)2 (10 mg, 0.042 mmol), Cs2CO3 (685 mg, 2.117 mmol) were added at room temperature under nitrogen atmosphere. Reaction mixture was continued for 20 hours at reflux condition. After the completetion of the reaction (monitored by TLC), Reaction mixture was filtered through celite bed and washed with methanol (10 ml),filtrate was concentrated. Crude mass which was purified by column chromatography over silica gel (230-400 mesh) using DCM-Methanol (1:9) as elutant to affordthe products 3a (284 mg) as white solid. All the other compounds 3b-3r were prepared similarly following the above procedure.

With the synthetic route has been constantly updated, we look forward to future research findings about Methyl benzo[d]oxazole-4-carboxylate,belong benzoxazole compound

Reference£º
Article; Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram; Tetrahedron Letters; vol. 56; 11; (2015); p. 1374 – 1377;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

128156-54-7, Methyl benzo[d]oxazole-4-carboxylate is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a degassed solution (N2 was purged for 10 min) of methyl 1,3-benzoxazole-4-carboxylate (150 mg, 0.847mmol) and N-(2-iodophenyl)benzamide 2a (273 mg, 0.847 mmol) in anhydrous toluene (4ml) , CuI (32 mg, 0.169 mmol), xantphos (98 mg, 0.169 mmol), Pd(OAc)2 (10 mg, 0.042 mmol), Cs2CO3 (685 mg, 2.117 mmol) were added at room temperature under nitrogen atmosphere. Reaction mixture was continued for 20 hours at reflux condition. After the completetion of the reaction (monitored by TLC), Reaction mixture was filtered through celite bed and washed with methanol (10 ml),filtrate was concentrated. Crude mass which was purified by column chromatography over silica gel (230-400 mesh) using DCM-Methanol (1:9) as elutant to affordthe products 3a (284 mg) as white solid. All the other compounds 3b-3r were prepared similarly following the above procedure.

The synthetic route of 128156-54-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram; Tetrahedron Letters; vol. 56; 11; (2015); p. 1374 – 1377;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem