Tag: 149.1467

Heteroleptic palladium(II) complexes containing N-heterocyclic carbenes and 4-phenyl-1H-1,2,3-triazole: Synthesis, characterization, and catalytic application was written by Chen, Wei;Yang, Jin. And the article was included in Journal of Coordination Chemistry in 2018.Electric Literature of C8H7NO2 This article mentions the following:

Reaction of the dimeric N-heterocyclic carbene (NHC) palladium compounds [Pd(μ-Cl)(Cl)(NHC)]₂ with 4-phenyl-1H-1,2,3-triazole gave four mono- and dinuclear complexes 1–4. Mononuclear complexes 1 and 2 [(NHC)PdCl₂(4-phenyl-1H-1,2,3-triazole)] were obtained when the reactions were performed in CH₂Cl₂, whereas dinuclear complexes 3 and 4 [Pd₂(μ-Cl)(μ-4-phenyl-1H-1,2,3-triazole)Cl₂(NHC)₂] were obtained when the reactions were performed in THF in reflux with Et₃N as the base. Further explorations of the catalytic properties of for Pd-catalyzed transformations were performed and these complexes exhibited moderate to high catalytic activities for Suzuki-Miyaura coupling and arylation of benzoxazoles with aryl bromides. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Electric Literature of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Electric Literature of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper and cobalt co-catalyzed aerobic oxidative cross-dehydrogenative coupling reaction of (benzo)azoles was written by Li, Yanrong;Qian, Fen;Ge, Xia;Liu, Tao;Jalani, Hitesh B.;Lu, Hongjian;Li, Guigen. And the article was included in Green Chemistry in 2019.Name: 5-Methoxybenzo[d]oxazole This article mentions the following:

The dehydrogenative cross-coupling (CDC) reaction of diversely substituted azoles, e.g., benzoxazole synergistically catalyzed by copper and cobalt, is reported. This protocol represents the first example of the use of air as an oxidant to carry out this chem. reaction. The process provides a convenient and economical method for the construction of valuable unsym. bis-heteroaryl compounds, e.g., 2-(benzo[d]thiazol-2-yl)benzo[d]oxazole including bis-benzoazole compounds that are not obtained in previous catalytic CDC reactions. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Name: 5-Methoxybenzo[d]oxazole).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 5-Methoxybenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nickel-catalyzed C-H arylation of benzoxazoles and oxazoles: Benchmarking the influence of electronic, steric and leaving group variations in phenolic electrophiles was written by Steinberg, Deborah F.;Turk, Morgan C.;Kalyani, Dipannita. And the article was included in Tetrahedron in 2017.Application of 132227-03-3 This article mentions the following:

Electronic, steric and leaving group effects for Ni-catalyzed direct arylations using C-O electrophiles were benchmarked. The scope of arylations with pivalates was general with respect to both the electronics on the electrophile and the azoles. Furthermore, the arylation of azoles with tosylates, mesylates and carbamates with varying electronics was explored, and showed electronic trends similar to those of the pivalate reactions. Finally, the relative rate of arylation of 5-Me benzoxazole with two electronically-similar electrophiles bearing different leaving groups was established. The results from these studies implicate the following order of relative reactivity: mesylates>pivalates>carbamates. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Application of 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Application of 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium-Catalyzed Direct Cyclopropylation of Heterocycles was written by Wu, Xiaojin;Lei, Chuanhu;Yue, Guizhou;Zhou, Jianrong. And the article was included in Angewandte Chemie, International Edition in 2015.Application of 132227-03-3 This article mentions the following:

Variously substituted 1,3-azoles (oxazole, benzoxazole, 4-methylthiazole, caffeine, etc.) and 2- and 3-cyanothiophenes were directly cyclopropylated with cyclopropyl iodides in the presence of a simple palladium catalyst. The relative configuration on the three-membered rings was retained in the products. In this process, the cyclopropyl-halide bond underwent concerted oxidative addition to palladium(0), and cyclopropyl radicals were not involved in the productive pathway. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Application of 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Application of 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

C-H Bond Functionalization of Benzoxazoles with Chromium(0) Fischer Carbene Complexes was written by Hu, Fangdong;Yang, Jinghui;Xia, Ying;Ma, Chen;Xia, Haiping;Zhang, Yan;Wang, Jianbo. And the article was included in Organometallics in 2016.Electric Literature of C8H7NO2 This article mentions the following:

An efficient C-H bond functionalization of benzoxazoles with chromium(0) Fischer carbene complexes under catalyst-free conditions has been developed. A series of benzoxazoles and chromium(0) carbene complexes are compatible with the reaction. This transformation provides an alternative way for C-H bond alkylation of benzoxazoles. In the reaction mechanism the elimination of the Cr(CO)₅ fragment seems more favored than the elimination of an alkoxy group, which is in sharp contrast to the previous reports on the reaction of organolithium reagents with chromium(0) Fischer carbene complexes. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Electric Literature of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Electric Literature of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium-catalyzed trisallylation of benzoxazoles and 2-aryl-1,3,4-oxadiazoles with alkyne was written by Zheng, Jun;Hosseini-Eshbala, Fereshteh;Dong, Ya-Xi;Breit, Bernhard. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 132227-03-3 This article mentions the following:

A Pd-catalyzed direct C-H trisallylation of azoles with alkyne has been described. A consecutive C(sp²)-H allylation/olefin isomerization/double C(sp³)-H allylation of azoles and alkyne via a palladium catalysis system proceeds efficiently to afford the corresponding C2-alkenylated azoles containing an all quaternary carbon center. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Recommanded Product: 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Abnormal-NHC-Supported Nickel Catalysts for Hydroheteroarylation of Vinylarenes was written by Vijaykumar, Gonela;Jose, Anex;Vardhanapu, Pavan K.;P, Sreejyothi;Mandal, Swadhin K.. And the article was included in Organometallics in 2017.Category: benzoxazole This article mentions the following:

Herein the authors report the hydroheteroarylation of vinylarenes with benzoxazole in the presence of a free abnormal N-heterocyclic carbene and Ni(COD)₂, resulting in 1,1-diarylethane products exclusively. In an attempt to understand the mechanism of this catalytic reaction, two abnormal-NHC (aNHC)-coordinated Ni(II) cyclooctenyl complexes were isolated and their solid-state structures were determined by x-ray crystallog. studies. These Ni(II) cyclooctenyl complexes act as active catalyst precursors to generate in situ aNHC-Ni(0) species, which undergo oxidative addition with heteroarene to form Ni(II) hydride intermediates. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Category: benzoxazole).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes as precatalysts for direct arylation of azoles with aryl bromides was written by Yang, Jin. And the article was included in Tetrahedron in 2019.Computed Properties of C8H7NO2 This article mentions the following:

A series of mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes with general formula [(NHC)Pd(η³-allyl)]₂(μ₂-N-heterocycles)(BF₄)₂ were prepared in one pot based on anion metathesis of (NHC)Pd(η³-allyl)Cl complexes and then ligand replacement with N-heterocycles [N-heterocycles = pyrazine (pyz), 4,4′-bipyridine (bpy) and trans-4,4′-bipyridylethylene (bpe)]. The solid-state structures showed dinuclear structures with two palladium(II) centers holding together by bridged N-heterocycles. Initially investigation of the obtained complexes as precatalysts for direct C-H bond arylation of azoles with aryl bromides was carried out. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Computed Properties of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Computed Properties of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

TEMPO/PhI(OAc)₂-mediated Direct Sulfoximination of Benzoxazoles under Metal-free Conditions was written by Wang, Jian;Tu, Changqing;Feng, Mei-Lin;Li, Nan. And the article was included in Chemistry Letters in 2022.HPLC of Formula: 132227-03-3 This article mentions the following:

A metal-free reaction system consisting of TEMPO and PhI(OAc)₂ for the oxidative C-N coupling of benzoxazoles with NH-sulfoximines had been developed to obtain arylsulfoximines I [R¹ = H, 5-Cl, 7-Br, etc.; R² = Me, Et, n-Bu, Bn; R³ = Ph, 4-FC₆H₄, 2-BrC₆H₄, etc.]. The reaction could proceed under ambient atm. without any metal catalyst at room temperature to afford the corresponding 2-iminoazoles in moderate to high yields. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3HPLC of Formula: 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.HPLC of Formula: 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem