Tag: 165.2123

Synthesis of 2-(benzylthio)benzimidazole, 2-[(benzimidazol-2-yl)methylthio]benzimidazole and structural analogues against Haemonchus contortus was written by Akpa, Sagne Jacques;Say, Martial Venance;Zoakouma, Roger Simplice Pepin;Fante, Bamba;Sissouma, Drissa;Adjou, Ane. And the article was included in African Journal of Pharmacy and Pharmacology in 2016.Synthetic Route of C8H7NOS This article mentions the following:

The coupling of 2-mercaptobenzimidazoles with (chloromethyl)benzene derivatives gave 2-(benzylthio)benzimidazoles I (R¹ = H, NO₂, C₆H₅CO; R² = H, 4-Cl, 3-NO₂, 2,4-Cl) on one hand, and coupling with the 2-(chloromethyl)benzimidazoles on the other gave 2-[(benzimidazolyl)methylthio]benzimidazoles and analogs II (R⁴ = H, 6-CH₃, 5-NO₂, etc.; R³ = H, NO₂, C₆H₅CO; X = NH, S, O). The evaluation of the anthelmintic activities of these mols. on Haemonchus contortus showed that the introduction of the nitro group (NO₂) in the structure causes a significant increase of the activity. Among the mols. evaluated in vitro for their anti-infectious activity, compounds I (R¹ = H; R² = 3-NO₂) and II (R¹ = 5-NO₂, 5-C₆H₅CO; R² = H, NO₂, C₆H₄CO) revealed an activity which is comparable to that of the reference mols. (ivermectin and fenbendazole). In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Synthetic Route of C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Synthetic Route of C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Regioselective Thiolation of Arenes and Heteroarenes: C-H Functionalization Strategy for C-S Bond Formation was written by Varun, Begur Vasanthkumar;Prabhu, Kandikere Ramaiah. And the article was included in Journal of Organic Chemistry in 2014.Formula: C8H7NOS This article mentions the following:

A facile transition-metal-free oxidative cross-dehydrogenative coupling reaction involving selective formation of a C-S bond leading to the synthesis of arylthiobenzoxazoles, heteroarylthiobenzoxazoles, and arylthiobenzothiazoles has been described. This highly regioselective C-H functionalization reaction with electron-rich aromatic systems including heteroaromatics is achieved by reversing the reactivity of sulfur in the presence of a suitable oxidant and strong acid. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Formula: C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Formula: C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols was written by Deligeorgiev, Todor G.;Kaloyanova, Stefka S.;Lesev, Nedyalko Y.;Vaquero, Juan J.. And the article was included in Monatshefte fuer Chemie in 2011.Recommanded Product: 6-Methyl-1,3-benzoxazole-2-thiol This article mentions the following:

An improved environmentally benign procedure for the synthesis of substituted 2-thiobenzothiaoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols, e.g., I, by cyclization of 2-aminophenols, 2-aminothiophenols, 1,2-phenylenediamines, or 2-amino-3-hydroxypyridines with potassium O-ethyldithiocarbonate in PEG 400 or glycerol under directed microwave irradiation is described. The method can be applied to the synthesis of a variety of derivatives In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Recommanded Product: 6-Methyl-1,3-benzoxazole-2-thiol).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 6-Methyl-1,3-benzoxazole-2-thiol

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A new 5-HT₃ receptor ligand. II. Structure-activity analysis of 5-HT₃ receptor agonist action in the gut was written by Yamada, Megumi;Sato, Yasuo;Kobayashi, Kazuko;Konno, Fukio;Soneda, Tomoko;Watanabe, Takashi. And the article was included in Chemical & Pharmaceutical Bulletin in 1998.Category: benzoxazole This article mentions the following:

Several modified 2-piperazinyl benzoxazole derivatives, which exhibit an agonistic effect on gastrointestinal motility, were synthesized and their effects on the contraction of guinea-pig ileum were examined The quaternary piperazinyl benzoxazole structure has a restricted conformation and stereostructure compared to those of the other 5-HT₃ receptor agonists, serotonin and meta-chlorophenylbiguanide. The mutual positions of the aromatic ring, N atom and terminal amine are considered to form the pharmacophore of the 5-HT₃ receptor agonist in the gut. In the serotonin-evoked reflex bradycardia [Bezold-Jarisch (B-J) reflex] inhibition test using rats the B-J reflex-inducing ratio was different for each synthesized compound Probably in these 5-HT₃ receptor agonists, the substituents of the benzoxazole ring influence the B-J reflex-inducing activity in rats. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Category: benzoxazole).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem