Tag: 200-300

Facile synthesis of arylboronic esters by palladacycle-catalyzed bromination of 2-arylbenzoxazoles and subsequent borylation of the brominated products was written by Leng, Yuting;Yang, Fan;Zhu, Weiguo;Zou, Dapeng;Wu, Yangjie;Cai, Ranran. And the article was included in Tetrahedron in 2011.SDS of cas: 99586-31-9 This article mentions the following:

An efficient and facile synthesis of arylbenzoxazolyl pinacolboronates has been described using cyclopalladated ferrocenylimines as the catalysts. This reaction includes two steps (bromination of 2-arylbenzoxazoles and borylation of the arylbromobenzoxazoles) in succession. The regioselective bromination of benzoxazoles occurred by electrophilic substitution using NBS as the brominating reagent; the site of bromination was determined by HMBC (¹H-detected heteronuclear multiple bond correlation) spectra of the products. The subsequent borylation could be carried out only after removal of the solvent and addition of a second catalyst to afford the arylboronic esters in moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-catalyzed an efficient synthesis, characterization of 2-substituted benzoxazoles, 2-substituted benzothiazoles derivatives and their anti-fungal activity was written by Sirgamalla, Rambabu;Kommakula, Ashok;Konduru, Sumalatha;Ponakanti, Ravindar;Devaram, J.;Boda, Sakram. And the article was included in Chemical Data Collections in 2020.Formula: C13H8BrNO This article mentions the following:

An efficient synthesis of 2-substituted benzoxazoles, (I) (R = H, Me, Cl, NO₂; R1 = 3-F, 2-OH, 4-Me, 4-OMe, etc.) and 2-substituted benzothiazole (I) (R = H, Me, Cl, NO₂; R1 = 4-F, 4-Me, 4-OMe, 4-NO₂, etc.) from condensation of 2-aminophenol, and 2-aminothiophenol react with various aldehydes in Cu₂O in the presence of DMSO oxidant system has been developed. This reaction is operationally simple, proceeds with copper catalysts, tolerates a wide range of functionalities, and provides elemental anal. (C, H, N) providing desired products in good to excellent yields. All the synthesized compounds were screened for anti-fungal activity. Among all the compounds shows good activity I (R = H, R₁= 4-OMe; R = Me, R₁= 4-OMe; R = Cl, R₁= 4-OMe; R = Cl, R₁= 4-OH), (III) and (II) (R = H, R₁= 4-F; R = H, R₁= 4-OMe) shows equal to reference drug. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

New Approach for Controllable Synthesis of N-MnO_x Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis was written by Tang, Jun;Cao, Yali;Ruan, Fei;Li, Fengfeng;Jin, Yangxin;Ha, Minh Ngoc;Han, Xinya;Ke, Qingping. And the article was included in Industrial & Engineering Chemistry Research in 2020.Related Products of 99586-31-9 This article mentions the following:

Herein, the novel approach for controlled synthesis of nitrogen doped MnO_x (denoted as N-MnO₂, N-Mn₅O₈ and N-Mn₃O₄) by adjusting the heteroatom nitrogen amount is reported. It was shown that N-MnO₂ catalyst is a sustainable and cost-effective heterogeneous catalyst for condensation of 2-aminophenols and o-phenylenediamine with alcs. to afford the corresponding benzoxazoles and benzimidazole, resp. The N-MnO₂ catalyst displayed >99.9% yield for benzoxazole synthesis under room temperature and no decay (10 cycles), compared with the negligible activity (∼0%) for MnO₂ catalysts. X-ray absorption spectroscopies and exptl. studies uncovered that oxygen vacancies, generated by heteroatom N doping, act as the key role for promoting intramol. oxidative dehydrogenation of alc. and 2-aminophenol derivatives to directly yield desired products. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Related Products of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Related Products of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1-(Hydroxymethyl)-1H-benzotriazole: An Efficient Ligand for Copper-Catalyzed Ullmann-Type Coupling Reaction Leading to Expeditious Synthesis of Diverse Benzoxazoles and Benzothiazoles was written by Singh, Mala;Bose, Priyanka;Singh, Anoop S.;Tiwari, Vinod K.. And the article was included in ChemistrySelect in 2019.Electric Literature of C13H8BrNO This article mentions the following:

Cu-Catalyzed Ullmann coupling of aryl bromides and amides/thioamides was performed for the facile synthesis of diverse benzoxazoles and benzothiazoles I [R = H, 2-Me, 4-Br, etc.; R¹ = H, Cl; R² = H, Br; X = O, S] in the presence of 1-(hydroxymethyl)-1H-benzotriazole as ligand and K₂CO₃ as base in anhydrous DMF at 120 °C. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis and characterization of amino glucose-functionalized silica-coated NiFe₂O₄ nanoparticles: A heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of 2,4,5-trisubstituted imidazoles, benzo[d]imidazoles, benzo[d] oxazoles and azo-linked benzo[d]oxazoles was written by Fekri, Leila Zare;Nikpassand, Mohammad;Shariati, Shahab;Aghazadeh, Behnaz;Zarkeshvari, Reza;Norouz pour, Nahid. And the article was included in Journal of Organometallic Chemistry in 2018.Synthetic Route of C13H8BrNO This article mentions the following:

Amino glucose-functionalized silica-coated NiFe₂O₄ nanoparticles (NiFe₂O₄@SiO₂@amino glucose) were chem. synthesized and characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), thermal gravimetric anal. (TGA), energy dispersive X-ray anal. (EDX), vibrating sample magnetometer (VSM), Zetasizer and Fourier transform IR spectroscopy (FT-IR) instruments. NiFe₂O₄@SiO2@amino glucose supply an environmentally friendly procedure for the synthesis of 2,4,5-trisubstituted imidazoles through one-pot multicomponent condensation of benzil or benzoin, ammonium acetate with aryl aldehydes and for the synthesis of benzoxazoles using condensation reaction of 2-aminophenol with aryl aldehydes under solvent free condition. In the other study, this synthesized magnetically reusable catalyst was introduced as a new avenue for the synthesis of benzo[d]imidazoles using the reaction between aryl aldehydes and 1,2-diaminobenzene. These compounds were obtained in high yields and short reaction times. The catalyst could be easily recovered and reused for five cycles with almost consistent activity. Synthesized compounds were characterized by their phys. constant, comparison with authentic samples, FT-IR, ₁H NMR, ₁₃C NMR spectroscopy and elemental anal. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A TEMPO-Functionalized Ordered Mesoporous Polymer as a Highly Active and Reusable Organocatalyst was written by Guo, Ying;Wang, Wei David;Li, Shengyu;Zhu, Yin;Wang, Xiaoyu;Liu, Xiao;Zhang, Yuan. And the article was included in Chemistry – An Asian Journal in 2021.Reference of 99586-31-9 This article mentions the following:

The properties of high stability, periodic porosity, and tunable nature of ordered mesoporous polymers make these materials ideal catalytic nanoreactors. However, their application in organocatalysis has been rarely explored. We report herein for the first time the incorporation of a versatile organocatalyst, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), into the pores of an FDU-type mesoporous polymer via a pore surface engineering strategy. The resulting FDU-15-TEMPO possesses a highly ordered mesoporous organic framework and enhanced stability, and shows excellent catalytic activity in the selective oxidation of alcs. and aerobic oxidative synthesis of 2-substituted benzoxazoles, benzimidazoles and benzothiazoles. Moreover, the catalyst can be easily recovered and reused for up to 7 consecutive cycles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Reference of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nano ceria catalyzed synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media was written by Shelkar, Radheshyam;Sarode, Sachin;Nagarkar, Jayashree. And the article was included in Tetrahedron Letters in 2013.Electric Literature of C13H8BrNO This article mentions the following:

A series of substituted benzimidazoles, benzothiazoles, and benzoxazoles was synthesized by combining 1,2-phenylenediamine, 2-aminothiophenol, or 2-aminophenol with aryl, heteroaryl, aliphatic, α,β-unsaturated aldehydes in the presence of nano ceria (CeO₂) as an efficient heterogeneous catalyst. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A Mild, Efficient and Reusable Solid Phosphotungstic Acid Catalyst Mediated Synthesis of Benzoxazole Derivatives: A Grinding Approach was written by Patil, Mahadeo R.;Yelamaggad, Aditya;Keri, Rangappa S.. And the article was included in Letters in Organic Chemistry in 2016.Application of 99586-31-9 This article mentions the following:

Herein, PTA catalyzed synthesis of 2-arylbenzoxazoles from 2-aminophenols and different aromatic aldehydes using a grinding strategy in excellent yield is reported. The use of this reusable catalyst under solvent-free conditions has made this protocol practical, environmentally friendly and economically attractive. The simple work-up procedure, the short reaction times, the mild reaction conditions, the high yields of products and the non-toxicity of the catalyst are other advantages of the present method. This protocol approaches combines the advantages of both focused library synthesis and diversity oriented synthesis because of the simplification of reaction protocol. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mesoporous Poly(melamine-formaldehyde): A Green and Recyclable Heterogeneous Organocatalyst for the Synthesis of Benzoxazoles and Benzothiazoles Using Dioxygen as Oxidant was written by Yang, Daoshan;Liu, Peng;Zhang, Ning;Wei, Wei;Yue, Mingbo;You, Jinmao;Wang, Hua. And the article was included in ChemCatChem in 2014.SDS of cas: 99586-31-9 This article mentions the following:

A simple, highly efficient, and sustainable strategy for the synthesis of benzoxazole and benzothiazole derivatives was developed by using inexpensive, green, readily available, and recyclable mesoporous poly(melamine-formaldehyde) as a green, heterogeneous organocatalyst. The corresponding substituted benzoxazoles and benzothiazoles were obtained in good to excellent yields by aerobic oxidation of o-substituted aminobenzenes with various aldehydes under dioxygen atm. The catalyst can be completely recovered through simple filtration to be reused more than six times without significant loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-Catalyzed Direct C-H Bond Arylation of Benzoxazoles with Anilines was written by Feng, Pengju;Ma, Guojian;Zhang, Tianyu;Wang, Changwei. And the article was included in Asian Journal of Organic Chemistry in 2018.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

An efficient and easily managed protocol was developed for the synthesis of 2-aryl-benzoxazoles/benzothiazoles I [R = H, 5-Me, 5-Cl, 5-Br, 5-CO₂Et; R¹ = 2-Me, 4-Cl, 3-Br, etc.; X = O, S; Y = CH, N] by using a copper-catalyzed C-H arylation reaction between benzoxazole derivatives and in situ generated aryl diazonium salts. Under the optimized conditions a wide variety of products I were selectively obtained in moderate to good yields. Diphenylamine and 2,3′-bipyridine were also obtained under the same reaction conditions by employing aniline and pyridin-3-amine resp., as the sole starting material. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem