Tag: 200-300

DMF-Assisted Radical Cyclization of o-Isocyanodiaryl Ethers via 1,5-Aryl Migration: Construction of 2-Arylbenzoxazoles was written by Yuan, Sitian;Ye, Xiaoling;Cai, Jingyu;Song, Zhibin;Tan, Yuxing;Peng, Yiyuan;Ding, Qiuping. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: 99586-31-9 This article mentions the following:

A novel DMF-assisted radical cyclization of o-isocyanodiaryl ethers 2-CN-3-R¹-4-R² -5-R³ C₆HOR (R = 2-tert-butylphenyl, 2-phenylphenyl, pyridin-2-yl; R¹ = H, Me, Cl; R² = H, Me, Cl; R³ = H, Me) via 1,5-aryl migration has been developed for the synthesis of a series of 2-arylbenzoxazoles I and 2-phenyloxazolo[4,5-b]pyridine by the FeCl₃/TBHP/Et₃N catalytic system in DMF. However, N,N-dimethylbenzo[d]thiazole-2-carboxamide and N,N-dimethylbenzo[d]selenazole-2-carboxamide were obtained from the corresponding substrate 2-isocyanophenyl p-methoxyphenyl thioether and 2-isocyanodiphenyl selenoether under the same conditions. A possible mechanism may involve aryl 1,5-migration and DMF-assisted radical cyclization of o-isocyanodiaryl ethers I. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Recommanded Product: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of benzoxazoles by an efficient Ullmann-type intramolecular C_(aryl)-O bond-forming coupling cyclization with a BINAM-copper(II) catalyst was written by Naidu, Ajay B.;Sekar, Govindasamy. And the article was included in Synthesis in 2010.Formula: C13H8BrNO This article mentions the following:

A wide range of 2-arylbenzoxazoles were synthesized from the corresponding N-(2-iodophenyl)benzamides through intramol. C_(aryl)-O bond formation via Ullmann-type coupling cyclization in the presence of a catalytic amount of an easily available BINAM-copper(II) complex under very mild reaction conditions (82 °C). Less reactive bromo and chloro analogs of the N-(2-halophenyl)benzamides were also successfully cyclized to produce benzoxazoles, without increasing the catalyst loading. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

TiO₂-ZrO₂ composite: Synthesis, characterization and application as a facile, expeditious and recyclable catalyst for the synthesis of 2-aryl substituted benzoxazole derivatives was written by Patil, Mahadeo R.;Bhanushali, Jayesh T.;Nagaraja, Bhari Mallanna;Keri, Rangappa S.. And the article was included in Comptes Rendus Chimie in 2018.HPLC of Formula: 99586-31-9 This article mentions the following:

The activity of an efficient mesoporous TiO₂-ZrO₂ composite catalyst for the synthesis of 2-aryl substituted benzoxazole derivatives using 2-aminophenol and substituted benzaldehydes/heterocyclic aldehydes at moderate temperature was studied. The catalyst was prepared by a co-precipitation method and characterized by X-ray diffraction, BET surface area and SEM. The effect of temperature, solvents and catalyst concentration on the synthesis of benzoxazole derivatives was systematically investigated. Short reaction times, green-reaction profiles, good to excellent yields, reliable cost efficiency, simple workup conditions and reusability of an eco-friendly catalyst were the noteworthy highlights of the reported method. The catalyst could be easily recovered and reused several times without any significant loss in the yield. The use of the present catalytic system to mediate the title chem. synthesis in a synthetic operation was important for the development of new atom-economic strategies and this was efficient in building complex structures from simple starting materials in an environmentally benign fashion. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9HPLC of Formula: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.HPLC of Formula: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles was written by Saha, Prasenjit;Ali, Ashif Md.;Ghosh, Pokhraj;Punniyamurthy, Tharmalingam. And the article was included in Organic & Biomolecular Chemistry in 2010.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

Cobalt(II)-complex catalyzes efficiently the intramol. C-N and C-O cross-couplings of Z-N’-(2-halophenyl)-N-phenylamidines, e.g. I, and N-(2-bromophenyl)benzamides, e.g. II, to afford the corresponding substituted benzimidazoles and benzoxazoles, e.g. III [X = NPh, O], in the presence of K₂CO₃ at moderate temperature The protocol is general, air stable and affords the products selectively in moderate to high yield. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-Mediated Synthesis of Substituted 2-Aryl-N-benzylbenzimidazoles and 2-Arylbenzoxazoles via C-H Functionalization/C-N/C-O Bond Formation was written by Guru, Murali Mohan;Ali, Ashif Md.;Punniyamurthy, Tharmalingam. And the article was included in Journal of Organic Chemistry in 2011.Recommanded Product: 99586-31-9 This article mentions the following:

An efficient method for the transformation of N-benzyl bisarylhydrazones, e.g., I, and bisaryloxime ethers, e.g., II, to functionalized 2-aryl-N-benzylbenzimidazoles, e.g., III, and 2-arylbenzoxazoles, e.g., IV, is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or electron-withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Recommanded Product: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Deep eutectic solvent-catalyzed arylation of benzoxazoles with aromatic aldehydes was written by Tran, Phuong Hoang;Thi Hang, Anh-Hung. And the article was included in RSC Advances in 2018.SDS of cas: 99586-31-9 This article mentions the following:

A novel and efficient methodol. for the arylation of benzoxazoles with aromatic aldehydes catalyzed by deep eutectic solvent has been developed. The reaction smoothly proceeded with a wide range of substrates to give the desired products in high yields within short reaction time. Deep eutectic solvents are easily recovered and reused without significant loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of Benzazoles through Electrochemical Oxidative Cyclization Reactions was written by An, Qi;He, Chaoyin;Fan, Xiaodong;Hou, Chuanfu;Zhao, Jian;Liu, Yue;Liu, Hao;Ma, Junjie;Sun, Zhizhong;Chu, Wenyi. And the article was included in ChemElectroChem in 2020.Synthetic Route of C13H8BrNO This article mentions the following:

An effective method for the synthesis of benzazoles through the electrochem. oxidative cyclization of o-aminophenol/o-aminothiophenol/o-phenylenediamine and aldehydes was developed. A series of benzazoles were efficiently synthesized by using this method in good yields. Furthermore, this method was applied to the synthesis of the drug thiabendazole in a gram-scale reaction, which proved the practicality of the method. This approach avoids using catalysts and oxidants and has the advantages of wide substrate range, mild reaction conditions and good tolerance of functional groups. Finally, the possible reaction mechanism was proposed and supported by cyclic voltammetry (CV) and control experiments In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction was written by Zhang, Yong;Ji, Min. And the article was included in European Journal of Organic Chemistry in 2019.Recommanded Product: 99586-31-9 This article mentions the following:

A mol. I₂-promoted one-pot synthesis of 2-aryl benzoxazoles was developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chems. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction and provided a potential route for introducing certain groups at any site of the scaffold. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Modified palladium-catalyzed regioselective ortho-arylation of sp² C-H bond substrates with a low catalyst loading was written by Yang, Fan;Wu, Yangjie;Li, Yanan;Wang, Biao;Zhang, Junli. And the article was included in Tetrahedron in 2009.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A novel and generally applicable system for ortho-arylation of a broad range of sp² C-H bond substrates such as arylated benzoxazoles, acylated anilines, and pyridines has been developed. The arylation was performed in trifluoroacetic acid (TFA) under air by using PdCl₂ as the catalyst with a low catalyst loading of 1 mol %. And it was found for the first time that the addition of weak base K₃PO₄ to the acidic solvent could remarkably enhance the reaction rate. The arylated products were isolated in moderate to good yields with high regioselectivity for the substrates containing a meta-substituent. This arylation is tolerant with various functional groups such as CH₃, CH₃O, CH₃CO, Br, and Cl. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In-vitro anti-cancer assay and apoptotic cell pathway of newly synthesized benzoxazole-N-heterocyclic hybrids as potent tyrosine kinase inhibitors was written by Desai, Sulaksha;Desai, Vidya;Shingade, Sunil. And the article was included in Bioorganic Chemistry in 2020.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A series of benzoxazole-N-heterocyclic hybrids I [R¹ = H, Br; Ar = 4-BrC₆H₄, 4-O₂NC₆H₄, quinoxalin-2-yl, etc.] was synthesized by a one-pot strategy. The mol. docking studies showed that compounds I to be inhibitors of tyrosine kinase enzyme which triggered growth of cancer cells. The cytotoxicity study of compounds I [R¹ = H, Ar = quinoxalin-2-yl, 2-chloro-3-quinolyl; R¹ = Br, Ar = 4-BrC₆H₄, 4-O₂NC₆H₄, quinoxalin-2-yl, 2-chloro-3-quinolyl] showed better potency against breast cancer cell lines MCF-7 and MDA-MB-231 in contrast to oral and lung cancer cell lines KB and A549. The tyrosine kinase activity was measured using universal tyrosine kinase assay kit using horseradish peroxide (HRP)-conjugated anti-phosphotyrosine kinase solution as a substrate. The compound I [R¹ = Br, Ar = quinoxalin-2-yl] exhibited maximum inhibition in activity of enzyme tyrosine kinase with IC₅₀ value 0.10 ± 0.16μM, than other compounds I which were studied and thus proved to be inhibitors of enzyme tyrosine kinase. The selective index of compounds I [R¹ = H, Ar = quinoxalin-2-yl, 2-chloro-3-quinolyl; R¹ = Br, Ar = 4-BrC₆H₄, 4-O₂NC₆H₄, quinoxalin-2-yl, 2-chloro-3-quinolyl] indicated non-toxic behavior, i.e. good anti-cancer activity. Further, fluorescence microscopic study helped to characterize the mode of cell death, which was found to be late apoptosis as indicated by orange fluorescence. The SAR anal. was also carried out. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem