Tag: 200-300

Synthesis of Benz-Fused Azoles via C-Heteroatom Coupling Reactions Catalyzed by Cu(I) in the Presence of Glycosyltriazole Ligands was written by Mishra, Nidhi;Singh, Anoop S.;Agrahari, Anand K.;Singh, Sumit K.;Singh, Mala;Tiwari, Vinod K.. And the article was included in ACS Combinatorial Science in 2019.Electric Literature of C13H8BrNO This article mentions the following:

D-Glucose-derived triazoles such as I were prepared for use as ligands in coupling and tandem coupling and cyclization reactions using CuI as catalyst and K₂CO₃ in DMF to yield benzoxazoles, benzothiazoles, benzimidazoles, arylaminobenzothiazoles, and benzimidazoquinazolinones. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Direct ortho-arylation of 2-arylbenzoxazoles via C-H activation was written by Yang, Fan;Wu, Yangjie;Zhu, Zhiwu;Zhang, Junli;Li, Yanan. And the article was included in Tetrahedron in 2008.Synthetic Route of C13H8BrNO This article mentions the following:

A new and highly regioselective arylation of 2-arylbenzoxazoles based on C-H activation has been developed. The results represent the first examples of palladium-catalyzed direct ortho-arylation of 2-arylbenzoxazoles and also provide a facile route for the synthesis of complicated structures containing arylated benzoxazoles moieties. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Facile Preparation of Benzoxazoles from S₈-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride was written by Gan, Haifeng. And the article was included in ChemistrySelect in 2019.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH₃, etc.; R¹ = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO₂-R² -C₆H₃OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R¹CH₂Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis through microwave irradiation, characterization and evaluation of antimicrobial activity of 2-phenyl-1,3-benzoxazole derivatives was written by Tariq, Sana;Wakode, Sharad. And the article was included in International Research Journal of Pharmacy in 2012.HPLC of Formula: 99586-31-9 This article mentions the following:

2-Phenyl-1,3-benzoxazoles were synthesized by the reaction of 2-aminophenol and acyl chlorides using microwave irradiation The compounds were evaluated for in-vitro antimicrobial activity against Bacillus pumilus, Bacillus subtilis (Gram pos.); Escherichia coli, Pseudomonas aeruginosa (Gram neg.); and Candida albicans and Aspergillus niger by agar-well diffusion at 2.5, 5, and 10 mg/mL. 2-(2-Methoxyphenyl)-, 2-(4-bromophenyl)-, 2-(3-chlorophenyl)-, and 2-(2-nitrophenyl)-1,3-benzoxazole exhibited good antibacterial activity. 2-Phenyl- and 2-(4-bromophenyl)-1,3-benzoxazole were potent antifungal compounds amongst the series. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9HPLC of Formula: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.HPLC of Formula: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chlorination and ortho-acetoxylation of 2-arylbenzoxazoles was written by Leng, Yuting;Yang, Fan;Zhu, Weiguo;Wu, Yangjie;Li, Xiang. And the article was included in Organic & Biomolecular Chemistry in 2011.Product Details of 99586-31-9 This article mentions the following:

Efficient and facile catalytic protocols for chlorination and ligand-directed ortho-acetoxylation of 2-arylbenzoxazoles have been developed. The chlorination is not a ligand-directed ortho-functionalization, but an electrophilic substitution process in the benzo ring of the benzoxazole moiety. Meanwhile, the acetoxylation exhibited high regioselectivity for the substrates containing a meta-substituent and occurred at the less sterically hindered ortho-C-H bond of the directing group. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Product Details of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Product Details of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A rapid and efficient microwave-assisted synthesis of 2-arylbenzoxazoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBH) under solvent-free condition was written by Shinde, Kailas W.;Keche, Ashish P.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A simple, rapid and efficient procedure for the synthesis of 2-arylbenzoxazole derivatives I [R= H, Me, MeO, Cl; R¹ = 3-Me, 3-MeO, 3-NO₂-4-Cl, etc.] was developed from 2-aminophenol and arylaldehydes by using 1,3-dibromo-5,5-dimethylhydantoin (DBH) in moderate to good yields under solvent-free microwave irradiation The remarkable efficiency of DBH under solvent free microwave irradiation led many advantages like, the use of non-corrosive, inexpensive reagents, simple workup procedure, in addition to the eco-friendly green chem. economical and environmental impacts. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

One-pot copper-catalyzed aerobic decarboxylative coupling of phenylacetic acids with o-aminobenzenes and dioxygen as the oxidant leading to benzoxazoles and benzothiazoles was written by Yang, Daoshan;Yan, Kelu;Wei, Wei;Tian, Laijin;Shuai, Yuanyuan;Li, Ruixia;You, Jinmao;Wang, Hua. And the article was included in Asian Journal of Organic Chemistry in 2014.Electric Literature of C13H8BrNO This article mentions the following:

A simple and practical copper-catalyzed one-pot method for the synthesis of benzoxazole and benzothiazole derivatives I (X = O, S; R¹ = H, 5-CH₃, 6-Cl, 6-Br; R² = H, 4-CH₃, 4-Cl, 4-Br, 4-F, 3-Br, 3-CH₃) from substituted phenylacetic acids and o-aminobenzenes as the starting materials, and dioxygen as the sole oxidant using inexpensive CuSO₄ as the catalyst obtained in moderate to good yields, is reported. The procedure was based on sequential copper-catalyzed decarboxylation and aerobic cyclization reactions. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Electric Literature of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Electric Literature of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem