Tag: 2382-96-9

As a common heterocyclic compound, it belong benzoxazole compound,Benzo[d]oxazole-2-thiol,2382-96-9,Molecular formula: C7H5NOS,mainly used in chemical industry, its synthesis route is as follows.,2382-96-9

General procedure: To a stirred suspension of Fe3O4(at)Tryptophan-La in H2O2(0.5 mL) at room temperature, sulfide or thiol (1.0 mmol) was added under solvent-free condition. After the completion of reaction (monitored by TLC), the catalyst was separated using a magnet and the reaction mixture was concentrated to get pure sulfoxide or disulfide derivatives.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo[d]oxazole-2-thiol,belong benzoxazole compound

Reference£º
Article; Tamoradi, Taiebeh; Irandoust, Asrin; Ghadermazi, Mohammad; Journal of the Iranian Chemical Society; vol. 16; 8; (2019); p. 1723 – 1733;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2382-96-9,Benzo[d]oxazole-2-thiol,as a common compound, the synthetic route is as follows.

General procedure: Potassium hydroxide (46 mmol), ethanol (25 mL) and water (10 mL) were added to a dried round-bottomed flask sequentially, followed by the dropwise addition of CS2 (25 mmol), after 15 min, (un)substituted 2-aminophenol (23 mmol) was added, then the resulting solution was heated to reflux for 4 h. The reaction solution was acidified to pH~4 with dilute hydrochloric acid and then poured into water, extracted with ethyl acetate, the organic phase was washed with brine, dried over anhydrous magnesium sulfate, concentrated under reduced pressure and the residue was purified via silica gel column chromatography to obtain the intermediate the (un)substituted 2-mercaptobenzoxazole as a yellow solid. Then, the (un)substituted 2-mercaptobenzoxazole (5.5 mmol) was refluxed in SOCl2 (15 mL) for 2 h, excessive SOCl2 was removed under reduced pressure to give (un)substituted 2-chlorobenzoxazole as a yellow solid which was used in next reaction without further purification. Finally, 60 % of NaH (1.0 mmol) was added into a solution of 3,3-dichloroallyloxyphe-noxy intermediates (1.0 mmol) in THF (5 mL), after 2 h, (un)substituted 2-chloro-benzoxazole (1.0 mmol) was added, the reaction mixture was stirred for another 5 h at room temperature. The reaction mixture was poured into water and extracted with ethyl acetate, the organic phase was washed with saturated sodium bicarbonate, brine, dried over anhydrous magnesium sulfate, concentrated and the residue was purified via silica gel column chromatography to afford the title compounds.

As the paragraph descriping shows that 2382-96-9 is playing an increasingly important role.

Reference£º
Article; Guan, Aiying; Qin, Yukun; Wang, Junfeng; Li, Bin; Journal of Fluorine Chemistry; vol. 156; (2013); p. 120 – 123;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem