Tag: M.W:100-200

Chemistry is an experimental science, Computed Properties of C7H7FN2O3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1075705-01-9, Name is 4-Fluoro-2-methoxy-5-nitroaniline, molecular formula is C7H7FN2O3, belongs to benzoxazole compound. In a document, author is Chernyshev, Anatoly V..

Polychromogenic molecular systems based on photo- and ionochromic spiropyrans

The obtained spiroindolinebenzopyrans bearing benzoxazole fragment in the position 8 of the benzopyran part appear as polychromogenic molecular systems exhibiting not only photochromic but also ionochromic properties. Photochromic properties demonstrate variability of spectral kinetic characteristics in the wide range depending on structural features and a solvent nature. Efficiency of photocoloration process is more than one order of magnitude higher than the photobleaching quantum yield. Owing to the presence of a benzoxazole fragment ionochromic properties allow detecting presence of such metal cations as Co2+, Ni2+, Zn2+,Cu2+, Cd2+. Exemplified by Ni2+, Zn2+ ionochromic effect has been quantitatively described. Combination of photochromism and ionochromism in the obtained spiropyrans afford an opportunity to create metal ion chemosensor with photodriven recognition function.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1075705-01-9, in my other articles. Computed Properties of C7H7FN2O3.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Application of 590-67-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 590-67-0, Name is 1-Methylcyclohexanol, SMILES is OC1(C)CCCCC1, belongs to benzoxazole compound. In a article, author is Jilani, Jamal Abdellatif, introduce new discover of the category.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME 2-ARYLBENZOXAZOLE ACETIC ACID DERIVATIVES AS PROMISING ANTICANCER AGENTS

The synthesis of a series of 2-arylbenzoxazole compounds possessing a cytotoxic activity as potential anticancer agents was achieved. Oxidative coupling of benzaldehyde with o-aminophenol utilizing lead tetraacelate approach was used to realize the synthesis of compounds 1-11. The cytotoxicity of 1-11 was screened against breast cancer cell line MCF-7 and human colon cancer cell line HCT-116 utilizing doxorubicin as a reference drug. Among these compounds, 2-(3-benzyloxyphenyl)benzoxazole-5-acetic acid (5) and 2-(4-methoxyphenyl)benzoxazol-5-acetic acid (10), were found to be promising cytotoxic compounds against the MCF-7 cell line. In addition, this study showed that the presence of an acetic acid group at position 5 of the benzoxazole nucleus enhances the activity. Moreover, we noticed that the presence of an oxygen atom directly linked to the phenyl substituent improves activity as well. These results offer a new benzoxazole based template to design and develop novel antineoplastic agents.

Application of 590-67-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 590-67-0 is helpful to your research.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, COA of Formula: C2BF2LiO4, 409071-16-5, Name is Lithium difluoro(oxalato)borate, SMILES is O=C(O[B-](F)(F)O1)C1=O.[Li+], belongs to benzoxazole compound. In a document, author is Labib, Madlen B., introduce the new discover.

Azole-hydrazone derivatives: Design, synthesis, in vitro biological evaluation, dual EGFR/HER2 inhibitory activity, cell cycle analysis and molecular docking study as anticancer agents

In this research, three series of azole-hydrazone derivatives namely, benzimidazole, benzoxazole and benzothiazole were designed and synthesized. Their structures were confirmed by elemental analysis and spectroscopic techniques. Stereochemical configuration of the synthesized compounds (Z/E) was determined. The new derivatives were tested in vitro against both human breast adenocarcinoma (MCF-7) and human hepatic adenocarcinoma (HepG2) cell lines. The most active compounds 3h (IC50 = 0.067 mu M against MCF-7) and 3l (IC50 = 0.027 mu M against HepG2) were further tested for Epidermal Growth Factor Receptor (EGFR) inhibitory activity. The most active 3h on EGFR was then screened for HER2 and VEGFR enzymes. Caspase-3/9 protein level expression were measured for the two compounds 3h and 3l. Cell cycle analysis showed pre G1 apoptosis and cell cycle arrest at G2/M phase. Up-regulation of Bax and down-regulation of Bcl-2 protein expression level confirmed apoptosis. Molecular docking analysis was performed for all the synthesized compounds inside the active site of EGFR. (C) 2017 Elsevier Inc. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 409071-16-5. COA of Formula: C2BF2LiO4.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry, like all the natural sciences, SDS of cas: 530-62-1, begins with the direct observation of nature¡ª in this case, of matter.530-62-1, Name is Di(1H-imidazol-1-yl)methanone, SMILES is O=C(N1C=CN=C1)N2C=CN=C2, belongs to benzoxazole compound. In a document, author is Chaurasia, Shivkumar R., introduce the new discover.

CuNiFe a Magnetic Nano-Catalyst: an Efficient Catalyst for the Selective Synthesis of Benzoxazoles

An efficient protocol for the synthesis of benzoxazoles from o-nitrophenols and benzyl alcohols using CuNiFe as a magnetic nano-catalyst via hydrogenation transfer has been described. The CuNiFe magnetic nano-catalyst was prepared by an operationally simple method, without the use of any toxic reagents. The prepared catalyst was characterized by XRD, FEG-SEM, EDAX, TEM, and FT-IR techniques. No additional additives such as oxidants and reductants were required for this reaction. CuNiFe magnetic nano-catalyst showed good air stability and could be recycled up to six times without any significant loss in its catalytic activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 530-62-1. SDS of cas: 530-62-1.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 540-36-3, Name is 1,4-Difluorobenzene, SMILES is FC1=CC=C(F)C=C1, in an article , author is Zhong, Wenying, once mentioned of 540-36-3, Application In Synthesis of 1,4-Difluorobenzene.

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells

Benzoxazole derivative K313 has previously been reported to possess anti-inflammatory effects in lipopolysaccharide-induced RAW264.7 macrophages. To date, there have been no related reports on the anticancer effects of K313. In this study, we found that K313 reduced the viability of human B-cell leukemia (Nalm-6) and lymphoma (Daudi) cells in a dose-dependent manner without affecting healthy peripheral blood mononuclear cells (PBMCs) and induced moderate cell cycle arrest at the G0/G1 phase. Meanwhile, K313 mediated cell apoptosis, which was accompanied by the activation of caspase-9, caspase-3, and poly ADP-ribose polymerase (PARP). Furthermore, cells treated with K313 showed a significant decrease in mitochondrial membrane potential (MMP), which may have been caused by the caspase-8-mediated cleavage of Bid, as detected by Western blot analysis. We also found that K313 led to the downregulation of p-p70S6K protein, which plays an important role in cell survival and cell cycle progression. In addition, treatment of these cells with K313 blocked autophagic flux, as reflected in the accumulation of LC3-II and p62 protein levels in a dose- and time-dependent manner. In conclusion, K313 decreases cell viability without affecting normal healthy PBMCs, induces cell cycle arrest and apoptosis, reduces p-p70S6K protein levels, and mediates strong autophagy inhibition. Therefore, K313 and its derivatives could be developed as potential anticancer drugs or autophagy blockers in the future.

Interested yet? Read on for other articles about 540-36-3, you can contact me at any time and look forward to more communication. Application In Synthesis of 1,4-Difluorobenzene.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2892-51-5, Name is 3,4-Dihydroxy-3-cyclobutene-1,2-dione, molecular formula is C4H2O4. In an article, author is Xiao, Yan,once mentioned of 2892-51-5, Application In Synthesis of 3,4-Dihydroxy-3-cyclobutene-1,2-dione.

Metal-free C-H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source

A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system.

Interested yet? Keep reading other articles of 2892-51-5, you can contact me at any time and look forward to more communication. Application In Synthesis of 3,4-Dihydroxy-3-cyclobutene-1,2-dione.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Synthetic Route of 51-67-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 51-67-2, Name is Tyramine, SMILES is C1=C(C=CC(=C1)O)CCN, belongs to benzoxazole compound. In a article, author is Yang, Xiaofeng, introduce new discover of the category.

TBET-based ratiometric fluorescent probe for Hg2+ with large pseudo-Stokes shift and emission shift in aqueous media and intracellular colorimetric imaging in live Hela cells

The detection of Hg2+ in biological systems and its imaging is of highly importance. In this work, a novel ratiometric fluorescence probe is developed based on through-bond energy transfer (TBET) with a 2-(2-hydroxyphenyl)benzoxazole (HBO) as donor and a Rhodamine derivative-Hg conjugate (RDM-Hg) as acceptor. Hg2+ weakens the fluorescence of HBO at 430 nm and meanwhile interacts with Rhodamine B derivative to form a fluorescent conjugate (RDM-Hg) giving rise to emission at 597 nm with a 167 nm red-shift. Further, the difference 282 nm between the donor absorption (315 nm) and the accepter emission (597 nm) for 1 + Hg2+ is comparable to the highest value of the Stokes shift (282 nm) reported earlier for other reported TBET-based cassette. Through-bond energy transfer from HBO to RDM-Hg is triggered by Hg2+ resulting in concentration dependent variation of fluorescence ratio I-597/I-430. A linear calibration of I-597/I-430 versus Hg2+ concentration is obtained within 0-5 mu M, along with the lowest detection limit being found to be as low as 1.31 x 10(-9) mol center dot l(-1) (similar to 0.26 ppb) for Hg2+. This feature is further demonstrated by colorimetric imaging of test strip and intracellular Hg2+. On the other hand, the HBO/RDM TBET sensing system is characterized by a combination of high sensitivity and selectivity. The present study provides an approach for further development of ratiometric probes dedicated to selective in vitro or in vivo sensing some species of biologically interest.

Synthetic Route of 51-67-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 51-67-2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of 1,4-Difluorobenzene, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 540-36-3, Name is 1,4-Difluorobenzene, molecular formula is C6H4F2. In an article, author is de Paiva, Fernanda C. R.,once mentioned of 540-36-3.

The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family

Adenylate-forming enzymes (AFEs) are a mechanistic superfamily of proteins that are involved in many cellular roles. In the biosynthesis of benzoxazole antibiotics, an AFE has been reported to play a key role in the condensation of cyclic molecules. In the biosynthetic gene cluster for the benzoxazole AJI9561, AjiA1 catalyzes the condensation of two 3-hydroxyanthranilic acid (3-HAA) molecules using ATP as a co-substrate. Here, the enzymatic activity of AjiA1 is reported together with a structural analysis of its apo form. The structure of AjiA1 was solved at 2.0 angstrom resolution and shows a conserved fold with other AFE family members. AjiA1 exhibits activity in the presence of 3-HAA (K-m = 77.86 +/- 28.36, k(cat) = 0.04 +/- 0.004) and also with the alternative substrate 3-hydroxybenzoic acid (3-HBA; K-m = 22.12 +/- 31.35, k(cat) = 0.08 +/- 0.005). The structure of AjiA1 in the apo form also reveals crucial conformational changes that occur during the catalytic cycle of this enzyme which have not been described for any other AFE member. Consequently, the results shown here provide insights into this protein family and a new subgroup is proposed for enzymes that are involved in benzoxazole-ring formation.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 75178-96-0, Name is tert-Butyl (3-aminopropyl)carbamate, molecular formula is , belongs to benzoxazole compound. In a document, author is Murata, Yuki, Application In Synthesis of tert-Butyl (3-aminopropyl)carbamate.

Synthesis of 2-(arylsulfenyl)azoles by copper-catalyzed S-arylation of azole-2-thiones with triarylbismuthines

A simple approach for the S-arylation of azole-2-thiones with trivalent organobismuth reagents is described. The reaction of azole-2-thiones containing a heterocyclic ring (benzothiazole, benzoxazole, benzimidazole, and pyrimidine) with triarylbismuthines in the presence of CuI (10 mol%) and 1,10-phenanthroline (10 mol%) under aerobic conditions afforded S-arylated coupling products in moderate-to-high yields. Triarylbismuthines gave better results compared to various aryl donors based from other typical elements such as antimony, silicon, tin, and tellurium. This reaction is the first example of the Cu-catalyzed S-arylation of azole-2-thiones using an organobismuth compound.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 75178-96-0, in my other articles. Application In Synthesis of tert-Butyl (3-aminopropyl)carbamate.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 392-56-3, Name is Hexafluorobenzene, molecular formula is C6F6. In an article, author is Wang, Lifei,once mentioned of 392-56-3, Recommanded Product: 392-56-3.

A density functional theory-time-dependent density functional theory investigation of photo-induced hydrogen bond and proton transfer for 2-(3,5-dichloro-2,6-dihydroxy-phenyl)-benzoxazole-6-carboxylicacid

Given the paramount importance of excited-state relaxation in the photochemical process, excited-state hydrogen bonding interactions and excited-state intramolecular proton transfer (ESIPT) are always hot topics. In this work, we theoretically explore the excited-state dynamical behaviors for a novel 2-(3,5-dichloro-2,6-dihydroxy-phenyl)-benzoxazole-6-carboxylicacid (DDPBC) system. As two intramolecular hydrogen bonds (O1-H2MIDLINE HORIZONTAL ELLIPSISN3 and O4-H5MIDLINE HORIZONTAL ELLIPSISO6) exist in the DDPBC structure, we first check if the double proton transfer form cannot be formed in the S1 state. Then, we explore the changes of geometrical parameters involved in hydrogen bonds, based on which we confirm that the dual intramolecular hydrogen bonds are strengthened on photo-excitation. The O1-H2MIDLINE HORIZONTAL ELLIPSISN3 hydrogen bond particularly plays a more important role in excited state. When it comes to the photo-induced excitation, we find charge transfer and electronic density redistribution around O1-H2 and N3 atom moieties. We verify the ESIPT tendency arising from the O1-H2MIDLINE HORIZONTAL ELLIPSISN3 hydrogen bond. In the analysis of the potential energy curves, along with O1-H2MIDLINE HORIZONTAL ELLIPSISN3 and O4-H5MIDLINE HORIZONTAL ELLIPSISO6, we demonstrate that the ESIPT reaction should occur along with O1-H2MIDLINE HORIZONTAL ELLIPSISN3 rather than O4-H5MIDLINE HORIZONTAL ELLIPSISO6. This work not only clarifies the specific ESIPT mechanism for DDPBC system but also paves the way for further novel applications based on DDPBC structure in the future.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem