Tag: M.W:100-200

A common heterocyclic compound, the benzoxazole compound, name is 5-Chlorobenzo[d]oxazole-2(3H)-thione,cas is 22876-19-3, mainly used in chemical industry, its synthesis route is as follows.,22876-19-3

Thionyl chloride (885 g, 7.5 mol)And N, N-dimethylformamide (270 ml) were added to a solution of 5-chloro-2-mercaptobenzoxazole (540 g, 2.903 mol) in dichloromethane (5 L) at 5-10 C.Stirred until a clear solution was formed and the reaction solution was stirred at room temperature for 4 hours.After completion of the reaction, the reaction solution was poured into 4 L of ice water, neutralized to neutral with sodium bicarbonate in 1 hour, and extracted with dichloromethane (2.5 L * 2).The organic layer was washed with brine, dried over sodium sulfate and dried to give the crude product. The crude product was washed with n-hexane (2 L * 2) at -20 C, filtered and dried to give yellow liquid 2,5-dichlorobenzo (496.8 g, 91.0%).

As the rapid development of chemical substances, we look forward to future research findings about 22876-19-3

Reference£º
Patent; Shanghai ZaiQi Bio-Tech Co., Ltd.; Wang, Zhiguo; Song, Yanhong; Ma, Xiujuan; Tian, Beibei; Li, Shijiang; Li, Chao; Li, Qiang; Li, Tao; (8 pag.)CN106478537; (2017); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

A common heterocyclic compound, the benzoxazole compound, name is 5-Chlorobenzo[d]oxazole-2(3H)-thione,cas is 22876-19-3, mainly used in chemical industry, its synthesis route is as follows.,22876-19-3

General procedure: A mixture of intermediate compound N-(3-(1H-tetrazole-5-yl) phenyl)-2-chloroacetamideand benzo[d]oxazole-2-thiol or benzo[d]thiazole-2-thiol or 2-mercapto benzimidazoles in anequimolar amount were taken and refluxed with acetone (20 mL) in the presence of K2CO3for 24 hr. The reaction was monitored by TLC and on completion of the reaction, an excessof solvent was evaporated at room temperature and the reaction mixture was diluted withwater (about 200 mL). The diluted hydrochloric acid was added to precipitate the productwhich was further filtered and thoroughly washed with cold water.

As the rapid development of chemical substances, we look forward to future research findings about 22876-19-3

Reference£º
Article; Maheshwari, Neelesh; Karthikeyan, Chandrabose; Bhadada, Shraddha V.; Verma, Amit K.; Sahi, Chandan; Moorthy, N.S. Hari Narayana; Trivedi, Piyush; Bioorganic Chemistry; vol. 92; (2019);,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

A common heterocyclic compound, the benzoxazole compound, name is 5-Fluoro-2-methylbenzo[d]oxazole,cas is 701-16-6, mainly used in chemical industry, its synthesis route is as follows.,701-16-6

[0614] To a stirred solution of Comp-50c (0.073 g, 0.48 mmol) in mixture of THF (5 mL) and tBuOH (0.5 mL) was added t-BuOK (0.16 g, 1.46 mmol) at 0 C. Comp-80b (0.1 g, 0.48 mmol) was added portion wise and the reaction mixture was stirred at RT for 16 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was quenched with H20 (5 mL) and extracted with EtOAc (10 mL X 2). The organic layer was washed with brine, separated, dried over anhydrous Na2SC>4 and concentrated under reduced pressure. The crude obtained was purified by column chromatography (silica, 100- 200 mesh, 2-5% EtOAc in hexane) to afford (E)-2-(2-(l-cyclohexyl-2,5-dimethyl-lH-pyrrol- 3-yl)vinyl)-5-fluorobenzo[d]oxazole (104, 0.08 g, 51%) as a yellow solid. (1076) [0615] HPLC Purity: 99.4% (1077) [0616] MS (ESI) m/e [M+H]+/ Rt’%: 339.15/2.56/99.8% (1078) [0617] 1H NMR (400 MHz, DMSO-d6) delta 1.17 – 1.27 (m, 2 H), 1.35 – 1.45 (m, 2 H), 1.62 – 1.69 (m, 1 H), 1.73 – 1.96 (m, 6 H), 2.22 – 2.27 (m, 3 H), 2.35 – 2.39 (m, 3 H), 6.20 – 6.25 (m, 1 H), 6.46 – 6.53 (m, 1 H), 7.09 – 7.16 (m, 1 H), 7.41 – 7.48 (m, 1 H), 7.60 – 7.66 (m, 1 H), 7.66 – 7.70 (m, 1 H).

As the rapid development of chemical substances, we look forward to future research findings about 701-16-6

Reference£º
Patent; ALPINE ANDROSCIENCES, INC.; PATIL, Santhosh N.; SARMA, Bugga VNBS; (148 pag.)WO2019/152731; (2019); A1;,
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81900-93-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81900-93-8,4-Aminobenzo[d]oxazol-2(3H)-one,as a common compound, the synthetic route is as follows.

Commercially available 4-fluoro-2-trifluoromethylbenzylamine (0.5 ml, 3.7 mmol) was dissolved in 20 ml of AcOEt and at 0C triphosgene (1.12 g, 3.7 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (5ml) of compound lb (360 mg, 2.4 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 4 / petroleum ether 6). The solvent was evaporated and the crude was dissolved in AcOEt (30ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 90 mg of a white solid. Yield = 10% ‘HNMR (DMSO, 200 MHz) delta 4.36 (2H, d, J = 5.6 Hz), 6.71 (1H, t, J = 6 Hz), 6.98 (2H, m), 7.56 (4H, m), 8.55 (1H, bs), 1 1.09 (1H, bs); [M+1] 370.2 (C16HnF4N3O3 requires 369.27).

As the paragraph descriping shows that 81900-93-8 is playing an increasingly important role.

Reference£º
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
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Benzoxazole | C7H5NO – PubChem

132244-31-6, 5-Bromobenzo[d]oxazole is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromobenzo[d]oxazole (1.2 g, 6.06 mmol, 1 eq.) in DMF (10 mL) was added 5-(4,4,5,5-Bis(pinacolato)diboron (1.68 g, 1.66 mmol, 1.1 eq.), KOAc (1.7 g, 18.09 mmol, 3 eq.), and PdCl2(dppf)?DCM complex (247 mg, 0.23 mmol, 0.05 eq.). The reaction mixture was deoxygenated with N2 and the reaction mixture was stirred at 80 C. for 18 h. The progress of the reaction was monitored by LCMS The reaction mixture was cooled to RT, diluted with water (50 mL) and extracted with ethyl acetate (2*50 mL). Combined organic layer was washed with brine (20 mL) and dried over sodium sulfate. Removal of solvent under reduced pressure gave crude which was purified by flash chromatography(0-100% Hexane-EtOAc) to afford 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (0.900 g, 60%) as off white solid. LCMS: 245, 247 [M+1]+

132244-31-6, 132244-31-6 5-Bromobenzo[d]oxazole 21749504, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; GiraFpharma LLC; PHAM, Son Minh; CHEN, Jiyun; ANSARI, Amantullah; JADHAVAR, Pradeep S.; PATIL, Varshavekumar S.; KHAN, Farha; RAMACHANDRAN, Sreekanth A.; AGARWAL, Anil Kumar; CHAKRAVARTY, Sarvajit; (120 pag.)US2019/23666; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

81900-93-8,81900-93-8, 4-Aminobenzo[d]oxazol-2(3H)-one is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1854.96 kg of 99.1% pure 4-amino-2-benzoxazolone (V) 763.2 kg of isopropanol, 9274.8 kg of ethyl acetate, 10500 kg of sulfuric acid, 869.8 kg of sodium nitrite, 12.1 kg of copper(II) sulfate were mixed and stirred. The temperature was raised until the end of the reaction; the layer was allowed to stand, and ethyl acetate was distilled off to obtain 1544.6 kg of 2-benzoxazolone (VI) having a purity of 99.3% in a yield of 92.7%.

The synthetic route of 81900-93-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shao Yutian; (12 pag.)CN110156712; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4570-41-6,Benzo[d]oxazol-2-amine,as a common compound, the synthetic route is as follows.,4570-41-6

Amide-containing compounds with (benz)imidazol-2-yl groups can undergo catalytic directed cleavage with an alcohol nucleophile 11 in the presence of a metal catalyst. The following examples as depicted in Example Scheme ES can be listed:_Using 15.0 molpercent Zn(OAc)2.17H20, 1.0 equiv 9a, 6.0 equiv 16, tBuOAc, 100 ¡ãC, 48 h.1,3-bis(Benzo[d]oxazol-2-yl)urea (18a) was obtained in 59percent (0.087 g, 0.296 mmol) yield. White crystals ; m.p. 130 ¡ãC. 13C-NMR (100 MHz, DMSO-d6): : 162.7 (Cquat), 147.8 (Cquat), 143.4 (Cquat),123.4 (CH), 119.9 (CH), 115.3 (CH), 108.3 (CH).

4570-41-6 Benzo[d]oxazol-2-amine 20707, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITEIT ANTWERPEN; MAES, Bert; WYBON, Clarence; CHEN, Chen; BHEETER, Charles Beromeo; SERGUEEV, Serguei; (88 pag.)WO2017/46133; (2017); A1;,
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Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.701-16-6,5-Fluoro-2-methylbenzo[d]oxazole,as a common compound, the synthetic route is as follows.

701-16-6, 5-Fluoro-2-Methyl-6-Nitrobenzoxazole (10) Concentrated sulfuric acid (60 mL) was stirred mechanically and cooled in an ice/water bath. To this was gradually added 5-fluoro-2-methylbenzoxazole (9), (20 g, 0.132 Moles), at such a rate that the temperature stayed at 15-20 C., over a 15-20 minute period. A solution of concentrated sulfuric acid (11 mL), and concentrated nitric acid (10 mL), was prepared and added drop by drop to the benzoxazole solution at such a rate that the temperature was maintained at approximately 10 C.

701-16-6 5-Fluoro-2-methylbenzo[d]oxazole 2769350, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; Eastman Kodak Company; US2005/101784; (2005); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13673-62-6,2-(Methylthio)benzo[d]oxazole,as a common compound, the synthetic route is as follows.

Ethyl N-(2-benzoxazolyl)-O-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-tyrosinate (3-1) A mixture constituted by 1-4 (120 mg, 0.3 mmole) and 2-methylthiobenzoxazole (0.5 ml) and 30 mg of mercury dichloride is heated at 140 C. for 3 hours, followed by evaporating under reduced pressure and purifying by chromatography eluding with a gradient of AcOEt (0—>100) in CH2Cl2 in order to obtain 55 mg of the expected 3-1. IR (CHCl3) NH 3424 cm-1 (Max); C=O 1735 cm-1; conjugated system+Aromatic 1644, 1599, 1583, 1512 cm-1., 13673-62-6

As the paragraph descriping shows that 13673-62-6 is playing an increasingly important role.

Reference£º
Patent; Demassey, Jacques; Gourvest, Jean-Francois; Ruxer, Jean-Marie; Weston, John Bernard; LeFrancois, Jean-Michel; US2004/225111; (2004); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

4570-41-6, Benzo[d]oxazol-2-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4570-41-6

2-Bromo-5-fluoropyridine (1 ) (1 .0g, 5.71 mmol), benzo[d]oxazol-2-amine (2) (766mg, 5.71 mmol), Xantphos (0.33g, 0.57mmol), and Cs2C03 (2.79g, 8.56mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was degassed with N2(g) and placed under vacuum for 10min. Pd2(dba)3 (0.261 g, 0.28mmol) was then added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralized water (200ml_), and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 : 1 ) to provide N-(5-fluoropyridin-2-yl)benzo[d]oxazol-2-amine (3) as a yellow solid (0.6g, 46percent). LCMS (ES): Found 230.1 [M+H]+

As the paragraph descriping shows that 4570-41-6 is playing an increasingly important role.

Reference£º
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; WHALE, Andrew David; (145 pag.)WO2017/29514; (2017); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem