Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Furylalkynes. IX. Transformations of furylethynylcarbinol and its derivatives.Synthetic Route of C7H8O2.

A solution of EtMgBr, prepared from 65.4 g. EtBr, in 560 ml. dry tetrahydrofuran (THF) was added dropwise to a solution of acetylene in THF (C2H2 was bubbled into THF 0.5 hr. at 0°). Fresh distilled furfural (54 g.) in the same volume THF was added after 30 min., the mixture was stirred 6 hrs. with simultaneous addition of C2H2, kept overnight, and decomposed with dilute NH4Cl to give 62% Ia, b2 83-5°, n20D 1.5040. Acrylonitrile (2.67 g.) was added to a stirred mixture of 5 g. Ia in 1 ml. 4% KOH at <30°. The mixture was stirred 6 hrs. at room temperature, kept overnight, and extracted with Et2O to yield 79.1% Ib, b0.5 142°, n20D 1.4968. HCl (1-2 drops) was added carefully to a stirred mixture of 5 g. Ia and 4.1 g. vinyl ethyl ether at 0°. The mixture was stirred 1 hr. at 0°, then 1 hr. at room temperature, added to 50 ml. cold H2O, and extracted with Et2O to yield 64% Ic, b2 72°, n20D 1.4695. Ic (5 g.) in 50 ml. EtOH was hydrogenated in the presence of 0.01 g. Raney Ni at room temperature/atm. pressure to give 96% II, b1.5 55-7°, n20D 1.4420. Ic (5 g.), 25 ml. dioxane, 1.26 g. HNMe2, and 1.75 g. paraformaldehyde were boiled 18 hrs. in a sealed tube to yield 4.5 g. Id, b1.5 105-7°, n20D 1.4720. Similarly was prepared 40% Ie, b1 142-3°, n20D 1.4931. An ether solution of 5 g. Ic was added dropwise to a solution of EtMgBr (from 5.6 g. EtBr), the mixture was stirred 7 hrs. at room temperature, kept overnight, 2.7 g. cyclohexanone in the same volume of Et2O was added to the vigorously stirred reaction mixture at 0° which was then stirred 20 hrs. and decomposed with dilute NH4Cl to yield 32% If, b6 125-7°, n20D 1.4900. Active MnO2 (35 g.) was added gradually to a cold solution of 5 g. Ia in 150 ml. Et2O and the mixture stirred 1 hr. at room temperature to give 91% 3-(2-furyl)-1-propyn-3-one (III), m. 43-6°. III (2 g.) was hydrogenated in alc. solution at room temperature to yield 3-(2-furyl)propan-3-one; 2,4-dinitrophenylhydrazone m. 194-6° (aqueous EtOH). III (1 g.) was added to an ether solution of CH2N2 prepared from 5 g. nitrosomethylurea and the mixture was kept overnight to give 76.4% IV, m. 199-200° (benzene-petroleum ether); 2,4-dinitrophenylhydrazone m. 225-6° (EtOH). A mixture of 2 g. III, 1.6 g. Et2NH, and 50 ml. Me2CO was stirred 6 hrs. at room temperature, and kept overnight to yield 76.4% V, b1 142-4°. Similarly were prepared 85.2% VI, b3 150-5°, m. 79-80°, and VII, m. 88-90°. Cu2Cl2 (0.5 g.) and 6 ml. 30% aqueous EtNH2 was added to a cool solution of 3.7 g. Ia in MeOH, 5.5 g. PhC:CBr and 0.1 g. NH2OH.HCl was added, and the mixture was stirred 30 min. at the room temperature KCN (0.1 g.) in 3 ml. H2O was added, the mixture was added to water, extracted with Et2O; the organic layer was stirred 4 hrs. with 60 g. active MnO2 to give 6.5 g. VIII m. 85.5-6.5°. 6 references. The article 《Furylalkynes. IX. Transformations of furylethynylcarbinol and its derivatives》 also mentions many details about this compound(3194-15-8)Synthetic Route of C7H8O2, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of C7H8O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Unusual course of the Meerwein reaction in the furan series. Author is Markova, I. G.; Polievktov, M. K.; Oleinik, A. F.; Modnikova, G. A..

Meerwein reaction of p-XC6H4N2+ Cl- (X = Cl, Br, NO2) with furyl ketones I (R = Me, Et, Pr) gave II and III. II is not an intermediate in the formation of III. Polarog. indicated that RCHO were present in the reaction mixture which agreed with IV as a proposed intermediate; IV lost RCHO to give III.

The article 《Unusual course of the Meerwein reaction in the furan series》 also mentions many details about this compound(3194-15-8)Synthetic Route of C7H8O2, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Sustainable Chemistry & Engineering called Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles, Author is Miao, Chengxia; Hou, Qin; Wen, Yating; Han, Feng; Li, Zhen; Yang, Lei; Xia, Chun-Gu, which mentions a compound: 6797-13-3, SMILESS is CCC1=NC2=CC=CC=C2O1, Molecular C9H9NO, HPLC of Formula: 6797-13-3.

With long-chained acidic ionic liquids as catalysts, a metal-free, efficient, and universal strategy was developed to synthesize a series of benzoazole compounds through intermol. cyclization of 2-aminophenols/thiophenols/anilines with β-diketones. Compared with traditional ionic liquids, the long-chained ionic liquids with certain surfactivity exhibited better catalytic activities perhaps for micellar action and could be reused at least six times. A mechanism that involves condensation, nucleophilic addition, and C-C bond cleavage was proposed, and the imine compound was recognized as an important intermediate in the reaction.

The article 《Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles》 also mentions many details about this compound(6797-13-3)HPLC of Formula: 6797-13-3, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Analytica Chimica Acta called Polarographic study of an alkyl benzimidazolyl sulfoxide and the corresponding sulfide and sulfone, Author is Johansson, Bo Lennart; Persson, Bjorn, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Synthetic Route of C8H8N2S.

2-(5-Methylbenzimidazolyl)-1-(2-pyridyl)ethyl sulfide (I), II [69417-07-8], and III [69417-08-9] were reduced at a dropping Hg electrode in aqueous EtOH. Coulometric experiments at a Hg pool prove that 2-ethylpyridine [100-71-0] and 2-mercapto-5-methylbenzimidazole [27231-36-3] were formed in the reduction process of the sulfide and the sulfoxide. Coulometric reduction of the sulfone results in some conversion of the pyridine 1-oxide group together with a reductive fission of the ethyl-sulfonyl bond. One of these fission products undergoes secondary reactions. The concentration of 2-benzimidazolyl 2-pyridylmethyl sulfoxide (IV) [57237-97-5] in a pharmaceutical formulation was determined by differential pulse polarog.

The article 《Polarographic study of an alkyl benzimidazolyl sulfoxide and the corresponding sulfide and sulfone》 also mentions many details about this compound(27231-36-3)Synthetic Route of C8H8N2S, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

SDS of cas: 3194-15-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about Effect of thermal treatment on the flavor generation from Maillard reaction of xylose and chicken peptide. Author is Liu, Jianbin; Liu, Mengya; He, Congcong; Song, Huanlu; Chen, Feng.

In this research, effect of the thermal treatment on the flavor generation from Maillard reaction of xylose and chicken peptide was studied. In summary, high temperature (>100 °C) could remarkably increase the formation of meaty aroma generated by xylose and chicken peptide through a Maillard reaction system, while lower temperature and longer heating tended to generate a broth-like taste (i.e., umami and kokumi). Pyrazines were the major contributors to the nutty/roast and basic meaty aroma in the Maillard reaction products (MRP), while the Glu released under the low temperature heating was considered an important contributor to the umami taste of MRPs. The low mol. weight peptide (<500 Da) was considered as the main contributor of the generation of pyrazines and 2-furfurylpyrrole, which could be due to the high reaction activity of the amidogen in these compounds In addition, crosslinking compounds with mol. weight >1000 Da formed from peptides <500 Da in the low temperature heating might be involved in formation of important kokumi-active compounds, while the high mol. compounds MRPs >3000 Da were very likely responsible for the bitter taste.

The article 《Effect of thermal treatment on the flavor generation from Maillard reaction of xylose and chicken peptide》 also mentions many details about this compound(3194-15-8)SDS of cas: 3194-15-8, you can pay attention to it, because details determine success or failure

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Catalytic synthesis of 2-alkylbenzoxazoles》. Authors are Kozlov, N. S.; Kiselev, B. I..The article about the compound:2-Ethylbenzo[d]oxazolecas:6797-13-3,SMILESS:CCC1=NC2=CC=CC=C2O1).Reference of 2-Ethylbenzo[d]oxazole. Through the article, more information about this compound (cas:6797-13-3) is conveyed.

A mixture of 0.1 mole o-nitrophenol and 0.3 mole ROH( R = alkyl) was passed at the rate of 20 g./hr. over Cu-Al2O3 catalyst kept at 300-10°, unreacted material distilled and the residue worked up with alkali, washed with H2O, and dried to yield 2-alkylbenzoxazoles (R, b.p./mm., d20, n20D, and % yield given): H, 180-2°/760, -,-, 20; Me, 201°/760, 1.12, 1.5531, 31; Et, 98-9°/10, 1.0879, 1.5420, 34; Pr, 116-18°/10, 1.066, 1.5338, 69; iso-Pr, 109-11°/10, 1.0799, 1.5391, 32; Bu, 133-5°/10, 1.042, 1.5271, 21; iso-Bu, 120-2°/10, 1.028, 1.5090, 15; C5H11, 145-7°/10, 1.0072, 1.5173, 30; C6H13, 164-5°/10, 0.983, 1.5000, 25; C7H15, 176-8°/10, 0.943, 1.4818, 30; C8H17 (m. 26°), -, -, 27; and C9H19, (m. 22-3°), -, -, 20. Ir spectra are discussed.

Different reactions of this compound(2-Ethylbenzo[d]oxazole)Reference of 2-Ethylbenzo[d]oxazole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Chromatography A called Elucidation of the aroma compositions of Zhenjiang aromatic vinegar using comprehensive two dimensional gas chromatography coupled to time-of-flight mass spectrometry and gas chromatography-olfactometry, Author is Zhou, Zhilei; Liu, Shuangping; Kong, Xiangwei; Ji, Zhongwei; Han, Xiao; Wu, Jianfeng; Mao, Jian, which mentions a compound: 3194-15-8, SMILESS is O=C(C1=CC=CO1)CC, Molecular C7H8O2, Computed Properties of C7H8O2.

In this work, a method to characterize the aroma compounds of Zhenjiang aromatic vinegar (ZAV) was developed using comprehensive two dimensional gas chromatog. (GC × GC) coupled with time-of-flight mass spectrometry (TOFMS) and gas chromatog. olfactometry (GC-O). The column combination was optimized and good separation was achieved. Structured chromatograms of furans and pyrazines were obtained and discussed. A total of 360 compounds were tentatively identified based on mass spectrum match factors, structured chromatogram and linear retention indexes comparison. The most abundant class in number was ketones. A large number of esters, furans and derivatives, aldehydes and alcs. were also detected. The odor-active components were identified by comparison of the reported odor of the identified compounds with the odor of corresponding GC-O region. The odorants of methanethiol, 2-methyl-propanal, 2-methyl-butanal/3-methyl-butanal, octanal, 1-octen-3-one, di-Me trisulfide, trimethyl-pyrazine, acetic acid, 3-(methylthio)-propanal, furfural, benzeneacetaldehyde, 3-methyl-butanoic acid/2-methyl-butanoic acid and phenethyl acetate were suspected to be the most potent. About half of them were identified as significant aroma constituents in ZAV for the first time. Their contribution to specific sensory attribute of ZAJ was also studied. The results indicated that the presented method is suitable for characterization of ZAV aroma constituents. This study also enriches our knowledge on the components and aroma of ZAV.

Different reactions of this compound(1-(Furan-2-yl)propan-1-one)Computed Properties of C7H8O2 require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of mixed organomagnesium compounds on N-disubstituted amides of α-furoic acid》. Authors are Maxim, N.; Zugravescu, I.; Fulga, I..The article about the compound:1-(Furan-2-yl)propan-1-onecas:3194-15-8,SMILESS:O=C(C1=CC=CO1)CC).Category: benzoxazole. Through the article, more information about this compound (cas:3194-15-8) is conveyed.

In aromatic series of keto amides, BzNR2, the action of the Grignard reagent produces ketones except in the instance of BzNEt2, where PhMgBr gave in addition Ph3CNEtPh (Busch and Fleischmann, C. A. 4, 3237). The action of the Grignard reagent has been studied on furoylanilides prepared by the action of α- furoyl chloride (I) on PhNHMe, PhNHEt and Ph2NH. A mixture of 136 g. PhNHMe and 250 g. of anhydrous benzene was treated dropwise with 83 g. I. The filtered benzene solution was washed, dried and evaporated and the crude product was recrystallized from benzene or alc., yielding 90% of α-furoyl-N-methylanilide (II), C12H11NO2, m. 120°. Similarly were prepared the corresponding ethylanilide (III), m. 127°, and diphenylamide (IV), C17H13NO2, m. 157°, in 90 and 80% yields, resp. II (20 g.) was added portionwise with stirring to 35 g. EtMgBr in 160 g. Et2O and, after 12 h., the product was decomposed with 25% HCl. The Et2O layer yielded a crude product, b63 100-40°, which was washed with 30% HCl and extracted with Et2O, giving 4 g. of α- furyl Et ketone (V), b63 120°; semicarbazone, m. 172°. Treatment of II with iso-BuMgCl similarly gave α- furyl iso-Bu ketone (VI), b26 110°; semicarbazone, m. 174°. With III, EtMgBr and iso-BuMgCl gave only V and VI but the crude product obtained by the action of PhMgBr yielded α- furyl Ph ketone (VII), b25 197°, and the tertiary base, ethyl(furyldiphenylmethyl)aniline, C25H23NO, m. 181°. Treatment of III with o-MeC6H4MgBr gave the oily α- furyl o-tolyl ketone (VIII), C12H10O2, b22 177°. Similarly with IV, the Grignard reagents EtMgBr, iso-BuMgCl, o-MeC6H4MgBr and PhMgBr produced V, VI, VIII and VII. The behavior of the furyl series of keto amides is thus analogous to that of the aromatic series in every respect.

Different reactions of this compound(1-(Furan-2-yl)propan-1-one)Category: benzoxazole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Chemical and Pharmaceutical Research called Solvent extraction of palladium(II) with 2-hexyl-5-methyl benziminazole sulfide, Author is Liu, Yan; Huang, Zhangjie; Chen, Muhan; Chen, Lei, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Related Products of 27231-36-3.

A new extractant of 2-hexyl-5-Me benziminazole sulfide (HMBMS) was synthesized and used in the extraction of Pd(II) from hydrochloric acid solution Pd(II) was extracted quant. with HMBMS in kerosene. Thiourea solution could be used as stripping agent. Extraction parameters of Pd(II), including 2-hexyl-5-Me benziminazole sulfide (HMBMS) concentration, contact time of aqueous and organic phases, organic/aqueous (O/A) phase ratio and hydrochloric acid concentration of aqueous phase, were studied in detail. The extraction saturation capacity of Pd(II) was determined from 0.1mol L-1 HCl solution with 30% (volume/volume) HMBMS and its exptl. value exceeded 10 g L-1 under the exptl. conditions. Pd(II) and Pt(IV) could be separated effectively and the separation coefficient of Pd(II) and Pt(IV) (ssPd/Pt) reached 1.5×104 when HMBMS and HC1 concentration were fixed at 20% (V/V) and 0.1 mol L-1, resp. Stripping of Pd(II) from loaded organic phase was performed using thiourea solution

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)Related Products of 27231-36-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Benzimidazole-2-thione and benzoxazole-2-thione derivatives as corrosion inhibitors for aluminum in hydrochloric acid.Quality Control of 2-Mercapto-5-methylbenzimidazole.

The effect of benzimidazole-2-thione and benzoxazole-2-thione derivatives on the corrosion of aluminum in 0.1 M HCl has been investigated by using a potentiostatic polarization technique. Inhibition efficiencies followed the order benzimidazole-2-thione > 5-Me benzimidazole-2-thione > 5-chloro benzimidazole-2-thione, while that of benzoxazole-2-thione derivatives followed the order 5-methylbenzoxazole-2-thione > benzoxazole-2-thione > 5-chlorobenzoxazole-2-thione > 5-nitrobenzoxazole-2-thione. The inhibitor action of these heterocyclic compounds was mainly due to adsorption on the metal surfaces, which show parallelism with the calculated total neg. charge of each of the mols. Thermodn. parameters, such as free energy of adsorption and equilibrium constant were determined Activation energy, activation enthalpy and activation entropy were determined from the corrosion currents measured at different temperatures

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)Quality Control of 2-Mercapto-5-methylbenzimidazole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem