M.W=200-250 | Heterocyclic Building Blocks-Benzoxazole

Cheng, Hanchao’s team published research in Synlett in 2016-03-31 | CAS: 145026-07-9

Copper-Catalyzed Oxidative ¦Á-Ketoacylations of Sulfoximines with Aryl Methyl Ketones and Dioxygen as Terminal Oxidant. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

An efficient copper-catalyzed C-H/N-H bond functionalization for the synthesis ¦Á-keto-N-acyl sulfoximines from aryl Me ketones and NH-sulfoximines with mol. oxygen as terminal oxidant has been developed. E.g., under an atm. of dioxygen, CuBr in DMSO catalyzed the reaction of PhCOMe and PhSMe(O)(:NH) to give 74% PhCOCON:SMePh(O).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mattar, Valeria Tapia’s team published research in Pesticide Biochemistry and Physiology in 2022-07-31 | CAS: 483-76-1

Insecticidal activity of the essential oil of Schinus areira against Rhipibruchus picturatus (F.) (Coleoptera: Bruchinae), and its inhibitory effects on acetylcholinesterase. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

During the storage of Prosopis alba pods, substantial quant. and qual. losses were observed One of the main factors is the seed beetle Rhipibruchus picturatus. A key strategy to develop new pest control management is the use of essential oils (EOs) due they are efficient, less toxic, and less persistent in the environment compared to synthetic pesticides. In this context, seeds and leaves of Schinus areira L. (Anacardiaceae) EOs and Citrus spp. EO were studied in the present work. In the leaves of S. areira EO, 1-epi-cadinol, sesquiterpenoid alc., was the major compound On the other hand, the main compounds of the EO extracted from S. areira seeds are the monoterpenes sabinene, and ¦Á-pinene. Finally, in the Citrus EO, limonene is the principal component. The three EOs obtained exhibited insecticidal activity against R. picturatus, being the first report of the use of EOs against this insect pest. The best insecticidal results were obtained with the leaves of S. areira EO. Moreover, this EO inhibits the acetylcholinesterase enzyme in vitro assays. Mol. docking studies on acetylcholinesterase (AChE) suggest that the main components of the leaves of S, areira EOs, bind to the active site of the enzyme, in good agreement with in vitro competitive inhibition against AChE observed for this EO. The data obtained demonstrate the potential use of Schinus areira EOs in the development of new storage pest control strategies.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Xie, Haisheng’s team published research in Advanced Synthesis & Catalysis in 2018 | CAS: 145026-07-9

Ru (II)-Catalyzed Coupling-Cyclization of Sulfoximines with alpha-Carbonyl Sulfoxonium Ylides as an Approach to 1,2-Benzothiazines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

A Ru(II)-catalyzed approach for the rapid assembly of 1,2-benzothiazines has been developed to enable the coupling-cyclization of aryl Csp2-H bonds with ¦Á-carbonyl sulfoxonium ylides via Csp2-H activation process. The present method could be further applied to the construction of the 4-substituted 1,2-benzothiazine skeletons.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sharma, Nidhi’s team published research in RSC Advances in 2016 | CAS: 145026-07-9

Palladium nanoparticles catalyzed aroylation of NH-sulfoximines with aryl iodides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

A novel approach towards aroylation of NH-sulfoximines using Pd nanoparticles stabilized by a binaphthyl backbone (Pd-BNP) was developed. This synthetic protocol involved the Pd-BNP promoted carbon monoxide insertion of aryl iodides to form an aroyl intermediate which further reacted with NH-sulfoximines to form N-aroyl sulfoximine derivatives in good to excellent yields. The Pd-BNP catalyst was recovered and reused up to six times.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Bisht, Manisha’s team published research in Chemistry of Natural Compounds in 2022-09-30 | CAS: 483-76-1

Composition of Essential Oil from the Aerial Part of Aster peduncularis. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

This article illustrates identification of composition of essential oil from Aster peduncularis. The aerial parts of A. peduncularis were collected from Berinag in the district of Pithoragarh, Uttarakhand, India, in August 2019, at the flowering stage. Essential oil was obtained from ground aerial parts of the plant by hydrodistillation for 5 h using a Clevenger-type apparatus and analyzed by GC and GC-MS. GC and GC-MS anal. of the essential oil showed the presence of 28 components representing 92.6% of the total oil composition The oil was found to be rich in monoterpene hydrocarbons (59.5%), oxygenated sesquiterpenes (17%) and sesquiterpene hydrocarbons (13.5%).

Composition of Essential Oil from the Aerial Part of Aster peduncularis. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chen, Wei’s team published research in Food Control in 2022-10-31 | CAS: 483-76-1

Understanding the aroma diversity of Dancong tea (Camellia sinensis) from the floral and honey odors: Relationship between volatile compounds and sensory characteristics by chemometrics. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Dancong is a Chinese oolong tea famous for its aroma diversity. However, this diversity in characteristic is challenging to be clarified in either sensory or chem. aspects. In this study, the aromas from Dancong teas were characterized based on the typical odors of “”floral”” and “”honey””. The volatile compounds underlying the odors were investigated through chemometrics. Seventy Dancong teas of various categories were collected to approx. the diversity in aroma. According to the sensory evaluation, the floral or honey odor was detected in every sample. For volatile characterization, 57 compounds were identified by gas chromatog.-mass spectrometry (GC-MS) coupled with headspace-solid phase microextraction (HS-SPME) across samples. The difference in floral and honey odors was related to volatile variation among the teas, as both the odor-based classification and the volatile-based unsupervised learning analyses yielded consistent sample clustering patterns. Nine volatiles were identified as putative markers for the odor difference, where indole, (E)-nerolidol, 2-phenylacetonitrile, and ¦Ã-caprolactone accounted for the floral odor predominance, while hexyl 2-methylbutanoate, (Z)-3-hexenyl pentanoate, (Z)-linalool oxide (pyranoid), (E)-linalool oxide (furanoid), and (Z)-linalool oxide (furanoid) contributed to the honey odor perception. These results point to a volatile-endorsed categorization framework based on the floral and honey odors that can assist in Dancong aroma quality control.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Dong, Wanrong’s team published research in Angewandte Chemie, International Edition in 2013 | CAS: 145026-07-9

Rhodium-Catalyzed Oxidative Annulation of Sulfoximines and Alkynes as an Approach to 1,2-Benzothiazines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1,2-Benzothiazines were prepared by rhodium-catalyzed oxidative annulation of sulfoximines and alkynes. E.g., in presence of [Cp*Rh(MeCN)3][BF4]2 and Fe(OAc)2 under an O2 atm., annulation of sulfoximine derivative (I) and PhCú·CPh gave 89% 1,2-benzothiazine (II).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cheng, Ying’s team published research in Chemistry – A European Journal in 2016 | CAS: 145026-07-9

Rhodium-Catalyzed ortho-Amidations in the Preparation of Thiadiazine 1-Oxides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Rhodium-catalyzed ortho-amidations of sulfoximines R1C6H4S(O)(=N)R2 (R1 = H, 4-Br, 5-CH3, etc.; R2 = CH3CH2, octyl, C6H5, etc.) lead to key intermediates for the preparation of thiadiazine 1-oxides I (R = H, 4-CH3, 4-Br, 4-C6H5, 3-NO2). Following a straightforward protocol, a variety of synthetically valuable compounds can be obtained, thus circumventing common multistep approaches towards potentially bioactive products.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tan, Mingchao’s team published research in Asian Journal of Organic Chemistry in 2019 | CAS: 145026-07-9

I2-Catalyzed Oxidative N-P Cross-Coupling of Diarylphosphine Oxides and Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

A new synthetic method for the synthesis of N-phosphinyl sulfoximines that proceeds by an I2-catalyzed oxidative N-P cross-coupling reaction has been developed. N-phosphinylated sulfoximines are synthesized from sulfoximines and diarylphosphine oxides using 10 mol% I2 as a catalyst, one equiv H2O2 as a green oxidant and PEG400 as a greener solvent. Chirality of S-methyl-S-phenylsulfoximine is retained in the coupling products (100% ee).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Thinh, B. B.’s team published research in Chemistry of Natural Compounds in 2022-07-31 | CAS: 483-76-1

Chemical composition and antioxidant activity of essential oil from fruit of Schisandra perulata. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Schisandra (Schisandraceae) grow in East Asia and number 30 species. They are rich sources of lignans and triterpenoids that are known to activate various useful biol. process. S. perulata Gagnep. is an endemic species of the genus Schisandra found in Vietnam. We analyzed the composition and antioxidant activity of essential oil obtained from fruit of S. perulata. Essential oils were collected,dried over anhydrous Na2SO4, and stored at 4¡ãC for further anal. Each extraction was performed in triplicate. The chem. compositions of essential oils from fruit of S. perulata were determined by gas chromatog. (GC)and GC-mass-spectrometry (GC-MS) using the published method . Anal. of GC-MS spectra of the essential oil detected 46 compounds making up 90.25% of the oil (Table 1). The essential oil was dominated by sesquiterpenes (76.90%). Oxygen-saturated sesquiterpenes, monoterpenes, and oxygen-saturated monoterpenes made up 4.94, 4.86, and 3.55%,resp. The main oil constituents were ¦Ä-cadinene (24.74%), ¦Á-ylangene (16.38), trans-¦Á-bergamotene (7.84), ¦Â-elemene(6.91), and ¦Â-himachalene (6.27). This is the first report on the chem. composition of essential oil from fruit of S. perulata.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem