Tag: M.W=200-250

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

Reactions of difluoroiodotoluene with NH-sulfoximines provide new hypervalent iodine(III) reagents, which photocatalytically transfer a fluoro and a sulfoximidoyl group onto styrenes with high regioselectivity [e.g., stepwise I + II followed by treatment with styrene and photocatalyst under blue LED ¡ú III (83%, diastereomer mix)]. The substrate scope is broad with respect to both sulfoximines and olefins. Following an operationally simple protocol, a large library of fluorine-containing N-functionalized sulfoximines can be accessed. Results from mechanistic investigations revealed the importance of radical intermediates.

Photocatalytic Fluoro Sulfoximidations of Styrenes. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

N-Benzylation of NH-sulfoximines via visible light photocatalysis is realized. Under mild reaction conditions, photocatalyst promotes the direct cross-coupling of NH-sulfoximines with benzyl bromides to form N-benzyl sulfoximines. Superbases which are usually used in reported coupling of NH-sulfoximines with alkyl halides were not needed. This method is also suitable for the synthesis of N-allyl sulfoximines.

Photocatalytic N-benzylation of NH-sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

The present investigation was aimed to assess the toxicity of Lavandula coronopifolia (Lamiaceae) essential oil (EO) against adult Mediterranean fruit fly. Ceratitis capitata (Wiedemann) (Diptera Tephritidae) is one of the most destructive fruit pests in Morocco. Essential oil was extracted from leaves of lavender (L. coronopifolia) by hydrodistillation and analyzed by GC and GC/MS. The main compound is carvacrol (48.9%) followed by E-caryophyllene (10.8%) and caryophyllene oxide (7.7%). The EO was examined in the laboratory for 7 days to assess their activity against Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) adults by ingestion toxicity. We also conducted oviposition bioassay in the laboratory, testing the oviposition deterrence of essential oils. The oil showed 75% mortality of adults at the concentration of 150¦Ìl/g after 24 h of exposure. Great differences in insect mortality were observed depending on the sex of the insects, oil concentrations and exposure time. The ingestion toxicity potential of L. coronopifolia on adults was higher (LC 50 = 86.34¦Ìl/g, LC 95 = 236.07¦Ìl/g) and also, deterred significantly the oviposition by C. capitata, reducing the number of eggs laid by about 94% compared with the controls for the concentration of 55¦Ìl/g. The results suggested that L. coronopifolia EOs may have potential as a control agent against this major stored product insect.

Evaluation of insecticidal activity of Lavandula coronopifolia essential oil against the Mediterranean fruit fly Ceratitis capitata Wiedemann. (Diptera: Tephritidae). Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

(2S)-2-Amino-4-(butylsulfonimidoyl)butanoic acid (BD136012) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 1621962-30-8.

Aluminum (Al), a neurotoxin agent, is universal in the earth crust, but its bioavailability and toxicity are manifested under acidic conditions. Up to 60% of the acid soils are distributed in tropical and subtropical regions, where crops simultaneously experience heat-shock stress. Here, we investigated the effects of heat shock-priming on Al tolerance in two different wheat genotypes. Conditioning of wheat seedlings with short period high temperature significantly alleviated Al-induced root growth inhibition, but did not significantly affect Al accumulation. However, we observed that heat shock-primed roots maintained lower levels of lipid peroxidation and higher cell viability. These priming-triggered effects were associated with reactive oxygen species (ROS) homeostasis. Furthermore, conditioning of plants with high temperature increased the contents of reduced ascorbate and glutathione, and ratios of reduced to oxidized forms of these mols. in wheat roots. However, ascorbate or glutathione biosynthesis inhibitors markedly prevented heat shock priming-induced ROS reduction accompanied by aggravated root elongation. Moreover, heat shock-priming enhanced the metabolic intensity of ascorbate-glutathione cycle, as activities of the cycle-allied enzymes were significantly increased. These results suggest that heat-shock induces cross adaptation to Al toxicity through sustaining efficient ascorbate-glutathione cycle operation in wheat plants.

Heat shock induces cross adaptation to aluminum stress through enhancing ascorbate-glutathione cycle in wheat seedlings. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

The variability of the chem. composition of the aerial part of common yarrow (Achillea millefolium L.) was studied as a function of its environmental growth conditions. Samples of four populations of A. millefolium growing wild at various altitudes (1150, 1500, 1700, and 2450 m) above sea level were collected. Their essential oils were obtained by hydrodistillation followed by a determination of their chem. compositions by chromatog.-mass-spectrometry. Anal. results showed that the yield of essential oil from the plants depended on the habitat and varied from 0.06 to 0.16 mL/100 g. The composition of the essential oil of A. millefolium comprised 61 constituents, of which 47 were identified, the main group being monoterpenes and their derivatives The yield of essential oil and its composition were controlled by linear effects of several abiotic factors related to the altitude gradient.

Variability of the Constituent Composition of Achillea millefolium Essential Oils in the Wild Flora of Dagestan. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

N-Alkynylated sulfoximines undergo acid-promoted cyclization processes under mild reaction conditions. The transformations proceed in short reaction times affording sulfoximidoyl-functionalized naphtho[2,1-b]thiophenes or pyrrolo[1,2-a]quinolines in up to excellent yields.

Exploring the Reactivity of N-Alkynylated Sulfoximines: Acid-Catalyzed Cyclizations. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

Treatment of NH-sulfoximines with pseudocyclic benziodoxole triflate results in N-I bond formation leading to a new type of sulfoximidoyl-containing hypervalent iodine(III) reagents in high yields. Degradation studies revealed a pronounced stability in both the solid state and in solution

Sulfoximidoyl-Containing Hypervalent Iodine(III) Reagents: 1-Sulfoximidoyl-1,2-benziodoxoles. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Reducing the postharvest loss of cereal grains caused by deleterious fungi is critically important for the grain supply chain. Exploring antifungal constituents of plant volatile organic compounds (PVOCs) could promote the development of natural gaseous fungicides in controlling the decay of postharvest grains. In this study, PVOCs were extracted from clove (Syzygium aromaticum L.) buds and the primary constituents thereof were investigated for their effect on Aspergillus flavus growth in media postharvest grains. Fumigation with clove buds volatiles effectively inhibited A. flavus proliferation in 20% moisture wheat grains under simulated storage conditions. Gas chromatog.-mass spectrometry anal. revealed that eugenol and caryophyllene were the two main constituents of clove bud volatiles (49.80% and 36.68%, resp.). An antifungal assay demonstrated that eugenol was responsible for the antifungal activity of clove bud volatiles against A. flavus. Eugenol can completely inhibit A. flavus growth at 0.12 and 0.40 ¦ÌL/mL in vapor phase fumigation and liquid contact, resp. The proliferation of A. flavus in 20% moisture wheat grains was completely controlled after fumigation with 600 ¦ÌL/L eugenol vapor. Eugenol treatment can damage the membrane integrity of A. flavus mycelia, resulting in increased intracellular electrolyte leakage. The 38 metabolites in A. flavus hyphae exposed to 0.40 ¦ÌL/mL eugenol were markedly differentially expressed and principally involved in the biosynthesis of glycerophospholipids, linoleic acid metabolism, fatty acid metabolism, sugar metabolism, and ATP-binding cassette transporters. Eugenol also causes phosphatidylserine eversion of the plasma membrane, increased reactive oxygen species, decreased ATP production, and damaged DNA in A. flavus. We propose that eugenol treatment can disrupt cell membrane integrity, fatty acid ¦Â-oxidation, and induce apoptosis in A. flavus. This study demonstrated the potential application of clove bud volatile organic compounds as biofumigants for postharvest grain management and provided new insights into the antifungal mechanism of the main constituents against A. flavus growth.

The effect of volatile compounds of Syzygium aromaticum flower buds against Aspergillus flavus growth on wheat grain at postharvest stage. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Selenium nanoparticles (Se-NPs) have different applications in various technologies due to their individual properties. In order to investigate the impacts of different concentrations of a green-synthesized selenium nano-complex (0, 20, 40, 60, and 80 mg L-1) on the chem. composition, antioxidant capacity and antimicrobial activity of lemongrass essential oil (EO), an experiment was designed as a completely randomized design (CRD) with four replications. The application of 40 mg L-1 selenium nano-complex caused the highest EO yield (3.96 ¡À 0.09%). The dominant compounds in EO, geranial (44.12 ¡À 1.22%) and neral (32.53 ¡À 1.08%), were achieved by the application of 60 mg L-1 selenium nano-complex. HPLC anal. indicated that the extracts were rich in 5-o-cafeoylquinic acid, luteolin 6-c-pentosyl-8-c-pentoside, and luteolin 2-o-deoxyhexosyl-6-c-glucoside. The extracts of lemongrass plants treated with 40 and 60 mg L-1 selenium nano-complex achieved the highest amount of 5-o-cafeoylquinic acid (25.29¡À1.31 and 24.16¡À1.26 ¦Ìg mL-1, resp.). The highest antioxidant capacity was observed in the 40 mg L-1 selenium nano-complex treated plants. The min. inhibitory concentration (MIC) of EO derived from the 60 mg L-1 selenium nano-complex treated lemongrass for Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Candida albicans was 0.63¡À0.03, 1.84¡À0.1, 1.05¡À0.05, 0.008¡À0.01, 0.6¡À0.01 and 0.1¡À0.01 mg mL-1, resp. It is expected that the selenium nano-complex would find a wide range of applications in medicine for its antioxidant and antimicrobial properties. It may also be applied to medicinal plants to enhance the quality and quantity of EOs.

Modifications in Lemongrass (Cymbopogon spp.) in response to green synthesized nano-selenium complex. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A mild and facile Cp*Rh(III)-catalyzed C-H activation and intramol. cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines I (R1 = H, 2-Me, 2-F, 4-Br, 3-OMe, (CH2)4, etc.; R2 = Me, Et, Ph, Bn, etc.; R3 = H, 10-Me,10-OMe, 11-Cl, 11-F, etc.) scaffolds using S-phenylsulfoximides R4C6H4S(O)(=NH)(R2) and 4-diazoisochroman-3-imine II (R5 = H, 7-Me, 6-OMe, 7-OMe, 6-Cl, etc.) as substrates under room temperature This method features diverse substituents and functional groups tolerance and relatively mild reaction conditions with moderate to excellent yields. Addnl., retentive configuration of sulfoximides in the conversion has been verified.

Sulfoximines-assisted Rh(III)-catalyzed C-H activation and intramolecular annulation for the synthesis of fused isochromeno-1,2-benzothiazines scaffolds under room temperature. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem