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Fusani, Pietro’s team published research in Industrial Crops and Products in 2022-11-01 | CAS: 483-76-1

Composition and biological activity of essential oils from Artemisia roxburghiana Besser and Elsholtzia fruticosa Rehder cultivated in Italy. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

The plants Artemisia roxburghiana Besser and Elsholtzia fruticosa Rehder were evaluated as innovative crops for the production of essential oils with valuable biol. activity. For both species, Clevenger distillation resulted in high essential oil contents of 1.08 and 1.79 mL¡¤100 g-1 dry weight for A. roxburghiana and E. fruticosa, resp. According to the results of GC/FID and GC/MS analyzes, the composition of essential oil of A. roxburghiana was characterized by cis-thujone (23.05%), 1,8-cineole (21.56%), and camphor (13.82%), while E. fruticosa oil was rich in 1,8-cineole (50.06%) and ¦Ã-terpinene (14.11%). The bioactivity of the oils of the two species was evaluated in vitro against both pathogenic Gram-pos. and Gram-neg. bacterial strains by disk diffusion assay and determination of the minimal inhibitory concentration They were also tested as natural insecticides by carrying out mortality and fecundity analyzes against the aphid Mizus persicae. E. fruticosa oil showed higher antibacterial activity compared to A. roxburghiana, particularly against Staphylococcus aureus (MIC 2.0 and 62.5 mg¡¤mL-1) and Escherichia coli (MIC 7.8 and 62.5 mg¡¤mL-1). Both plant species revealed high aphicidal activity against the polyphagous pest M. Persicae according to the nymph mortality and fecundity reduction, and their efficacy was comparable to that of azadyrachtin. This study shows the prospects of the two investigated species as possible innovative crops for the production of essential oils to be employed in agro-industry.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Deba-Rementeria, Shuyana’s team published research in International Journal of Food Science and Technology in 2022-08-31 | CAS: 483-76-1

Orange peel fermentation using Lactiplantibacillus plantarum: microbiological analysis and physico-chemical characterisation. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Summary : To find an innovative use for orange peels discarded in the orange juice-making process, a fermentative process was assessed using a Lactiplantibacillus plantarum strain. Blanched or rinsed peels were submerged in a 5% NaCl-3% inoculated sucrose brine for 10 days. Total soluble solids, pH, sugars and total aerobic and anaerobic counts were determined in the brines to characterize the process. The final products were characterised by instrumental texture, color and volatile composition The blanching pretreatment had a significant effect on the whole process and the final product characteristics. Anaerobic bacteria total counts were significantly higher in the blanched samples during the whole fermentation, and pH decreased significantly slower in these samples than in the rinsed ones. Rinsed samples were characterised by higher aerobic total counts, higher sucrose consumption and higher glucose, fructose and polyalcs. production The texture was softer in the pretreated samples, probably due to the blanching process rather than the fermentation The volatile composition was quite similar between samples, although it was different from one of the raw orange peels due to a significant decrease in various volatile compounds

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Miao, Jinmin’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2014 | CAS: 145026-07-9

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A novel rhodium-catalyzed imination of sulfoxides using O-(2,4-dinitrophenyl)hydroxylamine is developed under mild conditions with good functional group tolerance. This method provides an efficient access to free NH-sulfoximines, an important structural unit in a variety of biol. active compounds E.g., in presence of Rh2(esp)2 and O-(2,4-dinitrophenyl)hydroxylamine in trifluoroethanol, imination of sulfoxide derivative (I) gave 84% sulfoximine derivative (II).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mahanta, Bhaskar Protim’s team published research in Industrial Crops and Products in 2022-06-30 | CAS: 483-76-1

Phytotoxic essential oil from black turmeric (Curcuma caesia Roxb.) rhizome: Screening, efficacy, chemical basis, uptake and mode of transport. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Plant-based phytotoxins play an important role in plant-plant interaction and are of great promise for the development of bioherbicide. In this study, screening of essential oils from six different Curcuma rhizomes identified black turmeric (Curcuma caesia Roxb.) oil as an efficient growth inhibitor in wheatgrass coleoptile bioassay (IC50 57.1¦Ìg/mL). The phytotoxic efficacy of this oil was further confirmed through the dose dependent (10.0-300.0¦Ìg/mL) inhibition of germination, coleoptile and radicle growth of wheatgrass seeds in water medium (IC50 176.7, 90.6 and 93.0¦Ìg/mL resp.) and the pre-germinated seeds in agar medium. Activity-guided fractionation and purification of the crude oil identified curzerenone, a major furanosesquiterpene in this oil as the most active phytotoxin (IC50 13.0¦Ìg/mL in coleoptile bioassay; 188.3, 34.7 and 36.7¦Ìg/mL resp. in water medium). Structure-activity relationship study indicated the importance of all the functional groups for its phytotoxicity. A significant contribution by the oxygenated monoterpenes towards oil phytotoxicity was also evidenced. Though inhibitory efficacy of the oil was comparatively weak in soil, a profound activity through aerial diffusion was observed against germination and/or growth of fresh and pre-germinated wheatgrass seeds (IC50 1.4-6.2 mg/L air). The study also confirmed the uptake of active phytotoxins with no detectable transformation by the seeds in water and their persistence in the soil for at least one and half months. Further, its applicability was demonstrated through an efficient post-emergence growth inhibition (IC50 37.0-81.4¦Ìg/mL) of bermudagrass weed in water and agar medium.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Pintatum, Aknarin’s team published research in Arabian Journal of Chemistry in 2022-10-31 | CAS: 483-76-1

Volatile constituents of Amomum argyrophyllum Ridl. and Amomum dealbatum Roxb. and their antioxidant, tyrosinase inhibitory and cytotoxic activities. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The volatile components from fresh rhizomes and leaves of Amomum argyrophyllum Ridl. and Amomum dealbatum Roxb. were performed using HS-SPME and charac-terized by GC-MS. A total of 49, 47, 49, and 34 compounds were identified from the rhizomes and leaves of A. argyrophyllum and A. dealbatum, resp. The major components were ¦Â-pinene, ¦Á-pinene, and o-cymene. The rhizome extracts exhibited total phenolic content of 2.9 ¡À 0.5 and 2.1 ¡À 0.6 mg gallic acid equivalent The IC50 values of DPPH and ABTS were 179.8 ¡À 3.9 ¦Ìg/mL, 392.9 ¡À 2.6 ¦Ìg/mL, 120.3 ¡À 2.5 ¦Ìg/mL, and 328.6 ¡À 3.3 ¦Ìg/mL, resp. The FRAP values were 76.5 ¡À 7.8 and 84.9 ¡À 4.4 ¦ÌM ascorbic acid equivalent The extracts showed weak antibacterial activity and tyrosinase inhibitory activity of 69.0 ¡À 3.6 and 53.7 ¡À 7.4 mg kojic acid equivalent The cytotoxicity effect was assessed with the MTT assay at 200 ¦Ìg/mL. The extracts showed no toxicity. In addition, the anti-inflammatory properties of extracts were evaluated, and showed potential to inhibit nuclear factor-¦ÊB (NF-¦ÊB) activity.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Aher, Yogesh N.’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2018 | CAS: 145026-07-9

Cp*Ir(III)-catalyzed C-H/N-H functionalization of sulfoximines for the synthesis of 1,2-benzothiazines at room temperature. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

The first Cp*Ir(III)-catalyzed C-H/N-H bond functionalization of sulfoximines with ¦Á-diazocarbonyl compounds has been developed for the synthesis of 1,2-benzothiazines under redox-neutral conditions. The reactions proceed at room temperature with excellent functional group tolerance and high yields without the requirement of any silver additive.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Jeldi, Lamya’s team published research in South African Journal of Botany in 2022-07-31 | CAS: 483-76-1

Chemical composition, antifungal and antioxidant activities of wild and cultivated Origanum compactum essential oils from the municipality of Chaoun, Morocco. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Origanum compactum is a medicinal species endemic to Morocco and highly exploited for its therapeutic properties. In the present study, we examined the chem. composition and biol. activities of the essential oils from wild and cultivated O. compactum. The chem. composition was analyzed by gas chromatog. coupled with mass spectrometry (GC/MS). The yield of essential oils was 3.5% for the wild plants and 3.4% for the cultivated plants. Twelve compounds have been identified in the essential oils of wild plants. Carvacrol was the predominant compound (59.0%), followed by p-cymene (18.4%) and then by ¦Ã-terpinene (8.4%). For the cultivated plants, 27 compounds were identified. Here again, carvacrol was the predominant compound (45.3%), followed by p-cymene (22.2%) and by ¦Ã-terpinene (10.1%). The antifungal activity of essential oils was evaluated against four Candida strains using the aromatogram method, the min. inhibitory concentration (MIC) and the min. fungicidal concentration (MFC). In semi-solid medium, essential oils were active against all the strains tested. In liquid medium, MIC values ranged from 216 to 234¦Ìg/mL, while the MFC was 288¦Ìg/mL. Antioxidant activity was investigated by 2,2-diphenyl-1,1,picrylhydrazil radical (DPPH) and the findings showed that the essential oils of both plants have a good antioxidant effect. In conclusion, domestication is a practical approach to preserve O. compactum from extinction without compromising its biol. activities. Besides, the essential oils of O. compactum could be a promising and sustainable alternative to replace the synthetic compounds used currently in pharmaceutical and food industries.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Dong, Ziliang’s team published research in Chem in 2020-06-11 | CAS: 83730-53-4

Corrigendum: Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress [Erratum to document cited in CA173:313754]. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

(2S)-2-Amino-4-(butylsulfonimidoyl)butanoic acid (BD136012) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 1621962-30-8.

In the originally published version of this article, the confocal images of 4T1 cells from the PBS group in Figure 3C were unfortunately identical to those in the BSO group as a result of a copy-and-paste error during figure compilation. The corrections are provided.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Guan, Xin’s team published research in Advanced Functional Materials in 2020-07-06 | CAS: 83730-53-4

Tumor Metabolism-Engineered Composite Nanoplatforms Potentiate Sonodynamic Therapy via Reshaping Tumor Microenvironment and Facilitating Electron-Hole Pairs’ Separation. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Reactive oxygen species (ROS) depletion and low ROS production that result from the intratumoral redox metabolism equilibrium and low energy conversion efficiency from ultrasound mech. energy to ROS-represented chem. energy, resp., are two vital inhibitory factors of sonodynamic therapy (SDT). To address the two concerns, a tumor metabolism-engineered composite nanoplatform capable of intervening intratumoral ROS metabolism, breaking the redox equilibrium, and reshaping the tumor microenvironment is constructed to reinforce SDT against tumors. In this metabolism-engineered nanoplatform, Nb2C nanosheets serve as the scaffold to accommodate TiO2 sonosensitizers and L-buthionine-sulfoximine. Systematic experiments show that such nanoplatforms can reduce ROS depletion via suppressing glutathione synthesis and simultaneously improving ROS production via the Nb2C-enhanced production and separation of electron-hole pairs. Contributed by the combined effect, net ROS content can be significantly elevated, which results in the highly efficient anti-tumor outcomes in vivo and in vitro. Moreover, the combined design principles, i.e., tumor metabolism modulation for reducing ROS depletion and electron-hole pair separation for facilitating ROS production, can be extended to other ROS-dependent therapeutic systems.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shahrivari, Saba’s team published research in Scientific Reports in 2022-12-31 | CAS: 483-76-1

A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Artemisia is one of the most diverse genera in the Asteraceae family. The genus is wildly distributed in Irano-Turanian habitats and includes 34 species in Iran. Here, for the first time the essential oil variability, antioxidants and anti-cholinesterase and anti-tyrosinase activities of extracts of three Artemisia species (A. tournefortiana, A. khorassanica, A. haussknechtii), from different regions of Iran were evaluated. Based on GC-MS analyses, 81.84% to 98.70% of the total oils were identified. Cluster anal. grouped the studied populations in three different chemotypes. The highest and the lowest essential oil contents were observed in A. khorassanica and A. haussknechtii species, resp. Camphor, en-in-dicycloether, 1,8-cineole and (Z)-¦Â-farnesene were the dominant components of essential oil in investigated ecotypes. The results revealed that the total phenol content was higher in A. tournefortiana collected from Kerman and A. haussknechtii collected from Chaharmahal and Bakhtiari. However, the lowest phenol content was recorded for A. haussknechtii collected from Isfahan province. The highest flavonoids content was found in A. tournefortiana collected from West Azerbaijan and A. khorassanica collected from North Khorasan. The highest FRAP antioxidant activity was observed in A. tournefortiana (Kerman) and the lower amount was in A. haussknechtii collected from Kohgiluyeh and Boyer-Ahmad. The highest antioxidant activity by DPPH method was in A. khorassanica collected from South Khorasan and the lowest activity was in Isfahan’s A. haussknechtii. The acetycholine esterase inhibitory activity was higher in A. tournefortiana collected from West Azerbaijan; and the lowest activity was in A. haussknechtii collected from Chaharmahal and Bakhtiari province. The highest tyrosinase inhibitory activity was in A. khorassanica collected from North Khorasan; and the lowest was in A. haussknechtii collected from Chaharmahal and Bakhtiari.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem