Tag: M.W:200-300

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0 ) is researched.Recommanded Product: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane.Rivilla, Ivan; Aparicio, Borja; Bueno, Juan M.; Casanova, David; Tonnele, Claire; Freixa, Zoraida; Herrero, Pablo; Rogero, Celia; Miranda, Jose I.; Martinez-Ojeda, Rosa M.; Monrabal, Francesc; Olave, Benat; Schafer, Thomas; Artal, Pablo; Nygren, David; Cossio, Fernando P.; Gomez-Cadenas, Juan J. published the article 《Fluorescent bicolor sensor for low-background neutrinoless double β decay experiments》 about this compound( cas:33941-15-0 ) in Nature (London, United Kingdom). Keywords: high pressure xenon gas detector barium tagging neutrinoless decay; fluorescent bicolor sensor neutrinoless double beta decay experiment. Let’s learn more about this compound (cas:33941-15-0).

Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is expected to be at least ten orders of magnitude greater than the typical lifetimes of natural radioactive chains, which can mimic the exptl. signature of neutrinoless double β decay. The most robust identification of neutrinoless double β decay requires the definition of a signature signal-such as the observation of the daughter atom in the decay-that cannot be generated by radioactive backgrounds, as well as excellent energy resolution In particular, the neutrinoless double β decay of 136Xe could be established by detecting the daughter atom, 136Ba2+, in its doubly ionized state. Here, the authors demonstrate an important step towards a ′barium-tagging′ experiment, which identifies double β decay through the detection of a single Ba2+ ion. they propose a fluorescent bicolor indicator as the core of a sensor that can detect single Ba2+ ions in a high-pressure xenon gas detector. In a sensor made of a monolayer of such indicators, the Ba2+ dication would be captured by one of the mols. and generate a Ba2+-coordinated species with distinct photophys. properties. The presence of such a single Ba2+-coordinated indicator would be revealed by its response to repeated interrogation with a laser system, enabling the development of a sensor able to detect single Ba2+ ions in high-pressure xenon gas detectors for barium-tagging experiments

Although many compounds look similar to this compound(33941-15-0)Recommanded Product: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, numerous studies have shown that this compound(SMILES:O1CCOCCOCCOCCOCCNCC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 481054-89-1, is researched, Molecular C12H10BrNO2, about Polythiophene-Encapsulated Bimetallic Au-Fe3O4 Nano-Hybrid Materials: A Potential Tandem Photocatalytic System for Nondirected C(sp2)-H Activation for the Synthesis of Quinoline Carboxylates, the main research direction is polythiophene encapsulated bimetallic gold Fe3O4 photocatalysis quinoline carboxylate preparation.Application In Synthesis of Ethyl 6-bromoquinoline-3-carboxylate.

Hetero-oligophenylene derivative 3 appended with thiophene moieties was designed and synthesized which undergoes aggregation to form J-type fluorescent aggregates in H2O/THF (7/3) media. These aggregates served as reactors for the preparation of bimetallic Au-Fe3O4 NPs. During the reduction process, aggregates of derivative 3 were oxidized to the polythiophene species 4. Interestingly, the polythiophene species 4, having a fibrous morphol., served as a shape- and morphol.-directed template for assembly of bimetallic Au-Fe3O4 NPs in a flower-like arrangement. Furthermore, polythiophene-encapsulated bimetallic 4:Au-Fe3O4 nanohybrid materials served as an efficient and recyclable catalytic system for C(sp2)-H bond activation of unprotected electron-rich anilines for the construction of synthetically versatile quinoline carboxylates via C-H activation, carbonylation, and subsequent annulation under mild and eco-friendly conditions (aqueous media, room temperature, visible-light irradiation, and aerial conditions).

Although many compounds look similar to this compound(481054-89-1)Application In Synthesis of Ethyl 6-bromoquinoline-3-carboxylate, numerous studies have shown that this compound(SMILES:O=C(C1=CC2=CC(Br)=CC=C2N=C1)OCC), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 96651-85-3, is researched, Molecular C13H18ClN, about Spiropiperidines as high-affinity, selective σ ligands., the main research direction is spiropiperidine selective sigma ligand; tetralin spiropiperidino selective sigma ligand; indan spiropiperidino selective sigma ligand; benzocycloheptane spiropiperidino selective sigma ligand; radioligand displacement spiropiperidinobenzocycloalkane; structure activity spiropiperidinobenzocycloalkane receptor binding.Related Products of 96651-85-3.

A variety of achiral conformationally restricted spirocyclic piperidines were prepared in an attempt to investigate the functional role of the central σ recognition site. All compounds possessed a lipophilic N-substituent incorporating either a tetralin (I; n = 2, R = PhCH2, Bu, hexyl, 2-picolyl, cyclohexylmethyl, CH2CH:CH2, 2-furylmethyl, 2-thienylmethyl, CH2CH:CMe2, etc.), indan (I; n = 1, R = PhCH2, PhCH2CH2, CH2CH:CMe2, Bu, etc.), or benzocycloheptane skeleton (I; n = 3, R = PhCH2, Bu). Their in vitro affinity at the σ site was assessed in radioligand displacement experiments with guinea pig cerebellum homogenates using the σ-specific radioligand N,N-di-o-[5-3H]-tolylguanidine (II). A study of the structure-activity relationships identified the N-Bu and N-dimethylallyl substituents as the optimum groups for high affinity and selectivity at the σ site, e.g., I (n = 1, R = CH2CH:CMe2), pIC50 = 8.9 vs II and >10,000-fold selective over the dopamine D2 receptor. Such compounds are amongst the highest affinity σ ligands reported to date, with excellent selectivity over the dopamine D2 receptor, and may serve as a useful tool for exploring the physiol. role of the σ site.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Mechanochemical Solvent-Free Conditions for the Synthesis of Pillar[5]arene-Containing [2]Rotaxanes, published in 2019, which mentions a compound: 33941-15-0, mainly applied to pillararene diamide rotaxane inclusion preparation mechanochem ball milling, COA of Formula: C12H25NO5.

Pillar[5]arene-containing [2]rotaxanes have been efficiently prepared under solvent-free conditions. Specifically, solid-to-solid ball-milling of primary or secondary amine reagents with the inclusion complex resulting from the association of dodecanedioyl dichloride and a pillar[5]arene derivative provided the corresponding diamide [2]rotaxanes in good to excellent yields. Importantly, [2]rotaxanes difficult or even impossible to prepare under classical reaction conditions in solution, are now easily obtained.

In some applications, this compound(33941-15-0)COA of Formula: C12H25NO5 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Application of 33941-15-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, is researched, Molecular C12H25NO5, CAS is 33941-15-0, about Axially- and Meso-Substituted Aza-Crown-Ether-Incorporated BIII Subporphyrins: Control of Electron-Donating Ability by Metal Ion Chelation.

A series of subporphyrin-based fluorescent probes bearing 1-aza-15-crown-5 or 1-aza-18-crown-6 moieties at the meso or axial positions were prepared by Pd-catalyzed Buchwald-Hartwig amination reaction of the corresponding bromosubporphyrins. Both types of aza-crown-ether-incorporated subporphyrins were fluorescent in solution and exhibited cation-dependent absorption and fluorescence changes. In fluorescence titration experiments, opposite responses were observed for the two types of subporphyrins. Namely, fluorescence quenching occurred for the meso-substituted subporphyrins while fluorescence enhancement was observed for the axially-substituted subporphyrins. These results demonstrate the advantage of subporphyrins being viable to serve as turn-off-type or turn-on-type fluorescence probes, depending upon substitution pattern.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Recommanded Product: 33941-15-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, is researched, Molecular C12H25NO5, CAS is 33941-15-0, about Facile fabrication of crown ether functionalized lignin-based biosorbent for the selective removal of Pb(II). Author is Jin, Can; Liu, Guifeng; Wu, Guomin; Huo, Shuping; Liu, Zengshe; Kong, Zhenwu.

A novel 1-Aza-18-crown-6 functionalized lignin-based adsorbent (AFL) is facilely prepared through Mannich reaction in a one-step process. Structure characterization by Fourier transform IR spectroscopy, NMR spectroscopy, elemental anal. and XPS confirmed the successful fabrication of AFL. AFL was observed to display enhanced adsorption capacity (Qmax = 91.4 mg/g) and superior selectivity toward Pb(II) ions, due to a display of crown ether units and their interaction with metal ions. The adsorption equilibrium results from a kinetic study indicated that the Pb(II) adsorption by AFL was a chemisorption process. Addnl., the obtained thermodn. parameters showed the adsorption mechanism to be an exothermic and spontaneous process at room temperature The AFL could be regenerated by desorption of Pb(II) ions and remained at over 80% adsorption efficiency after four adsorption-desorption cycles. Therefore, the AFL displays acceptable adsorption performance and can serve as a bioresource-based and recyclable adsorbent material, portending a new expectation in the application for water purification engineering.

In addition to the literature in the link below, there is a lot of literature about this compound(1,4,7,10,13-Pentaoxa-16-azacyclooctadecane)Recommanded Product: 33941-15-0, illustrating the importance and wide applicability of this compound(33941-15-0).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A One-Step Synthesis of 2,4-Unsubstituted Quinoline-3-carboxylic Acid Esters from o-Nitrobenzaldehydes, published in 2010-05-21, which mentions a compound: 481054-89-1, mainly applied to nitrobenzaldehyde diethoxypropionic acid ester modified reductive Friedlaender reaction tin; quinolinecarboxylic acid ester preparation; tin chloride modified reductive Friedlaender reaction mediator, COA of Formula: C12H10BrNO2.

A straightforward and efficient one-step procedure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid Et esters, e.g., I (R1 = Me, Et; R2 = H, F, Cl, Br, OH), is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inexpensive, com. available 3,3-diethoxypropionic acid Et ester and SnCl2·2H2O in refluxing ethanol.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl 6-bromoquinoline-3-carboxylate)COA of Formula: C12H10BrNO2, illustrating the importance and wide applicability of this compound(481054-89-1).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Shengran; Lin, Lin; Wang, Wenliang; Yan, Xinxin; Chen, Binggang; Jiang, Sangni; Liu, Sanrong; Ma, Xiaojing; Tian, Huayu; Yu, Xifei researched the compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0 ).Related Products of 33941-15-0.They published the article 《Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery》 about this compound( cas:33941-15-0 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: aza crown ether locked polyethyleneimine gene transfection. We’ll tell you more about this compound (cas:33941-15-0).

We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Rahman, Akib Bin; Okamoto, Hirokazu; Miyazawa, Yuya; Aoki, Shin researched the compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0 ).COA of Formula: C12H25NO5.They published the article 《Design and Synthesis of Supramolecular Phosphatases Formed from a Bis(Zn2+-Cyclen) Complex, Barbital-Crown-K+ Conjugate and Cu2+ for the Catalytic Hydrolysis of Phosphate Monoester》 about this compound( cas:33941-15-0 ) in European Journal of Inorganic Chemistry. Keywords: alk zinc copper cyclen barbital crown complex preparation; hydrolysis catalyst alk zinc copper cyclen barbital crown complex; DFT alk zinc copper cyclen barbital crown complex. We’ll tell you more about this compound (cas:33941-15-0).

The development of artificial mimics of natural enzymes such as hydrolases and phosphatases is one of the great challenges in bioorganic and bioinorganic chem. and related sciences. Supramol. strategies are one of the useful methods to construct artificial catalysts as mimics of natural enzymes and to understand their reaction mechanisms. Herein, the authors report on the formation of amphiphilic supramol. phosphatases by the 2 : 2 : 2 self-assembly of a bis(Zn2+-cyclen) complex (cyclen = 1,4,7,10-teraazacyclododecane) containing a 2,2′-bipyridyl (bpy) linker and one long alkyl chain (Zn2L3), 5,5-diethylbarbituric acid (Bar) derivative functionalized with 1-aza-18-crown-6 ether and Cu2+ in a two-phase solvent system (CHCl3/H2O). The authors hypothesized that crown ether moiety of the Bar-crown ether conjugate would form complexes with alk. ions and other metal ions such as Li+, Na+, K+, Rb+, Mg2+ and La3+ in organic phase to mimic the Mg2+ found as the third metal ion in the active site of alk. phosphatase (AP). The 2 : 2 : 2 : 4 complexes of Zn2L3, a Bar block equipped with the 18-crown-6 ether, Cu2+ and alk. metal are constructed in a two-phase solvent system. The resulting complexes have a higher hydrolysis activity for mono(4-nitrophenyl)phosphate (MNP) in the presence of K+ than that in the presence of Li+, Na+, Rb+, Mg2+ and La3+ and a greater hydrolysis activity than the authors′ previous supermols. having no crown ether part, suggesting that crown ether-K+ complex located in close proximity to the Cu2(μ-OH)2 core contributes to the acceleration of the MNP hydrolysis.

I hope my short article helps more people learn about this compound(1,4,7,10,13-Pentaoxa-16-azacyclooctadecane)COA of Formula: C12H25NO5. Apart from the compound(33941-15-0), you can read my other articles to know other related compounds.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Efange, Simon M. N.; Kamath, Ashok P.; Khare, Anil B.; Kung, Mei-Ping; Mach, Robert H.; Parsons, Stanley M. researched the compound: 2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride( cas:96651-85-3 ).Application of 96651-85-3.They published the article 《N-Hydroxyalkyl Derivatives of 3β-Phenyltropane and 1-Methylspiro[1H-indoline-3,4′-piperidine]: Vesamicol Analogs with Affinity for Monoamine Transporters》 about this compound( cas:96651-85-3 ) in Journal of Medicinal Chemistry. Keywords: monoamine transporter phenyltropane derivative preparation structure; methylspiro indolinepiperidine preparation monoamine transporter structure. We’ll tell you more about this compound (cas:96651-85-3).

As part of our ongoing structure-activity studies of the vesicular acetylcholine transporter ligand 2-(4-phenylpiperidino)cyclohexanol (vesamicol), N-hydroxy(phenyl)alkyl derivatives of 3β-phenyltropane, and 1-methylspiro[1H-indoline-3,4′-piperidine] were synthesized and tested for binding in vitro. Although a few compounds displayed moderately high affinity for the vesicular acetylcholine transporter, no compound was more potent than the prototypical vesicular acetylcholine transporter ligand vesamicol. However, a few compounds displayed higher affinity for the dopamine transporter than cocaine. We conclude that modification of the piperidyl fragment of vesamicol will not lead to more potent vesicular acetylcholine transporter ligands.

I hope my short article helps more people learn about this compound(2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride)Application of 96651-85-3. Apart from the compound(96651-85-3), you can read my other articles to know other related compounds.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem