Tag: M.W:200-300

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of quinolines from the Baylis-Hillman acetates via the oxidative cyclization of sulfonamidyl radical as the key step, published in 2002-08-26, which mentions a compound: 481054-89-1, mainly applied to quinolinecarboxylate preparation oxidative cyclization, Recommanded Product: 481054-89-1.

Et 3-quinolinecarboxylates I were synthesized in good to moderate yields from the Baylis-Hillman acetates II via the oxidative cyclization reaction of the N-tosylamidyl radical, which was generated from the rearranged tosylamide derivatives III by iodobenzene diacetate and iodine.

From this literature《Synthesis of quinolines from the Baylis-Hillman acetates via the oxidative cyclization of sulfonamidyl radical as the key step》,we know some information about this compound(481054-89-1)Recommanded Product: 481054-89-1, but this is not all information, there are many literatures related to this compound(481054-89-1).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane(SMILESS: O1CCOCCOCCOCCOCCNCC1,cas:33941-15-0) is researched.Application of 36620-11-8. The article 《Alkali metal cation effects on electrocatalytic CO2 reduction with iron porphyrins》 in relation to this compound, is published in Chinese Journal of Catalysis. Let’s take a look at the latest research on this compound (cas:33941-15-0).

The electrocatalytic CO2 reduction reaction (CO2RR) has attracted increasing attention in recent years. Practical electrocatalysis of CO2RR must be carried out in aqueous solutions containing electrolytes of alkali metal cations such as sodium and potassium. Although considerable efforts have been made to design efficient electrocatalysts for CO2RR and to investigate the structure-activity relationships using mol. model complexes, only a few studies have been investigated the effect of alkali metal cations on electrocatalytic CO2RR. In this study, we report the effect of alkali metal cations (Na+ and K+) on electrocatalytic CO2RR with Fe porphyrins. By running CO2RR electrocatalysis in DMF (DMF), we found that the addition of Na+ or K+ considerably improves the catalytic activity of Fe chloride tetrakis(3,4,5-trimethoxyphenyl)porphyrin (FeP). Based on this result, we synthesized an Fe porphyrin N18C6-FeP bearing a tethered 1-aza-18-crown-6-ether (N18C6) group at the second coordination sphere of the Fe site. We showed that with the tethered N18C6 to bind Na+ or K+, N18C6-FeP is more active than FeP for electrocatalytic CO2RR. This work demonstrates the pos. effect of alkali metal cations to improve CO2RR electrocatalysis, which is valuable for the rational design of new efficient catalysts.

From this literature《Alkali metal cation effects on electrocatalytic CO2 reduction with iron porphyrins》,we know some information about this compound(33941-15-0)Application of 33941-15-0, but this is not all information, there are many literatures related to this compound(33941-15-0).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Thapa, P.; Arnquist, I.; Byrnes, N.; Denisenko, A. A.; Foss, Jr. F. W.; Jones, B. J. P.; McDonald, A. D.; Nygren, D. R.; Woodruff, K. researched the compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0 ).Product Details of 33941-15-0.They published the article 《Barium Chemosensors with Dry-Phase Fluorescence for Neutrinoless Double Beta Decay》 about this compound( cas:33941-15-0 ) in Scientific Reports. Keywords: barium chemosensor phase fluorescence neutrinoless double beta decay. We’ll tell you more about this compound (cas:33941-15-0).

The nature of the neutrino is one of the major open questions in exptl. nuclear and particle physics. The most sensitive known method to establish the Majorana nature of the neutrino is detection of the ultra-rare process of neutrinoless double beta decay. However, identification of one or a handful of decay events within a large mass of candidate isotope, without obfuscation by backgrounds is a formidable exptl. challenge. One hypothetical method for achieving ultra- low-background neutrinoless double beta decay sensitivity is the detection of single 136Ba ions produced in the decay of 136Xe (“”barium tagging””). To implement such a method, a single-ion-sensitive barium detector must be developed and demonstrated in bulk liquid or dry gaseous xenon. This paper reports on the development of two families of dry-phase barium chemosensor mols. for use in high pressure xenon gas detectors, synthesized specifically for this purpose. One particularly promising candidate, an anthracene substituted aza-18-crown-6 ether, is shown to respond in the dry phase with almost no intrinsic background from the unchelated state, and to be amenable to barium sensing through fluorescence microscopy. This interdisciplinary advance, paired with earlier work demonstrating sensitivity to single barium ions in solution, opens a new path toward single ion detection in high pressure xenon gas.

When you point to this article, it is believed that you are also very interested in this compound(33941-15-0)Product Details of 33941-15-0 and due to space limitations, I can only present the most important information.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Thapa, Pawan; Byrnes, Nicholas K.; Denisenko, Alena A.; Mao, James X.; McDonald, Austin D.; Newhouse, Charleston A.; Vuong, Thanh T.; Woodruff, Katherine; Nam, Kwangho; Nygren, David R.; Jones, Benjamin J. P.; Foss, Frank W. Jr. published an article about the compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0,SMILESS:O1CCOCCOCCOCCOCCNCC1 ).Recommanded Product: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:33941-15-0) through the article.

Single-mol. fluorescence imaging (SMFI) of gas-phase ions has been proposed for “”barium tagging,”” a burgeoning area of research in particle physics to detect individual barium daughter ions. This has potential to significantly enhance the sensitivity of searches for neutrinoless double-beta decay (0νββ) that is obscured by background radiation events. The chem. required to make such sensitive detection of Ba2+ by SMFI in dry Xe gas at solid interfaces has implications for solid-phase detection methods but has not been demonstrated. Here, we synthesized simple, robust, and effective Ba2+-selective chemosensors capable of function within ultrapure high-pressure 136Xe gas. Turn-on fluorescent naphthalimide-(di)azacrown ether chemosensors were Ba2+-selective and achieved SMFI in a polyacrylamide matrix. Fluorescence and NMR experiments supported a photoinduced electron transfer mechanism for turn-on sensing. Ba2+ selectivity was achieved with computational calculations correctly predicting the fluorescence responses of sensors to barium, mercury, and potassium ions. With these mols., dry-phase single-Ba2+ ion imaging with turn-on fluorescence was realized using an oil-free microscopy technique for the first time-a significant advance toward single-Ba2+ ion detection within large volumes of 136Xe, plausibly enabling a background-independent technique to search for the hypothetical process of 0νββ.

When you point to this article, it is believed that you are also very interested in this compound(33941-15-0)Recommanded Product: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane and due to space limitations, I can only present the most important information.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 33941-15-0, is researched, Molecular C12H25NO5, about Red-Emitting Fluorescence Sensors for Metal Cations: The Role of Counteranions and Sensing of SCN- in Biological Materials, the main research direction is fluorescence sensor thiocyanate; aza-crown; counteranion; fluorescence; intramolecular-charge transfer; phthalocyanine.Related Products of 33941-15-0.

The spatiotemporal sensing of specific cationic and anionic species is crucial for understanding the processes occurring in living systems. Herein, the authors developed new fluorescence sensors derived from tetrapyrazinoporphyrazines (TPyzPzs) with a recognition moiety that consists of an aza-crown and supporting substituents. Their sensitivity and selectivity were compared by fluorescence titration experiments with the properties of known TPyzPzs (with either one aza-crown moiety or two of these moieties in a tweezer arrangement). Method of standard addition was employed for analyte quantification in saliva. For K+ recognition, the new derivatives had comparable or larger association constants with larger fluorescence enhancement factors compared to that with one aza-crown. Their fluorescence quantum yields in the ON state were 18× higher than that of TPyzPzs with a tweezer arrangement. Importantly, the sensitivity toward cations was strongly dependent on counteranions and increased as follows: NO3- < Br- < CF3SO3- < ClO4- ≪ SCN-. This trend resembles the chaotropic ability expressed by the Hofmeister series. The high selectivity toward KSCN was explained by synergic association of both K+ and SCN- with TPyzPz sensors. The sensing of SCN- was further exploited in a proof of concept study to quantify SCN- levels in the saliva of a smoker and to demonstrate the sensing ability of TPyzPzs under in vitro conditions. This literature about this compound(33941-15-0)Related Products of 33941-15-0has given us a lot of inspiration, and I hope that the research on this compound(1,4,7,10,13-Pentaoxa-16-azacyclooctadecane) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Quality Control of 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, is researched, Molecular C12H25NO5, CAS is 33941-15-0, about Towards a background-free neutrinoless double beta decay experiment based on a fluorescent bicolor sensor.

Neutrinoless double beta decay (ββ0v) is a putative nuclear decay that can occur if, and only if, neutrinos are their own antiparticles. Due to the smallness of neutrino masses, the lifetime of ββ0v is expected to be larger than 1 × 1026 yr, and the tiny expected signals are deeply buried in backgrounds associated with the natural radioactive chains, whose characteristic lifetime is sixteen orders of magnitude faster. Since no known background processes converts xenon to barium, detection of the daughter ion in candidate decay events effectively eliminates backgrounds. It has been recently proposed that a xenon gas time projection chamber could unambiguously tag the ββ0v decay 136Xe → Ba2+ + 2e-(+2v) by detecting the resulting Ba2+ ion in a single-atom sensor made of a monolayer of mol. indicators. The Ba2+ would be captured by one of the mols. in the sensor, and the presence of the single chelated indicator would be subsequently revealed by a strong fluorescent response from repeated interrogation with a suitable laser system. Here we describe a fluorescent bicolor indicator that binds strongly to Ba2+ and shines very brightly, shifting its emission color from green to blue when chelated in dry medium, thus providing a discrimination factor with respect to the unchelated species in excess of 104.

As far as I know, this compound(33941-15-0)Quality Control of 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, is researched, Molecular C12H25NO5, CAS is 33941-15-0, about Switching Dual Catalysis without Molecular Switch: Using A Multicomponent Information System for Reversible Reconfiguration of Catalytic Machinery, the main research direction is copper zinc terpyridine porphyrinato complex catalyst preparation kinetics.Application In Synthesis of 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane.

Different from the current paradigms of chem., a switchable catalytic system is presented that does not rely on a mol. switch in different toggling states but on a smart seven-component mixture that manages the reversible ON/OFF regulation of two catalytic processes. Hereunto, the workflow of two multicomponent rotary catalytic machineries was interlinked by the simultaneous shuffling of two components (metal and ligand) requiring perfect signaling in a 13-component system (see Movie 1). This network underwent reversible switching over three cycles as demonstrated by 1H NMR, UV-visible, and fluorescence spectroscopies and electrospray ionization mass spectrometry. Addition and removal of zinc(II) ions trigger three distinct events in parallel: the (i) mutually dependent self-assembly of three-component nanorotors and two-component reservoirs by resorting components, (ii) toggling between vastly different rotational exchange rates in the self-assembled rotors that directly affect catalysis, and (iii) toggling between two diverse catalytic reactions in a fully reproducible manner. Because of this information system, the concentrations of free aza-crown ether 7 and its complex with copper(I), i.e., [Cu(7)]+, which represent the effective catalysts, are up- and downregulated in a manner to alternately switch ON/OFF a catalytic conjugate addition and a click reaction.

From this literature《Switching Dual Catalysis without Molecular Switch: Using A Multicomponent Information System for Reversible Reconfiguration of Catalytic Machinery》,we know some information about this compound(33941-15-0)Application In Synthesis of 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, but this is not all information, there are many literatures related to this compound(33941-15-0).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane(SMILESS: O1CCOCCOCCOCCOCCNCC1,cas:33941-15-0) is researched.Formula: C11H9N. The article 《Selective Phase Transfer Reagents (OxP-crowns) for Chromogenic Detection of Nitrates Especially Ammonium Nitrate》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:33941-15-0).

Nitrogen and phosphorus-containing ions such as ammonium, nitrates and phosphates are anthropogenic pollutants while ammonium nitrate may be diverted for nefarious purposes in improvised explosive devices. Crown ether-oxoporphyrinogen conjugates (OxP-crowns) are used to selectively detect nitrates, especially their ion pairs with K+ and NH4+, based on ion pair complexation of OxP-crowns under phase transfer conditions. The presence of phosphate and carbonate lead to deprotonation of OxP-crowns. OxP-1N18C6 is capable of extracting ion pairs with nitrate from aqueous phase leading to a selective chromogenic response. Deprotonation of the OxP moiety leads to [OxP-]-1N18C6[K+] and is promoted by crown ether selective cation binding coupled with hydration of basic oxoanions, which are constrained to remain in the aqueous phase. This work illustrates the utility of mol. design to exploit partitioning and ion hydration effects establishing the selectivity of the chromogenic response.

Here is a brief introduction to this compound(33941-15-0)Reference of 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, if you want to know about other compounds related to this compound(33941-15-0), you can read my other articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reference of (1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid, is researched, Molecular C13H15BFNO4, CAS is 1000068-26-7, about Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists. Author is Bakir, Farid; Kher, Sunil; Pannala, Madhavi; Wilson, Norma; Nguyen, Trang; Sircar, Ila; Takedomi, Kei; Fukushima, Chiaki; Zapf, James; Xu, Kui; Zhang, Shao-Hui; Liu, Juping; Morera, Lisa; Schneider, Lisa; Sakurai, Naoki; Jack, Rick; Cheng, Jie-Fei.

A structurally novel liver X receptor (LXR) agonist (I) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. I increased ABCA1 gene expression by eightfold and SREBP1c by threefold in differentiated THP-1 macrophage cell lines. Confirmation of its agonistic activity against LXR was obtained in the co-factor recruitment and reporter transactivation assays. Structure-activity relation studies on I are described.

There is still a lot of research devoted to this compound(SMILES：C(=O)(OC(C)(C)C)[N]2C1=CC(=CC=C1C=C2B(O)O)F)Reference of (1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid, and with the development of science, more effects of this compound(1000068-26-7) can be discovered.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470), published in 2016-12-22, which mentions a compound: 96651-85-3, mainly applied to GPR40 agonist diabetes, Category: benzoxazole.

The G protein-coupled receptor 40 (GPR40) also known as Free Fatty Acid Receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids resulting in amplification of insulin secretion only in the presence of elevated glucose levels. Hypothesis driven structural modifications to endogenous FFAs, focused on breaking planarity and reducing lipophilicity, led to the identification of spiropiperidine and tetrahydroquinoline acid derivatives as GPR40 agonists with unique pharmacol., selectivity and pharmacokinetic properties. Compounds 1 (LY2881835), 2 (LY2922083) and 3 (LY2922470) demonstrated potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion during preclin. testing. A clin. study with 3 administered to subjects with T2DM provided proof of concept of 3 as a potential glucose-lowering therapy. This manuscript summarizes the scientific rationale, medicinal chem., preclin. and early development data of this new class of GPR40 agonists.

If you want to learn more about this compound(2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride)Category: benzoxazole, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(96651-85-3).

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem