Tag: M.W:200-300

In an article, author is Wu, Zhuo, once mentioned the application of 2377-81-3, Name: Tetrafluoroisophthalonitrile, Name is Tetrafluoroisophthalonitrile, molecular formula is C8F4N2, molecular weight is 200.0926, MDL number is MFCD00013290, category is benzoxazole. Now introduce a scientific discovery about this category.

A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT(1) receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 94790-35-9, Name is N-(Chloro(dimethylamino)methylene)-N-methylmethanaminium hexafluorophosphate(V), molecular formula is C5H12ClF6N2P, belongs to benzoxazole compound. In a document, author is Arulmurugan, Subramaniyan, introduce the new discover, SDS of cas: 94790-35-9.

In the present research work, 12 new compounds, such as benzimidazole (3, 3a-c), benzoxazole(4), imidazole(5, 5a-c) and tetrazole(6, 6a-c) were synthesized. FT-IR, Proton NMR (1H), C-13-NMR, Mass spectral values were used to prove the structures of the compounds. The antimicrobial potential of the representative compounds was assessed using the Disc diffusion process. All the benzoxazole, benzimidazole, imidazole and tetrazole derivatives prepared in this investigation show good antimicrobial activity. However the antimicrobial activities of the compounds are less compared with standard drugs. Molecular docking studies have also done for the synthesized compounds all the compounds show hydrogen bond interactions with receptor protein.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 94790-35-9. SDS of cas: 94790-35-9.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Related Products of 165534-43-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 165534-43-0, Name is Diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl) phosphate, SMILES is O=P(OCC)(OCC)ON1N=NC2=CC=CC=C2C1=O, belongs to benzoxazole compound. In a article, author is Kim, Hyong-Jun, introduce new discover of the category.

Fluorescence labeling or sensing is a very useful analytical technique for investigating the structure of living cells or for detecting ionic metals. Numerous materials including inorganic quantum dots and organic fluorescent dyes have been used and investigated for further development so far. However, they are inherited natural discrepancies of cyto-toxicity or easy degradation. Thus, developing highly emissive, biocompatible, and chemically readily modifiable luminescent materials is strongly desired. Here, we report the enhanced photoluminescence of an oxazole derivative for possible use in the field of fluorescent sensor.

Related Products of 165534-43-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 165534-43-0.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 22439-61-8, Name is 2-Bromodibenzo[b,d]thiophene, formurla is C12H7BrS. In a document, author is Spengler, Gabriella, introducing its new discovery. Application In Synthesis of 2-Bromodibenzo[b,d]thiophene.

Background/Aim: Multidrug resistance (MDR) represents a significant impediment to successful cancer treatment. In this study, novel metal [Zn(II), Cu(II), Mg(II), Ni(II), Pd(II), and Ag(I)] complexes of 2-trifluoroacetonyl-benzoxazole previously synthesized and characterized by our group were tested for their MDR-reversing activity in comparison with the free ligands in L5178Y mouse T-lymphoma (MDR) cells transfected with human ATP-binding cassette sub family B member 1 (ABCB1; P-glycoprotein) gene. Materials and Methods: Cytotoxic and antiproliferative effects of the complexes were assessed by the thiazolyl blue tetrazolium bromide (MTT) method. Modulation of ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry. The apoptosis-inducing activity of some complexes was also tested on the multidrug resistant L5178Y mouse T-lymphoma cells, using the annexin-V/propidium iodide assay. Results: When compared to the free ligand, a remarkable enhancement in MDR reversal and cytotoxic activity was found for the Zn(II) and Cu(II) complexes. The activity of the complexes proved to be up to 29- and 5-fold higher than that of the ligands and the ABCB1 inhibitor verapamil as positive control, respectively. The complexes possessed a remarkable potential to induce apoptosis of MDR cells. Conclusion: Our results suggest that the Zn(II) and Cu(II) complexes display significant MDR-reversing activity in a dose-dependent manner and possess strong cytotoxic activity and a remarkable potential to induce apoptosis in MDR L5178Y mouse T-lymphoma cells.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn, Application In Synthesis of 1-Bromo-2-iodobenzene, Especially from a beginner¡¯s point of view. Like 583-55-1, Name is 1-Bromo-2-iodobenzene, molecular formula is benzoxazole, belongs to benzoxazole compound. In a document, author is Singh, Ashish, introducing its new discovery.

Here, we demonstrate mimicking of photophysical properties of native green fluorescent protein (gfp) by immobilizing the gfp chromophore analogues in nanoscale MOF-808 and further exploring the bioimaging applications. The two virtually nonfluorescent gfp chromophore analogues carrying different functionalities, BDI-AE (COOH/COOMe) and BDI-EE (COOMe/COOMe) were immobilized in nanosized MOF-808 via postsynthetic modification. An H-1 NMR and IR study confirms that BDI-AE was coordinated in NMOF-808, whereas BDI-EE was just noncovalently encapsulated. Interestingly, the extremely weakly fluorescent monomers BDI-AE and BDI-EE (QY = 0.01-0.03%, lifetime = 0.01-0.03 ns) showed a 10(2)-fold increase in quantum efficiency with a significantly longer excited-state lifetime (QY = 1.8-5.6%, lifetime 0.89-1.49 ns) after immobilization in the NMOF-808 scaffold. Moreover, BDI-AE@MOF-808 has 4 times higher quantum efficiency as well as longer excited-state lifetime in comparison to BDI-EE@NMOF-808 due to the rigidity imposed in the chromophore upon coordination with Zr4+ in the former case. Further, a cell viability test performed for BDI-AE@NMOF-808 in HeLa cells confirmed the nontoxic nature of the material and, more importantly, bioimaging applications have also been explored successfully.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Electric Literature of 345-92-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 345-92-6, Name is Bis(4-Fluorophenyl)methanone, SMILES is FC1=CC=C(C=C1)C(=O)C1=CC=C(F)C=C1, belongs to benzoxazole compound. In a article, author is Wang Yangdiandian, introduce new discover of the category.

A catalyst system combined of PdCl2 with 1,3-bis(diphenylphosphion)propane (dppp), which was simple and from commercially available materials, was reported for the highly efficient arylation of benzoxazoles at C-2 position with aryl bromides. This catalytic system could tolerate a great number of functional groups in benzoxazole and bromobenzene. With a low PdCl2 loading of 0.01 mol%, aryl bromides could be completely converted into the desired products for 24 h. If the loading of catalyst was up to 0.10 mol%, most of substrates could give more than 90% yields in 6 h. The exploration of the reaction mechanism discovered that Pd nanoparticles were formed during this reaction. The morphology and composition analysis of the Pd nanoparticles with transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) indicated that dppp played a key role to block the aggregation of palladium particles. In addition, the ring-opening pathway of benzoxazoles in the reaction process was proved by control experiments. Hot filtration experimental and high resolution mass spectrum (HRMS) analysis of filtrate suggested that the real active species were Pd(0)-Pd(II)/dppp complexes.

Electric Literature of 345-92-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 345-92-6.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 22439-61-8, Name is 2-Bromodibenzo[b,d]thiophene, molecular formula is , belongs to benzoxazole compound. In a document, author is Aydin, Abdullah, Computed Properties of https://www.ambeed.com/products/22439-61-8.html.

In the molecular structure of the title compound, C24H19Cl2N3O4, the three C atoms of the central N, N-dimethylmethanamine moiety are bonded to the N atoms of the two 5-chloro-1,3-benzoxazol-2(3H)-one groups and to the methyl C atom of the methylbenzene group. One of the nine-membered 2,3-dihydro-1,3-benzoxazole rings and the phenyl ring are almost parallel to each other, making a dihedral angle of 5.30 (18)degrees, but they are almost normal to the mean plane of the other nine-membered 2,3-dihydro-1,3-benzoxazole ring, subtending dihedral angles of 89.29 (16) and 85.41 (18)degrees, respectively. The crystal structure features C-H center dot center dot center dot O hydrogen bonds and pi-pi stacking interactions [centroid-to-centroid distances = 3.5788 (19) angstrom, slippage = 0.438 and 3.7773 (16) angstrom, and slippage = 0.716 angstrom].

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 22439-61-8, in my other articles. Computed Properties of https://www.ambeed.com/products/22439-61-8.html.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 345-92-6, Name is Bis(4-Fluorophenyl)methanone, molecular formula is C13H8F2O, belongs to benzoxazole compound. In a document, author is Ghani, Usman, introduce the new discover, Quality Control of Bis(4-Fluorophenyl)methanone.

In this work a total of 12 carbazoles and hydrazone-bridged thiazole-pyrrole derivatives have been identified as new competitive inhibitors of tyrosinase. Carbazole derivative with 2-benzoimidazole substitution showed most potent inhibition in the series. Other carbazole derivatives containing benzothiazole and benzoxazole substitutions showed comparable levels of tyrosinase inhibition. The hydrazone derivatives also showed potent tyrosinase inhibitory activity with comparable K-i values except one with fluoride at its terminal position. Kinetic studies showed competitive inhibition of tyrosinase by all compounds that increased the substrate K-m without changing the V-max value. Moreover, experimental evidence suggests that the target compounds specifically bind to the binuclear copper center of the tyrosinase active site in an apparent mono-dentate fashion. Carbazoles and hydrazones are new and emerging classes of compounds as tyrosinase inhibitors that may provide new structural avenues to discovery of drugs targeting the treatment of hyperpigmentation and related dermatological disorders.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 345-92-6. Quality Control of Bis(4-Fluorophenyl)methanone.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2377-81-3, Name is Tetrafluoroisophthalonitrile, molecular formula is C8F4N2. In an article, author is Alheety, Nuaman F.,once mentioned of 2377-81-3, Product Details of 2377-81-3.

This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compound (N1) was treated with formaldehyde, it afforded the compound (N8). Also, the N9 was obtained from the reaction of N1 with chloroacetic acid in the presence of alcoholic potassium hydroxide. The prepared compounds were characterized using physico-chemical and spectroscopic methods such as melting point, infrared spectroscopy (IR) and the proton nuclear magnetic resonance (H-1-NMR). Thereafter, some of the compounds were selected for in vitro antibacterial activity and one of these compounds showed an inhibition effect against gram positive only which is very important because it is considered as specific antibacterial drug.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

In an article, author is Jackson, Abigail C., once mentioned the application of 94790-35-9, Formula: https://www.ambeed.com/products/94790-35-9.html, Name is N-(Chloro(dimethylamino)methylene)-N-methylmethanaminium hexafluorophosphate(V), molecular formula is C5H12ClF6N2P, molecular weight is 280.5794, MDL number is MFCD01862891, category is benzoxazole. Now introduce a scientific discovery about this category.

Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-beta-Lactamase NDM-1

Bacterial expression of beta-lactamases, which hydrolyze beta-lactam antibiotics, contributes to the growing threat of antibacterial drug resistance. Metallo-beta-lactamases, such as NDM-1, use catalytic zinc ions in their active sites and hydrolyze nearly all clinically available beta-lactam antibiotics. Inhibitors of metallo-beta-lactamases are urgently needed to overcome this resistance mechanism. Zinc-binding compounds are promising leads for inhibitor development, as many NDM-1 inhibitors contain zinc-binding pharmacophores. Here, we evaluated 13 chelating agents containing benzimidazole and benzoxazole scaffolds as NDM-1 inhibitors. Six of the compounds showed potent inhibitory activity with IC50 values as low as 0.38 mu M, and several compounds restored the meropenem susceptibility of NDM-1-expressing E. coli. Spectroscopic and docking studies suggest ternary complex formation as the mechanism of inhibition, making these compounds promising for development as NDM-1 inhibitors.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem