Tag: M.W:200-300

16707-41-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 16707-41-8, molecular formula is C17H10N2O3, introducing its new discovery.

AFFINITY TAG LABELED NUCLEOSIDES AND USES

Nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.16707-41-8, you can also check out more blogs about16707-41-8

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

64037-07-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 64037-07-6, molcular formula is C7H5BrN2O, introducing its new discovery.

A pyrazole compound and its preparation method and application (by machine translation)

The present invention provides a pyrazole compound and its preparation method and application, the pyrazole compound in the pyrazole is introduced on the 2 – trinitrc and oxazole group after synthesis, the compound low toxic side effect, oral bioavailability is high, human breast cancer cells, lung cancer cells, human prostate cancer cell, human stomach cancer cell and human malignant brain glioma cells and the like for various tumor cells have prominent inhibit function, to develop high-efficiency, low toxicity of the antineoplastic drug to provide new possibilities; and synthesizing the compound raw materials with broad sources, synthetic step is simple, convenient to industrial production. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 64037-07-6, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 64037-07-6

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

5579-85-1, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5579-85-1, name is 6-Bromo-5-chlorobenzo[d]oxazol-2(3H)-one, introducing its new discovery.

3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID DERIVATIVES AS KMO INHIBITORS

A compound of formula (I) or a salt thereof are provided wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington’s disease, Alzheimer’s disease, spinocerebellar ataxias, Parkinson’s disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.5579-85-1, you can also check out more blogs about5579-85-1

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

64037-07-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 64037-07-6, C7H5BrN2O. A document type is Article, introducing its new discovery.

Development and scale-up of an efficient miyaura borylation process using tetrahydroxydiboron

A revised Miyaura borylation process has been developed using tetrahydroxydiboron that avoids the use of bis(pinacolato) diboron and hence the need to hydrolyze the resulting boronic ester to its corresponding acid. The process was greatly simplified and successfully scaled-up in the pilot plant on a 65 kg scale, reducing plant cycle time and resulting in a 47% overall cost reduction. Furthermore, methodology for the study of the oxygen sensitivity of the process is reported that allowed for optimization of the amount of tetrahydroxydiboron and catalyst used. These studies also demonstrated an oxygen-induced decomposition of tetrahydroxydiboron.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Name is 6-Bromobenzo[d]oxazol-2(3H)-one, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 19932-85-5, its synthesis route is as follows.,19932-85-5

General procedure: 6-bromobenzo[d]thiazol-2(3H)-one, 6-bromobenzo[d]xazol-2(3H)-one or 5-bromobenzo[d]thiazol-2(3H)-one (10 mmol) wasdissolved in 10mL dry DMF. Cesium carbonate (20 mmol) and thecorresponding haloalkane (2-bromopropyl, 1-bromobutyl, 1-bromopentyl, 1-bromohexyl, 2-dimethylaminopropyl chloride, 4-(2-chloroethyl)morpholine) (24 mmol) were added to the solution.The mixture was stirred at 80 C overnight. The solvent was evaporatedunder reduced pressure. The residue was dissolved in ethylacetate (50 mL) and washed with water (2X50 mL). The organiclayer was dried over MgSO4 and evaporated under reducedpressure

With the complex challenges of chemical substances, we look forward to future research findings about 6-Bromobenzo[d]oxazol-2(3H)-one

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Article; Leleu-Chavain, Natascha; Baudelet, Davy; Heloire, Valeria Moas; Rocha, Diana Escalante; Renault, Nicolas; Barczyk, Amelie; Djouina, Madjid; Body-Malapel, Mathilde; Carato, Pascal; Millet, Regis; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 347 – 362;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

5-Bromo-2-ethylbenzo[d]oxazole, cas is 938458-80-1, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,938458-80-1

The intermediate 12 22.0 g (97.3 mmol), Bis(pinacolato)diboron 49.4 g (194.6 mmol), Pd(dppf)Cl2.CH2Cl2 3.97 g (4.87 mmol), potassium acetate (KOAc) 19.0 g (291.9 mmol), and dioxane 486 mL were input into a one-neck 500 mL flask to obtain a mixture. Then, the mixture was refluxed and stirred at 100 C. for 12 hours. After completion of the reaction, the reaction product was subjected to distillation under reduced pressure to remove the solvent from the reaction product. A thus-resulting solid was dissolved in dichloromethane, and filtered using Celite, and washed with dichloromethane. A thus-resulting product was crystallized using hexane, to obtain a solid compound (intermediate 13) 18.0 g (yield: 67.7%).

With the rapid development of chemical substances, we look forward to future research findings about 5-Bromo-2-ethylbenzo[d]oxazole

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Patent; LG Display Co., Ltd.; Ryu, Daewon; Kim, Dohan; Kang, Hyeseung; HAN, Sang Bae; Moon, Seong-Shik; KIM, Kyousic; (211 pag.)US2020/10460; (2020); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

It is a common heterocyclic compound, the benzoxazole compound, 2-(Bromomethyl)benzo[d]oxazole, cas is 73101-74-3 its synthesis route is as follows.,73101-74-3

To 9.1 g (0.043 mol) of 2-bromomethyl-benzooxazole in CH3CN (300 mL) were added 7.39 g (0.045 mol, 1.05 eq) of benzenesulfinic acid sodium salt and 2.27 g (8.6 mmol, 0.2 eq) of 18-crown-6. Stirring was continued overnight, solvent evaporated and a column chromatography afforded 8. 1 g (70%) of 2-benzenesulfonylmethyl-benzooxazole as a white solid, MS: 274 (H+). (Y. Nagao, S. Yamada, E. Fujita, Tet. Lett., 1983,24, 2291)

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Patent; F. HOFFMANN-LA ROCHE AG; WO2005/92856; (2005); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

6-Bromobenzo[d]oxazol-2(3H)-one, cas is 19932-85-5, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,19932-85-5

Step 2: Bromide 1 (12.8 g, 59.6 mmol) was dissolved in anhydrous THF (220 mL), and the solution was cooled to ?78 C. Solutions of MeMgBr (21.9 mL of a 3.0 M solution in Et2O, 65.6 mmol), sec-BuLi (50.4 mL of a 1.3 M solution in cyclohexane, 65.6 mmol), and 1,4-Cyclohexanedione mono-ethylene ketal (11.2 g, 71.5 mmol) in anhydrous THF (10 mL) were added sequentially at 30-minute intervals. After the final addition, the reaction mixture was allowed to warm to room temperature. The reaction was quenched by the addition of 1N HCl (25 mL). The reaction mixture was diluted with EtOAc (500 mL), washed with saturated NaCl (250 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to provide a mixture of 2 and 3, as a brown oil.

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Patent; Nikam, Sham Shridhar; Scott, Ian Leslie; Sherer, Brian Alan; Wise, Lawrence David; US2003/236252; (2003); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

6-Bromobenzo[d]oxazol-2(3H)-one, cas is 19932-85-5, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,19932-85-5

Intermediate 4. 2- oxo-2,3-dihydro-1 ,3-benzoxazole-6-carbaldehyde To a suspension of 6-bromobenzo[d]oxazol-2(3H)-one (6.12g, 28.6mmol) in THF (60ml_) was added, at -78 C and under argon atmosphere, methylmagnesium bromide (10.6ml_ of a 3M solution in diethyl ether, 31 .8mmol) and the reaction mixture was stirred at this temperature fro 30 min. The, an additional amount of THF (240 mL) was added at a rate that the internal temperature was below -50 C. Then, tert-butyllithium (60.6ml_ of a 1.7 M solution in pentane, 103mmol) was slowly added and stirred for 45 min at -78 C. To the yellow suspension DMF (13.4ml_, 181 mmol) was then added, and the reaction mixtures was allowed to warm up to room temperature and stirring wasa continued for 3 additional hours. Water (300ml_) was then added to the crude mixture and the organic solvent was removed under reduced pressure. To the remaining aqueous phase, ethyl acetate (500ml_) and 1 N HCI (150ml_) were added and the the mixture was vigorously stirred and the organic phase was separated. The aqueous phase was further extracted with ethyl acetate (3 x 100 mL) and the combined organic extracts were washed with water, brine, dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure to yield the title compound (4.75g, 96%, 94% purity by UPLC). The compound was used as this without further purification. LRMS (m/z): 162 (M-1 )-

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Patent; ALMIRALL, S.A.; PUIG DURAN, Carlos; AIGUADE BOSCH, Jose; GUAL ROIG, Silvia; PRAT QUINONES, Maria; (149 pag.)WO2016/46390; (2016); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

A common heterocyclic compound, the benzoxazole compound, name is 6-Bromobenzo[d]oxazol-2(3H)-one,cas is 19932-85-5, mainly used in chemical industry, its synthesis route is as follows.,19932-85-5

Intermediate 6. 2-oxo-2,3-dihydro-1 ,3-benzoxazole-6-carbonitrileA mixture of 6-bromo-1 ,3-benzoxazol-2(3H)-one (2 g ; 9.34 mmol) and copper (I ) cyan ide (1 .42 g; 1 5.86 mmol) in 6 m l D M F is heated at 1 50C u nder nitrogen atmosphere for 22 hr. After cooling to room temperature, a solution of 1 .55 g (31 .6 mmol) of sodium cyanide in 32 ml water is added followed by 1 hr stirring. The system is extracted thoroughly with ethyl acetate, washed with brine, dried and concentrated in vacuo to provide 1 .5 g (93 % yield) of the title compound enough pure as to prosecute the syntesis.

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Reference£º
Patent; ALMIRALL, S.A.; AIGUADE BOSCH, Jose; GUAL ROIG, Silvia; PRAT QUINONES, Maria; PUIG DURAN, Carlos; WO2013/68554; (2013); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem