Tag: M.W=300-400

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. HPLC of Formula: C10H15F6N6OP, 148893-10-1, Name is O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate, SMILES is CN(/C(N(C)C)=[N+]1N=[N+]([O-])C2=NC=CC=C21)C.F[P-](F)(F)(F)(F)F, in an article , author is Dadashpour, Sakineh, once mentioned of 148893-10-1.

Synthesis and Anticancer Activity of Benzimidazole/Benzoxazole Substituted Triazolotriazines in Hepatocellular Carcinoma

Background: Receptor Tyrosine Kinases (RTK) are the main family of cell surface receptors for growth factors, hormones and cytokines which are responsible for cell growth and differentiation and are considered as an important therapeutic target in cancer. Objective: The aim of this study was to design, synthesise and conduct the biological evaluation of benzimidazole/benzoxazole substituted triazolotriazines as new anticancer agents. Methods: A series of benzimidazolyl and benzoxazolyl-linked triazolotriazines 8a-e and 9a-e were synthesized as receptor tyrosine kinase inhibitors. Target compounds were evaluated in HGF-induced cell proliferation assay in A549, MCF-7, HepG2 and MDA-MB-231 cancer cells. Results: Hepatocellular carcinoma was the most sensitive cell line towards the tested compounds and 8e was the most potent one on HepG2 cells with an IC50 value of 5.13 mu M which was close to crizotinib (HepG2 IC50 = 4.35 mu M) as a standard c-Met kinase inhibitor. c-Met kinase assay of 8e showed that this compound is not capable of inhibiting this enzyme and subsequently molecular docking confirmed the low affinity of 8e towards cMet active site and its possible anticancer mechanism through VEGFR-2 inhibition. Conclusion: Further in silico predictions revealed that 8e can be a drug candidate with favorable pharmacokinetic properties.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 148893-10-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C10H15F6N6OP.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Related Products of 92-86-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 92-86-4, Name is 4,4′-Dibromobiphenyl, SMILES is BrC1=CC=C(C2=CC=C(Br)C=C2)C=C1, belongs to benzoxazole compound. In a article, author is Paczkowski, Ingrid Maliszewsk, introduce new discover of the category.

2,1,3-Benzothiadiazole dyes conjugated with benzothiazole and benzoxazole: Synthesis, solvatochromism and solid-state properties

Benzothiadiazole (BTD) dyes are an important class of N,S-containing heterocycles that have remarkable optical properties. In this work, two new 2,1,3-benzothiadiazole dyes conjugated with benzothiazole and benzoxazole moieties were synthesized and the optical properties in solutions and in the solid state were investigated. The BTD dyes were synthesized in a single step from cydization of ortho-diamino benzothiazole and ortho-diamino benzoxazole dyes. The photophysical behavior of BTD precursor’s benzoxazole and benzothiazole dyes were also investigated. The dyes present absorption in the UVB (280-315 nm) and UVA (315-400 nm) wavelength and fluorescence in the blue-green visible region. The solvatochromic properties of the dyes were investigated indifferent solvents taking into account the solvent orientation polarizability (Delta f) and E-T (30) polarity solvent parameter. The ground and excited state dipole moments were determined by applying Bakshiev’s and Kawaski-Charnma-Viallet’s formulations. Furthermore, the spectroscopic properties of thin films and powders of BTD dyes were explored. (C) 2020 Elsevier B.V. All rights reserved.

Related Products of 92-86-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-86-4.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Synthetic Route of 307-24-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 307-24-4, Name is Undecafluorohexanoic acid, SMILES is O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F, belongs to benzoxazole compound. In a article, author is Shahini, C. R., introduce new discover of the category.

Benzoxazole and dioxolane substituted benzimidazole-based N-heterocyclic carbene-silver( I) complexes: Synthesis, structural characterization and in vitro antimicrobial activity

A novel series of 1,3-benzoxazole and 1,3-dioxolane substituted benzimidazole-based N-heterocyclic carbene (NHC) precursors (6a-b and 11a-b) and their corresponding NHC-silver(I) acetate (12a-b and 14a-b) and bis-NHC-silver(I) hexafluorophosphate complexes (13a-b and 15a-b) were synthesized and characterized by H-1 NMR, C-13 NMR, ATR-IR spectroscopic methods and elemental analysis techniques. Also, the molecular structure of benzimidazolium salt (6a) and bis-NHC-silver(I) hexafluorophosphate complex (13b) were unambiguously established by single crystal X-ray diffraction analysis. Fascinatingly, bis-NHC-silver(I) hexafluorophosphate complex (13b) was revealed to be dinuclear in nature. All the azolium salts (6a-b and 11a-b) as well as the corresponding silver(I) complexes (12a-b, 13a-b, 14a-b and 15a-b) were evaluated for their antimicrobial potential against Gram positive (Staphylococcus aureus), and a set of Gram negative (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) bacterial strains and two fungi, Candida albicans and Cryptococcus neoformans. Antimicrobial studies revealed the comparable activities of benzimidazolium salts (6a-b and 11a-b) and the silver(I) complexes (12a-b, 13a-b and 15a-b). Whereas, the 1,3-dioxolane substituted benzimidazole-based silver(I) acetate complexes (14a-b) demonstrated excellent potentials with both bacterial and fungal growth inhibition above 95%. (C) 2018 Elsevier B.V. All rights reserved.

Synthetic Route of 307-24-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 307-24-4.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 148893-10-1, Name is O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate, molecular formula is C10H15F6N6OP. In an article, author is Bremond, Emma,once mentioned of 148893-10-1, HPLC of Formula: C10H15F6N6OP.

Effect of substitution on the solid-state fluorescence properties of styrylbenzoxazole derivatives with terminal dicyanomethylene group

Three styrylbenzoxazole derivatives with terminal dicyanomethylene group were studied in order to understand how minor modifications brought to the benzoxazole ring influence the photoluminescence (PL) properties. The three compounds, in which several molecular motions are allowed, were weakly fluorescent in organic solution. Remarkably, the unsubstituted (1) and methoxy (2) derivatives showed clear solid-state luminescence enhancement (SLE). Distinct emission characteristics were attributed to the formation of amorphous and crys-talline particles owing to scanning electron microscopy. These two compounds were also strongly luminescent as microcrystalline powders. Compound 1 that crystallized in herringbone configuration was a better emitter than the methoxy derivative 2, in which intermolecular interactions are more numerous, according to X-ray diffraction analysis. In contrast, compound 3 was virtually not emissive, confirming that in this series of dyes the presence of the hydroxy group is detrimental to PL emission, as rarely observed among SLE-active fluorophores.

Interested yet? Keep reading other articles of 148893-10-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C10H15F6N6OP.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is an experimental science, Recommanded Product: 92-86-4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 92-86-4, Name is 4,4′-Dibromobiphenyl, molecular formula is C12H8Br2, belongs to benzoxazole compound. In a document, author is Rajavelu, Kannan.

Synthesis and DSSC application of triazole bridged dendrimers with benzoheterazole surface groups

Triazole bridged dendrimers with benzoheterazole surface groups were successfully synthesized in high yields by click chemistry via convergent approach. The photophysical properties of the dendrimers reveal that as the generation increases the light absorption ability also increases. The fluorescence intensity gradually decreases as the dendritic generation increases because of fluorescence quenching due to steric crowding of the dendritic arms. On increasing the number of benzoheterazole unit at periphery, the anodic peak was shifted to higher positive potential in cyclic voltammetry. When the synthesized triazole dendrimers are utilized as an additive in the redox couple of a DSSC, the lower generation dendrimers showed better current generating capacity with higher power conversion efficiency than the higher generation dendrimers.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 92-86-4. Recommanded Product: 92-86-4.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

In an article, author is Choi, Myeong A., once mentioned the application of 92-86-4, Name: 4,4′-Dibromobiphenyl, Name is 4,4′-Dibromobiphenyl, molecular formula is C12H8Br2, molecular weight is 311.9999, MDL number is MFCD00000101, category is benzoxazole. Now introduce a scientific discovery about this category.

Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-beta probes

To develop novel CNS penetrant HDAC inhibitors, a new series of HDAC inhibitors having benzoheterocycle were designed, synthesized, and biologically evaluated. Among the synthesized compounds, benzothiazole derivative 9b exhibited a remarkable anti-proliferative activity (GI(50) = 2.01 mu M) against SH-SY5Y cancer cell line in a dose and time-dependent manner, better than the reference drug SAHA (GI(50) = 2.90 mu M). Moreover, compound 9b effectively promoted the accumulation of acetylated Histone H3 and alpha-tubulin through inhibition of HDAC1 and HDAC6 enzymes, respectively. HDAC enzyme assay also confirmed that compound 9b efficiently inhibited HDAC1 and HDAC6 isoforms with IC50 values of 84.9 nM and 95.9 nM. Furthermore, compound 9b inhibited colony formation capacity of SH-SY5Y cells, which is considered a hallmark of cell carcinogenesis and metastatic potential. The theoretical prediction, in vitro PAMPA-BBB assay, and in vivo brain pharmacokinetic studies confirmed that compound 9b had much higher BBB permeability than SAHA. In silico docking study demonstrated that compound 9b fitted in the substrate binding pocket of HDAC1 and HDAC6. Taken together, compound 9b provided a novel scaffold for developing CNS penetrant HDAC inhibitors and therapeutic potential for CNS-related diseases.

If you are interested in 92-86-4, you can contact me at any time and look forward to more communication. Name: 4,4′-Dibromobiphenyl.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 148893-10-1, Name is O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate, molecular formula is C10H15F6N6OP, belongs to benzoxazole compound, is a common compound. In a patnet, author is Kotha, Sambasivarao, once mentioned the new application about 148893-10-1, Computed Properties of C10H15F6N6OP.

Synthesis of C-3-Symmetric star-shaped molecules containing 1,3-azoles via hetero-aryl Heck coupling

We have demonstrated a useful synthetic strategy to assemble star-shaped C-3-symmetric molecules containing 1,3-azole moieties at the periphery. To generate these C-3-symmetric heterocycles, we have employed the Pd/Cu-based coupling reactions. To this end, we have used benzoxazole, benzothiazole, and benzimidazole as coupling partners to generate the corresponding hetero-aryl Heck coupling products. (C) 2019 Published by Elsevier Ltd.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 148893-10-1. The above is the message from the blog manager. Computed Properties of C10H15F6N6OP.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Related Products of 105832-38-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 105832-38-0, Name is 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate, SMILES is C[N+](C)=C(N(C)C)ON1C(CCC1=O)=O.F[B-](F)(F)F, belongs to benzoxazole compound. In a article, author is Saeedi, Roonak, introduce new discover of the category.

Oxidation of sulfides including DBT using a new vanadyl complex of a non-innocent o-aminophenol benzoxazole based ligand

Reaction of a non-innocent o-aminophenol benzoxazole based ligand HLBAP with VOCl3 afforded a vanadyl complex, VOLBIS (SQ), in which SQ is a 2,4-di-tert-butylsemiquinone produced from hydrolysis of HLBAP. The crystal structure of VOLBIS (SQ) exhibits an octahedral geometry with the VO2+ center coordinated by two nitrogen and one oxygen atoms of L-BAP and two oxygen atoms of SQ. Electrochemical studies showed quasi-reversible metal-centered reduction and ligand-centered oxidation of complex. The magnetic moment of VOLBIS (SQ) is consistent with the spin-only value expected for S = 1/2 system. The neutral species of VOLBIS (SQ) is EPR active, which is consistent with a paramagnetic electronic ground state (S = 1/2). This result is in accordance with the vanadyl (IV) moiety surrounded by tridentate iminobenzosemiquinonate anion radical (HLBIS)(center dot-) and benzosemiquinone ligand (SQ)(center dot). The theoretical calculations confirm the experimental results. Furthermore, we present the optimal conditions for maximum efficiency of sulfide oxidation for oxidative desulfurization with hydrogen peroxide and 6 times reusability of catalyst for sulfoxidation of dibenzothiophene.

Related Products of 105832-38-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 105832-38-0 is helpful to your research.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Electric Literature of 6825-20-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 6825-20-3, Name is 3,6-Dibromo-9H-carbazole, SMILES is C3=C2C1=C(C=CC(=C1)Br)[NH]C2=CC=C3Br, belongs to benzoxazole compound. In a article, author is Savchenko, Olga A., introduce new discover of the category.

Intramolecular cyclization of 2-(heteroarylsulfanyl)-N-(3-oxoalkenyl)acetamides: synthesis of 3-(heteroarylsulfanyl)- and 3-sulfanylpyridin-2(1H)-ones

The reaction of 2-chloro-N-(3-oxoalkenyl)acetamides with 1,3-benzothiazole-2(3H)-thione, 1,3-benzoxazole-2(3H)-thione, and 1-methyl-1,3-dihydro-2H-benzimidazole-2-thione led to the formation of 2-(heteroarylsulfanyl)-N-(3-oxoalkenyl)acetamides. By the action of a base, these compounds were converted into pyridin-2(1H)-ones containing a divalent sulfur atom in position C-3 bonded to a heterocyclic ring. Bromination, nitration, alkylation of 3-(1,3-benzothiazol-2-ylsulfanyl)pyridin-2(1H)-ones have been studied. The action of zinc in acetic acid transformed these compounds into 3-sulfanylpyridin-2(1H)-ones.

Electric Literature of 6825-20-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 6825-20-3.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

148893-10-1, Name is O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate, molecular formula is C10H15F6N6OP, belongs to benzoxazole compound, is a common compound. In a patnet, author is Takeda, Yuki, once mentioned the new application about 148893-10-1, Product Details of 148893-10-1.

A novel approach to sesquiterpenoid benzoxazole synthesis from marine sponges: nakijinols A, B and E-G

Nakijinols A, B and analogues E through G, which are structurally unique and biologically significant sesquiterpenoid benzoxazoles, can be efficiently obtained in a highly unified manner from the sesquiterpenoid quinone, smenospongine. The starting material is accessible from the (+)-5-methyl Wieland-Miescher ketone. The synthetic method features strategic construction of the requisite dihydroxylated benzoxazole substructure via the ring closure of the N-(2-hydroxyphenyl)-formamide or -acetamide moiety. The synthesis of nakijinols is reported here for the first time. The absolute configurations of nakijinols A and E were also established.

If you¡¯re interested in learning more about 148893-10-1. The above is the message from the blog manager. Product Details of 148893-10-1.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem