Tag: M.W=400-500

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C21H18Br2N2O, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 301353-96-8, Name is P7C3, molecular formula is C21H18Br2N2O. In an article, author is Yatam, Satyanarayana,once mentioned of 301353-96-8.

Design, Synthesis and Biological Evaluation of 2 (((5-aryl-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazoles: New Antiinflammatory and Antioxidant Agents

The oxadiazole linked benzoxazoles derivatives were designed using scaffold hopping approach and their molecular level interactions with both isoforms of cyclooxygenases, Cyclo OXygenase-1 (COX-1) and CycloOXygenase-2 (COX-2), were carried out using docking protocols. Mini library of oxadiazole linked benzoxazoles derivatives were synthesized and tested for their COX inhibitory activity by invitro enzyme assay. The results indicated that compound 2-(((5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazole (5h), 2-(((5-(4-nitrophenyl)-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazole (5j) and 2-(((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazole (5k) selectively inhibited COX-2 enzyme. The compound 5j exhibited strong selective COX-2 inhibition (IC50=4.83 mu M) followed by compound 5h (IC50=5.10 mu M) and 5k (IC50=6.70 mu M). The invivo anti-inflammatory activity of compound 5j was found to have better efficiency than the standard drug Ibuprofen at both 3h and 5h intervals. The significant molecular level interactions with respect to position of benzoxazole, 1,2,4-oxadiazole and substituted aryl groups in both COX-1 and COX-2 active sites were discussed. Subsequently, 2,2-diphenyl-2-picrylhydrazyl (DPPH) anti-oxidant activity was also checked for all the compounds and the compound 5j was found to be good anti-oxidant among the series with an IC50 of 34.5 mu M.

If you¡¯re interested in learning more about 301353-96-8. The above is the message from the blog manager. Formula: C21H18Br2N2O.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

301353-96-8, Name is P7C3, molecular formula is C21H18Br2N2O, belongs to benzoxazole compound, is a common compound. In a patnet, author is Qu, Yao, once mentioned the new application about 301353-96-8, Formula: C21H18Br2N2O.

Three cuprous coordination polymers based on bisbenzoxazole: Syntheses, structures, luminescence and electrochemical properties

Three cuprous coordination polymers, namely: {[Cu(BBO)(3)]center dot PF6}n (1), {[Cu(BBO)(2)(CH3CN)(2)]center dot BF4}(n) (2) and {[Cu(BBO)(2)(SPPh3)]center dot BF4}n (3), bearing a bisbenzoxazole ligand, 2,2′-(1,4-butanediyl)bis-1,3-benzoxazole (BBO), have been synthesized, and structurally characterized by elemental analyses, IR, UV-Vis and single-crystal X-ray diffraction. The structural analysis revealed that the structures of coordination polymers I and 3 are both three-coordinated and show distorted trigonal planar geometry, but 2 is four-coordinated and a slightly distorted tetrahedron environment. In coordination polymer 1, adjacent copper(I) ions were bridged by three independent BBO to form a two-dimensional planar layer framework in which PF6- anion is filled in the hole. Two BBO link Cu(I) ions into a one-dimensional zigzag chain in coordination polymer 2, while acetonitrile as an ancillary ligand distributed on both sides of the one-dimensional chain. Coordination polymer 3 exhibits a single-stranded helix chain structure by two BBO bridging adjacent copper(I) ions. Luminescence properties investigation show that 1 have two emission peaks, which attributed to pi-pi* and n-pi* transitions. However 2 and 3 only had one emission peak, which may be attributed to [MLCT(d(10)(Cu) -> pi*]. This may be due to the synergy of the auxiliary ligands in coordination polymers 2 and 3. The cyclic voltammogram of 1-3 represent quasi-reversible Cue(2+)/Cu+ pairs. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: benzoxazole, 301353-96-8, Name is P7C3, SMILES is BrC1=CC2=C(N(C3=C2C=C(C=C3)Br)CC(CNC4=CC=CC=C4)O)C=C1, belongs to benzoxazole compound. In a document, author is Kennedy, Aaron D. W., introduce the new discover.

Visible-Light Photoswitching by Azobenzazoles

Three visible-light responsive photoswitches are reported, azobis(1-methyl-benzimidazole) (1), azobis(benzoxazole) (2) and azobis(benzothiazole) (3). Photostationary distributions are obtained upon irradiation with visible light comprising approximately 80 % of the thermally unstable isomer, with thermal half-lives up to 8 min and are mostly invariant to solvent. On protonation, compound 1H(+) has absorption extending beyond 600 nm, allowing switching with yellow light, and a thermal half-life just under 5 minutes. The two isomers have significantly different pK(a) values, offering potential as a pH switch. The absorption spectra of 2 and 3 are insensitive to acid, although changes in the thermal half-life of 3 indicate more basic intermediates that significantly influence the thermal barrier to isomerization. These findings are supported by high-level ab initio calculations, which validate that protonation occurs on the ring nitrogen and that the Z isomer is more basic in all cases.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 301353-96-8. Category: benzoxazole.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

In an article, author is Safaei, Elham, once mentioned the application of 301353-96-8, Recommanded Product: P7C3, Name is P7C3, molecular formula is C21H18Br2N2O, molecular weight is 474.1884, MDL number is MFCD00572918, category is benzoxazole. Now introduce a scientific discovery about this category.

Synthesis and characterization of a novel oxo-bridged binuclear iron(III) complex: its catalytic application in the synthesis of benzoxazoles using benzyl alcohol in water

In the present work, the synthesis and characterization of a novel binuclear oxo-bridged iron(III) complex, (FeLAPIP)(2)O, where L-APIP is the deprotonated form of a tetradentateo-aminophenol-iminopyridine ligand, is described. The iron complex was characterized using different techniques including X-ray crystallography, infrared spectroscopy, UV-Vis, magnetic susceptibility and cyclic voltammetry. The X-ray structure analysis revealed that in the structure of the (FeLAPIP)(2)O complex, each iron(III) is coordinated in a distorted square pyramidal arrangement by an oxo group, three amine nitrogens and one oxygen atom of the o-aminophenolate ligand. The variable-temperature magnetic measurement exhibits strong antiferromagnetic coupling between two iron(III) centers. Cyclic voltammetry measurements showed two kinds of quasireversible events, suggesting the formation of a phenoxyl radical species in the region of the anodic peaks and a metal-centered redox (Fe-III/Fe-II) process at low potential. The catalytic activity of this Fe-complex was evaluated in coupling of 2-aminophenol and benzyl alcohols for the one-pot synthesis of benzoxazoles. The catalyst system showed high catalytic activity in this transformation and benzoxazole derivatives were obtained in good to excellent yields. tert-Butyl hydroperoxide was used as an oxidant and 1.2 mol% of catalyst was needed to accomplish the reaction in water as the green solvent.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 301353-96-8, Name is P7C3, SMILES is BrC1=CC2=C(N(C3=C2C=C(C=C3)Br)CC(CNC4=CC=CC=C4)O)C=C1, in an article , author is Wan, Danyang, once mentioned of 301353-96-8, COA of Formula: C21H18Br2N2O.

Synthesis and properties of novel 6,7-dihydrocyclopenta[5,6-b]benzofuran-based liquid crystal compounds

A novel liquid crystal core unit 6,7-dihydrocyclopenta[5,6-b]benzofuran was designed and three different kinds of liquid crystals2MUF, 2MP4, 2MYO2were synthesised through a facile route which employed palladium-catalysed cascade Sonogashira coupling/cyclisation as a key step. Initially, density function theory calculation illustrated that a compound based on this new unit possessed almost a linear structure. The mesophase and physical properties of these novel compounds were measured and the impacts of the newly designed core unit on these properties were investigated by comparing with two series of analogous materials which contained classical mesogenic cores 1,4-disubstituted benzene andtrans-cyclohexyl benzene, finding that the introduction of 6,7-dihydrocyclopenta[5,6-b]benzofuran into liquid crystals tended to promote the formation of nematic phase while increasing both the melting points and the clearing points of target molecules. Meanwhile, the newly synthesised liquid crystals presented higher birefringences when compared with their corresponding reference compounds, indicating that 6,7-dihydrocyclopenta[5,6-b]benzofuran can be a hopeful candidate for the construction of high birefringence liquid crystals.

Interested yet? Read on for other articles about 301353-96-8, you can contact me at any time and look forward to more communication. COA of Formula: C21H18Br2N2O.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 301353-96-8, Name is P7C3, SMILES is BrC1=CC2=C(N(C3=C2C=C(C=C3)Br)CC(CNC4=CC=CC=C4)O)C=C1, belongs to benzoxazole compound. In a document, author is Ravinaik, B., introduce the new discover, Quality Control of P7C3.

Synthesis and Anticancer Evaluation of Amide Derivatives of 1,3,4-Oxadiazole Linked with Benzoxazole

A novel series of amide 1,3,4-oxadiazole linked benzoxazole derivatives 12a-12j are synthesized and their anticancer activity is screened against four human cancer cell lines including A549 (Lung cancer), MCF7 (Breast cancer), A375 (Melanoma cancer), HT-29 (Colon cancer) using Combretastatin-A4 as a control drug. Among the synthesized compounds, 12c and 12g demonstrate potent anticancer activity against HT-29 cancer cell line with IC50 values of 0.018 and 0.093 mu M, respectively, which is higher than the standard drug.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 301353-96-8 is helpful to your research. Quality Control of P7C3.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Reference of 301353-96-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 301353-96-8, Name is P7C3, SMILES is BrC1=CC2=C(N(C3=C2C=C(C=C3)Br)CC(CNC4=CC=CC=C4)O)C=C1, belongs to benzoxazole compound. In a article, author is Ye, Lu, introduce new discover of the category.

Preparation and gas separation performance of thermally rearranged poly (benzoxazole-co-amide) (TR-PBOA) hollow fiber membranes deriving from polyamides

Flexible poly(benzoxazole-co-amide) (PBOA) gas separation hollow fiber membranes were successfully prepared deriving from ether-containing polyamide precursors by thermal densification with or without a supplementary coating treatment. Compared with polyimide precursors, thermally rearrangement in this work required lower treatment temperature but generated better mechanical properties. Both spinning process and thermal treatment conditions were systemically manipulated to intensify the membrane densification aiming at achieving greatly improved selectivity of the obtained TR-PBOA hollow fiber membranes. It was found that draft ratio had little contribution to selectivity enhancement. Separation performance was substantially improved when precursor fibers were dried using ethanol-hexane exchange method and then thermally treated at 350-390 degrees C TR hollow fibers obtained by combined thermal treatment with coating method exhibited the highest selectivity values in this study.

Reference of 301353-96-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 301353-96-8.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Cui, Wei-Rong, Formula: C21H18Br2N2O.

Low Band Gap Benzoxazole-Linked Covalent Organic Frameworks for Photo-Enhanced Targeted Uranium Recovery

The inherent features of covalent organic frameworks (COFs) make them highly attractive for uranium recovery applications. A key aspect yet to be explored is how to improve the selectivity and efficiency of COFs for recovering uranium from seawater. To achieve this goal, a series of robust and hydrophilic benzoxazole-based COFs is developed (denoted as Tp-DBD, Bd-DBD, and Hb-DBD) as efficient adsorbents for photo-enhanced targeted uranium recovery. Benefiting from the hydroxyl groups and the formation of benzoxazole rings, the hydrophilic Tp-DBD shows outstanding stability and chemical reduction properties. Meanwhile, the synergistic effect of the hydroxyl groups and the benzoxazole rings in the pi-conjugated frameworks significantly decrease the optical band gap, and improve the affinity and capacity to uranium recovery. In seawater, the adsorption capacity of uranium is 19.2x that of vanadium, a main interfering metal in uranium extraction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 301353-96-8, in my other articles. Formula: C21H18Br2N2O.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Erol, Meryem, once mentioned the application of 301353-96-8, Name is P7C3, molecular formula is C21H18Br2N2O, molecular weight is 474.1884, MDL number is MFCD00572918, category is benzoxazole. Now introduce a scientific discovery about this category, Name: P7C3.

Design, synthesis, molecular docking, density functional theory and antimicrobial studies of some novel benzoxazole derivatives as structural bioisosteres of nucleotides

A series of some novel 2-(p-tert-butylphenyl)-5-(3-substituted-propionamido)benzoxazole derivatives have been designed, synthesized, evaluated for antimicrobial activity and have performed molecular docking studies against penicillin-binding protein 4 (PBP4) and active and allosteric site of PBP2a; were calculated some theoretical quantum parameters and absorption, distribution, metabolism and excretion (ADME) descriptors. B9 acted at minimum inhibitory concentration (MIC) = 8 mu g/mL against S. aureus, E. faecalis and their drug-resistant isolates and also formed with GLU145 (1.74 angstrom) and ILE144 (1.89 angstrom) two hydrogen bonds at allosteric site of PBP2a with Glide emodel score: -42.168. Delta E of compound B9 had moderate value of all compounds with 0.14742. Communicated by Ramaswamy H. Sarma

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 301353-96-8, Name is P7C3, molecular formula is C21H18Br2N2O. In an article, author is Zhan, Zhenzhen,once mentioned of 301353-96-8, Name: P7C3.

Selective synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and quinoxaline from aromatic aldehyde and o-phenylenediamine

We have designed a general, inexpensive, and versatile method for the synthesis of (1H-benzo[d]imidazol2- yl)(phenyl)methanone and the formation of C-N bonds via an aromatic aldehyde and o-phenylenediamine. In the presence of N,N-dimethylformamide/sulfur, (1H-benzo[d]imidazol-2-yl)(phenyl)methanone was obtained; however, in the absence of sulfur, quinoxaline was obtained in 1,4-dioxane. A wide range of quinoxalines and (1H-benzo[d]imidazol-2-yl)(phenyl)methanones was obtained under mild conditions.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem