Tag: M.W=500-600

In an article, author is Xu, Yuling, once mentioned the application of 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O, molecular weight is 506.21, MDL number is MFCD28023591, category is benzoxazole. Now introduce a scientific discovery about this category, Product Details of 1235481-90-9.

Mono- and tetranuclear copper(I) complexes with N-heterocyclic chelating and triphenylphosphine ligands: Crystal structures, luminescent and heterogeneous catalytic properties

N-heterocyclic chelating and triphenylphosphine ligands react with cuprous halide to form a variety of copper(I) complexes, namely, mononuclear [Cu(PBO)(PPh3)Br](CH2Cl2)-C-. (1) and [Cu(PBM)(PPh3)I] (2) (PBO=2-(2-Pyridyl)benzoxazole, PBM=2-(2-Pyridyl)benzimidazole, PPh3=triphenylphosphine) and tetranuclear [Cu-4((2)-I)(2)((3)-I)(2)(PPh3)(4)](.)2CH(2)Cl(2) (3) have been synthesized and characterized. Complexes 1 and 2 are basically alike; both of them are mononuclear and four-coordinated, possessing a slightly distorted trigonal pyramidal geometry. Complex 3 is tetranuclear and the coordination numbers of the two copper(I) atoms are three and four, Cu(1) forming an approximate trigonal planar coordination environment, while Cu(2) is a slightly distorted trigonal pyramidal geometry, resulting in a distorted chair-like conformation. Complexes 1 and 2 are emissive in the solid state at ambient temperature, with the maxima at 552 and 602nm, respectively, due to a MLCT excited state. Moreover, complex 3 manifests promising heterogeneous catalytic activities for the degradation of methylene blue (MB), with degradation efficiency of 99% under ambient light.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Wang Neng, once mentioned the application of 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O, molecular weight is 506.21, MDL number is MFCD28023591, category is benzoxazole. Now introduce a scientific discovery about this category, Formula: C22H19Br2FN2O.

Research Progress in Design, Synthesis and Application of Benzo Nitrogen-Containing Heterocyclic Fluorescent Probes

Benzo five-/six-membered nitrogen-containing heterocyclic compound with a rigid plane and a large conjugate structure can emit characteristic fluorescence in a variety of organic solvents and mixed solutions, and N, O, S heteroatoms in the structure can serve as binding sites for fluorescent probes. Therefore, in recent years, benzo nitrogen-containing heterocyclic compounds are increasingly becoming one of the research focuses in the field of fluorescent probes. From the perspective of starting materials, synthesis methods, molecular structure, interaction mechanism, benzo five- / six-membered nitrogen-containing heterocyclic fluorescent probes containing the structure of benzoxazole, benzothiazole, benzimidazole, indole, carbazole. quinoline, benzopyrazine and phenazine are introduced with emphasis. And their detection application for a variety of analytes, such small molecules, metal cations, anions and pH are reviewed. In the future, it is worthy of further attention to the research on the integration of multiple heterocyclic functional structures into a multifunctional fluorescent probe by simple and green synthesis.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O. In an article, author is Ryu, Hwani,once mentioned of 1235481-90-9, Safety of P7C3-A20.

The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis

The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death, with its activation capable of sensitizing cancer cells to radiotherapy or chemotherapy. To identify small molecules that induce apoptosis via increased p53 transcriptional activity, we used a novel in-house library containing 96 small-molecule compounds. Using a cell-based screening method with a p53-responsive luciferase-reporter assay system involving benzoxazole derivatives, we found that AU14022 administration significantly increased p53 transcriptional activity in a concentration-dependent manner. Treatment with AU14022 increased p53 protein expression, p53 Ser15 phosphorylation, p53-mediated expression of downstream target genes, and apoptosis in p53-wild-type HCT116 human colon cancer cells, but not in p53-knockout HCT116 cells. Additionally, p53-wild-type HCT116 cells treated with AU14022 exhibited mitochondrial dysfunction, including modulated expression of B-cell lymphoma-2 family proteins and cytochrome c release. Combination treatment with AU14022 and ionizing radiation (IR) synergistically induced apoptosis as compared with IR or AU14022 treatment alone, with further investigation demonstrating that cell cycle progression was significantly arrested at the G2/M phase following AU14022 treatment. Furthermore, in a mouse p53-wild-type HCT116 colon cancer xenograft model, combined treatment with AU14022 and IR inhibited tumor growth more effectively than radiation alone. Therefore, AU14022 treatment induced apoptosis through p53-mediated cell cycle arrest involving mitochondrial dysfunction, leading to enhanced radiosensitivity in colon cancer cells. These results provide a basis for further assessments of AU14022 as a promising anticancer agent.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O, belongs to benzoxazole compound. In a document, author is Carayon, Chantal, introduce the new discover, Product Details of 1235481-90-9.

Mechanofluorochromic Properties of an AIEE-Active 2-Phenylbenzoxazole Derivative: More than Meets the Eye?

The presence of a dicyanovinyl group on the robust 2-phenylbenzoxazole framework led to the emergence of aggregation-induced emission enhancement (AIEE) characteristics. A mechanofluorochromic (MFC) behaviour was observed. The pristine microcrystals emitted yellow-green light, which became golden yellow upon grinding, with the reverse process observed upon heating or solvent fuming. This phenomenon was accompanied by a reversible evolution of the photoluminescence quantum yields and lifetimes. These variations were attributed to the formation of different types of emissive species in the crystalline phases and in the ground material, which is a mixture of very small microcrystals and amorphous matter. Remarkably, evidence was also given for other spectroscopic effects, which depend on the size, compactness and heterogeneity of the solid samples. These effects are presumably linked to the generation of regions rich in low-energy exciton traps in polycrystalline and pressed samples, and to light reabsorption. They are enhanced by the fact that the pristine platelets exhibit self-waveguided edge emission, and they are all the more significant as the MFC effect is rather weak.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 1235481-90-9. Product Details of 1235481-90-9.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Synthetic Route of 1235481-90-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1235481-90-9, Name is P7C3-A20, SMILES is COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1, belongs to benzoxazole compound. In a article, author is Wang Yangdiandian, introduce new discover of the category.

Pd/1,3-Bis(diphenylphosphino)propane Catalyzed Arylation of Benzoxazoles at C-2 Position with Aryl Bromides

A catalyst system combined of PdCl2 with 1,3-bis(diphenylphosphion)propane (dppp), which was simple and from commercially available materials, was reported for the highly efficient arylation of benzoxazoles at C-2 position with aryl bromides. This catalytic system could tolerate a great number of functional groups in benzoxazole and bromobenzene. With a low PdCl2 loading of 0.01 mol%, aryl bromides could be completely converted into the desired products for 24 h. If the loading of catalyst was up to 0.10 mol%, most of substrates could give more than 90% yields in 6 h. The exploration of the reaction mechanism discovered that Pd nanoparticles were formed during this reaction. The morphology and composition analysis of the Pd nanoparticles with transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) indicated that dppp played a key role to block the aggregation of palladium particles. In addition, the ring-opening pathway of benzoxazoles in the reaction process was proved by control experiments. Hot filtration experimental and high resolution mass spectrum (HRMS) analysis of filtrate suggested that the real active species were Pd(0)-Pd(II)/dppp complexes.

Synthetic Route of 1235481-90-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1235481-90-9 is helpful to your research.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry, like all the natural sciences, Computed Properties of C22H19Br2FN2O, begins with the direct observation of nature¡ª in this case, of matter.1235481-90-9, Name is P7C3-A20, SMILES is COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1, belongs to benzoxazole compound. In a document, author is Glamoclija, Una, introduce the new discover.

Synthesis, Biological Evaluation and Docking Studies of Benzoxazoles Derived from Thymoquinone

Thymoquinone (TQ), a natural compound with antimicrobial and antitumor activity, was used as the starting molecule for the preparation of 3-aminothymoquinone (ATQ) from which ten novel benzoxazole derivatives were prepared and characterized by elemental analysis, IR spectroscopy, mass spectrometry and NMR (H-1, C-13) spectroscopy in solution. The crystal structure of 4-methyl-2-phenyl-7-isopropyl-1,3-benzoxazole-5-ol (1a) has been determined by X-ray diffraction. All compounds were tested for their antibacterial, antifungal and antitumor activities. TQ and ATQ showed better antibacterial activity against tested Gram-positive and Gram-negative bacterial strains than benzoxazoles. ATQ had the most potent antifungal effect against Candida albicans, Saccharomyces cerevisiae and Aspergillus brasiliensis. Three benzoxazole derivatives and ATQ showed the highest antitumor activities. The most potent was 2-(4-fluorophenyl)-4-methyl-7-isopropyl-1,3-benzoxazole-5-ol (1f). Western blot analyses have shown that this compound inhibited phosphorylation of protein kinase B (Akt) and Insulin-like Growth Factor-1 Receptor (IGF1R ) in HeLa and HepG2 cells. The least toxic compound against normal fibroblast cells, which maintains similar antitumor activities as TQ, was 2-(4-chlorophenyl)-4-methyl-7-isopropyl-1,3-benzoxazole-5-ol (1e). Docking studies indicated that 1e and 1f have significant effects against selected receptors playing important roles in tumour survival.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1235481-90-9. Computed Properties of C22H19Br2FN2O.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O, belongs to benzoxazole compound, is a common compound. In a patnet, author is Song, Ming-Xia, once mentioned the new application about 1235481-90-9, COA of Formula: C22H19Br2FN2O.

Design, synthesis, and evaluation of anticonvulsant activities of benzoxazole derivatives containing the 1,2,4-triazolone moiety

A novel series of benzoxazole derivatives containing 1,2,4-triazolone (5a-m) was designed. These compounds were synthesized in order to screen their anticonvulsant activities by the maximal electroshock seizure (MES) model and the subcutaneous pentylenetetrazole (sc-PTZ) seizure model in mice. The rotarod test was used to evaluate their neurotoxicities. Most of the compounds showed anti-MES activities at 100 and 300 mg/kg. Compound 5f, which showed potential anticonvulsant activity in the MES model with ED50 values of 22.0 mg/kg, was considered as the most promising one in this study. It exhibited greater safety than that of carbamazepine and valproate regarding neurotoxicity. The efficacy of compound 5f in inhibiting the tonic seizures and death induced by the convulsants 3-mercaptopropionic acid and BIC was also verified. In an enzyme-linked immunosorbent assay, compound 5f and the positive drug phenytoin significantly increased the gamma-aminobutyric acid (GABA) level in the mouse brain. Further, pretreatment with an inhibitor of the GABA synthesizing enzyme dramatically raised the ED50 value of 5f in the MES model. These results confirmed that the compound 5f plays its anticonvulsive action via regulating the GABA function in the brain. Also, a docking study of the compound 5f in the benzodiazepine (BZD) binding site of the GABA(A) receptor confirmed possible binding of the compound 5f with BZD receptors.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 1235481-90-9. The above is the message from the blog manager. COA of Formula: C22H19Br2FN2O.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C22H19Br2FN2O, 1235481-90-9, Name is P7C3-A20, SMILES is COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1, belongs to benzoxazole compound. In a document, author is Tutone, Marco, introduce the new discover.

Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

Translational readthrough-inducing drugs (TRIDs ) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been synthesized and tested using the Fluc reporter harboring the UGA PTC. Moreover, the cytotoxic effect and the expression of the CFTR protein were evaluated. These compounds, a benzimidazole derivative (NV2899), a benzoxazole derivative (NV2913), a thiazole derivative (NV2909), and a benzene-1,3-disulfonate derivative (NV2907), were shown to be potential new lead compounds as TRIDs, boosting further efforts to address the optimization of the chemical scaffolds.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1235481-90-9. Computed Properties of C22H19Br2FN2O.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1235481-90-9, Name is P7C3-A20, SMILES is COC1=CC(NCC(F)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3)=CC=C1, in an article , author is Kim, Hyong-Jun, once mentioned of 1235481-90-9, Recommanded Product: P7C3-A20.

Fluorescent Nano-Assembly of Organic Conjugate Molecules with Benzoxazole Moiety and Its Application in Sensor

Fluorescence labeling or sensing is a very useful analytical technique for investigating the structure of living cells or for detecting ionic metals. Numerous materials including inorganic quantum dots and organic fluorescent dyes have been used and investigated for further development so far. However, they are inherited natural discrepancies of cyto-toxicity or easy degradation. Thus, developing highly emissive, biocompatible, and chemically readily modifiable luminescent materials is strongly desired. Here, we report the enhanced photoluminescence of an oxazole derivative for possible use in the field of fluorescent sensor.

Interested yet? Read on for other articles about 1235481-90-9, you can contact me at any time and look forward to more communication. Recommanded Product: P7C3-A20.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Wang Wei-Na, once mentioned the application of 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O, molecular weight is 506.21, MDL number is MFCD28023591, category is benzoxazole. Now introduce a scientific discovery about this category, SDS of cas: 1235481-90-9.

Synthesis and spectral properties of a novel fluorescent probe for Zn2+ based on a benzoxazole fluorophore

A novel turn-on fluorescent probe containing a benzoxazole fluorophore has been synthesised and its response to different metal ions has been investigated by spectrometry. The probe was highly selective and sensitive to Zn2+ and showed a complexation ratio towards Zn2+ of 1:1. It also exhibited a linear response range for Zn2+ from 0.3 to 4.8 mu mol L-1 with a detection limit of 0.36 mu mol L-1.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem