1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
A new synthetic method for the synthesis of N-phosphinyl sulfoximines that proceeds by an I2-catalyzed oxidative N-P cross-coupling reaction has been developed. N-phosphinylated sulfoximines are synthesized from sulfoximines and diarylphosphine oxides using 10 mol% I2 as a catalyst, one equiv H2O2 as a green oxidant and PEG400 as a greener solvent. Chirality of S-methyl-S-phenylsulfoximine is retained in the coupling products (100% ee).
I2-Catalyzed Oxidative N-P Cross-Coupling of Diarylphosphine Oxides and Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem