Thallium in organic synthesis. 65. A novel synthesis of benzoxazoles from anilides was written by Taylor, Edward C.;Katz, Alan H.;Alvarado, Sergio I.;McKillop, Alexander. And the article was included in Journal of Organic Chemistry in 1986.HPLC of Formula: 5676-58-4 This article mentions the following:
Benzoxazoles I (R = Me, Ph, 4-ClC6H4; R1 = H, Me, CHMeCO2Me; R2 = H, Me) are readily formed by photolysis of the regiospecifically ortho-thallated anilides II. This new methodol. was used for a synthesis of benoxaprofen (I, R = 4-ClC6H4, R1 = CHMeCO2H, R2 = H) which exploits a second thallium-mediated reaction of 3-EtCOC6H4NHCOC6H4Cl-4 with HC(OMe)3 for generation of the α-methylacetic acid substituent. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.HPLC of Formula: 5676-58-4
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem