22876-22-8, An article , which mentions 22876-22-8, molecular formula is C8H7NOS. The compound – 5-Methylbenzo[d]oxazole-2(3H)-thione played an important role in people’s production and life.
The first low muM SecA inhibitors
SecA ATPase is a critical member of the Sec family, which is important in the translocation of membrane and secreted polypeptides/proteins in bacteria. Small molecule inhibitors can be very useful research tools as well as leads for future antimicrobial agent development. Based on previous virtual screening work, we optimized the structures of two hit compounds and obtained SecA ATPase inhibitors with IC50 in the single digit micromolar range. These represent the first low micromolar synthetic inhibitors of bacterial SecA and will be very useful for mechanistic studies.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem