One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 3889-13-2, Name is 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, molecular formula is C7H4N2O4
Radiosynthesis and evaluation of acetamidobenzoxazolone based radioligand [11C]N?-MPB for visualization of 18 kDa TSPO in brain
The 18 kDa translocator protein (TSPO) is a viable target for imaging of inflammation in brain. In the recent past we have explored a pharmacophore skeleton acetamidobenzoxazolone for positron emission tomography (PET) imaging of TSPO expression in brain. Here we evaluated a new radioligand for visualization of TSPO, namely [11C]N-(2-methoxyoxyphenyl)-N-methyl-2-(5-nitro-2-oxobenzo[d]oxazol-3(2H)-yl)acetamide ([11C]N?-MPB). This PET ligand exhibited high binding affinity towards TSPO (Ki = 4.9 nM) and a suitable lipophilicity (log D) of 2.08 for brain imaging. A biodistribution study on mice showed high accumulation of radioactivity in TSPO-rich organs, such as the lungs, heart, kidneys, and adrenal glands. Metabolite analysis of rat brain homogenate showed 98% intact [11C]N?-MPB at 30 min after injection. To determine the specific binding of the radioligand with TSPO on neuroinflammation of the brain, in vitro autoradiography and PET studies were performed in an ischemic rat model. In vitro autoradiography indicated significantly increased binding on the ipsilateral side compared with that on the contralateral side of ischemic rat brains. This result was supported firmly by the contrast of radioactivity in PET images. Displacement experiments with PK11195 minimized the difference in radioactivity uptake between the two sides. In summary, [11C]N?-MPB is a potential PET imaging radioligand for TSPO and, consequently, for gaining more insight for up-regulation of microglia during neuroinflammation.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3889-13-2, in my other articles.
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem