So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gerten, Anthony L.; Stanley, Levi M. researched the compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole( cas:503538-69-0 ).COA of Formula: C38H24F4O4P2.They published the article 《Enantioselective dearomative [3 + 2] cycloadditions of indoles with azomethine ylides derived from alanine imino esters》 about this compound( cas:503538-69-0 ) in Organic Chemistry Frontiers. Keywords: indole azomethine ylide copper difluorphos catalyst dearomative cycloaddition; pyrroloindoline enantioselective diastereoselective preparation. We’ll tell you more about this compound (cas:503538-69-0).
Catalytic, enantioselective [3 + 2] cycloadditions of azomethine ylides derived from alanine imino esters with 3-nitroindoles were reported. The dearomative cycloaddition reactions occurred in the presence of a catalyst generated in situ from Cu(OTf)2 and (R)-Difluorphos to form exo’-pyrroloindoline cycloadducts and established four contiguous stereogenic centers, two of which were fully substituted. The exo’-pyrroloindoline products were formed in moderate-to-good yields (39-85%) with high diastereoselectivities (up to 98 : 1 : 1 dr) and enantioselectivities (up to 96% ee).
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem