As a common heterocyclic compound, it belongs to benzoxazole compound, name is 2-Chloro-6-fluorobenzo[d]oxazole, and cas is 153403-53-3, its synthesis route is as follows.
To a solution of N-[(1S, 25)-2-arninocyclopentyl]-2-(difluoromethoxy)benzamide hydrochloride (Intermediate 11; 45 mg, 0.15 mmol) in DMSO (0.5 ml) was added DIPEA (57 mg, 0.44 mmol) and 2-chloro-6-fluoro-l,3-benzoxazole (CAS number 153403-53-3; 30 mg, 0.17 mmol). The reaction mixture was heated to 140C for 4 hours then partitioned between ethyl acetate and water. The organics were washed with water and brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography (silica, 30 – 80% ethyl acetate / petrol) then purified further by reverse phase chromatography (C 8 silica, 5-95% water (with 0,05% ammonia) / (0606) acetonitrile) to afford the title compound. (0607) 3H NMR (400 MHz, DMSO- ) delta ppm 1.53 – 1 .67 (m, 2 H), 1 .67 – 1 .81 (m, 2 H), 2.01 – 2.18 (m, 2 }. 4.06 – 4.19 (m, 1 H), 4.22 – 4.32 (m, 1 H), 6.88 – 7.38 (m, 4 H), 7.52 – 7.65 (m, 1 H), 7.67 – 7.79 (m, 1 H), 8.03 – 8.17 (m, 1 H), 8.44 – 8.53 (m, 1 H), 8.77 – 8.87 (m, 1 H) (0608) MS ES+: 407
153403-53-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,153403-53-3 ,2-Chloro-6-fluorobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see
Reference：
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; FUJIMOTO, Tatsuhiko; ROBINSON, John Stephen; WO2015/124934; (2015); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem