So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Zhenhua; Jin, Guoqiang; Qin, Jingjing; Tan, Zhiyong; He, Jiayu researched the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3 ).SDS of cas: 6797-13-3.They published the article 《Efficient and divergent synthesis of benzoxazoles and 1,2-benzisoxazoles from o-hydroxyaryl ketoximes》 about this compound( cas:6797-13-3 ) in Heterocycles. Keywords: hydroxy acetophenone oxime tandem Beckmann rearrangement regioselective oxacyclization; benzoxazole preparation; benzisoxazole preparation. We’ll tell you more about this compound (cas:6797-13-3).
A bis(trichloromethyl) carbonate (BTC) / triphenylphosphine oxide (TPPO) system promoting tunable cyclization of a variety of o-hydroxyaryl ketoximes to benzoxazoles and benzisoxazoles was developed. The synthetic switch was enabled by base-free or the use of Et3N. Under base-free conditions, o-hydroxyaryl ketoximes were treated with BTC/TPPO giving corresponding 2-substituted benzoxazoles via cascaded Beckmann rearrangement and intramol. oxa-cyclization. Analogously, the 3-substituted benzisoxazoles were obtained via intramol. nucleophilic substitution reactions in the presence of Et3N. This process features mild reaction conditions, high chemoselectivity and good functional groups tolerance.
Different reactions of this compound(2-Ethylbenzo[d]oxazole)SDS of cas: 6797-13-3 require different conditions, so the reaction conditions are very important.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem