701-16-6, Name is 5-Fluoro-2-methylbenzo[d]oxazole, belongs to benzoxazole compound, is a common compound. Quality Control of 5-Fluoro-2-methylbenzo[d]oxazoleIn an article, once mentioned the new application about 701-16-6.
Utility of Nitrogen Extrusion of Azido Complexes for the Synthesis of Nitriles, Benzoxazoles, and Benzisoxazoles
The utility of the nitrogen extrusion reaction of azido complexes, generated in situ from the corresponding aldehydes or ketones with TMSN3 in the presence of ZrCl4 or TfOH, has been described. These azido complexes could undergo three different pathways, depending on the substrates. First, azido methanolate complexes or imine diazonium ions could lead to benzisoxazole products via an intramolecular nucleophilic substitution. Second, imine diazonium ions could also undergo either the elimination of proton to provide nitrile products in good to excellent yields or an aryl migration, followed by an intramolecular nucleophilic addition, to give benzoxazole products in good yields.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem