81282-60-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7-Aminobenzo[d]oxazol-2(3H)-one, cas is 81282-60-2,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
A solution of Ms20 (32 1 g, 184.8 mmol) in MeCN (200 mL) was cooled to < -5 C (ice/H20 salt) and sequentially were added a solution of N-benzyl-bis(2- hydroxyethyl)amine (16.4 g, 84.1 mmol) in MeCN (50 mL), Et3N (36 mL, 255 mmol, 3.8 eq.), and MsOH (13.1 mL, 202 mmol, 3 eq.) while maintaining the temperature below 10C. 7-Aminobenzo[d]oxazol-2(3H)-one (10.0 g, 67.2 mmol) was added as a solid and the mixture was heated to reflux. Et3N (28.5 mL, 202 mmol) was added drop- wise over a period of 1.5 hour. Reflux was maintained for 18 additional hours. The resulting clear solution was allowed to cool to RT and concentrated in vacuo at 70C. The residue was separated between NaHCC (0.8 L) and EtOAc (0.4 L). The aqueous layer was extracted with EtOAc (3 x 0.2 L). The combined organic layers were washed with brine, dried (NaiSC^) and concentrated to afford 7-(4-benzylpiperazin-l- yl)benzo[d]oxazol-2(3H)-one as a white solid (20.2 g, 65.3 mmol, 97%).
The chemical industry reduces the impact on the environment during synthesis,81282-60-2,7-Aminobenzo[d]oxazol-2(3H)-one,I believe this compound will play a more active role in future production and life.
Reference：
Patent; AAPA B.V.; HEERES, Andre; WILLIGERS – HOGG, Sandra; BORST, Marcus Leonardus Gerardus; DROeGE, Melloney Joyce; WO2015/69110; (2015); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem