Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 503538-69-0, is researched, Molecular C38H24F4O4P2, about Catalytic Enantioselective Alkylative Aldol Reaction: Efficient Multicomponent Assembly of Dialkylzincs, Allenic Esters, and Ketones toward Highly Functionalized δ-Lactones with Tetrasubstituted Chiral Centers, the main research direction is lactone pyranone dihydro asym synthesis; ketone stereoselective multicomponent alkylative aldol dialkylzinc allenoate.Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.
A general catalytic asym. alkylative aldol reaction is described as a new entry to the catalytic asym. multicomponent reaction (CAMCR). Highly functionalized δ-lactones I (R1 = Me2CHCH2, H2C:CHCH2CH2, Ph, cyclohexyl, 1-cyclohexenyl, 4-BrC6H4, 4-MeOC6H4, R2 = Me; R1R2 = 1,2,3,4-tetrahydronaphthalene-1,1-diyl; R3 = Me, Et, Me2CH, n-Bu) were produced in the presence of a catalytic amount of the Cu(OAc)2-DIFLUORPHOS complex through three-component assembly of dialkylzincs R32Zn, allenic ester H2C:CHCO2Et, and unactivated ketones R1COR2. This CAMCR constructs two C-C bonds and one tetrasubstituted chiral center simultaneously. Conjugate addition of alkylcopper species to an allenic ester produced highly active copper enolate in situ, and the successive asym. aldol addition to ketones followed by lactonization afforded the desired products. The addition of 4A mol. sieves and a Lewis base (Ph2S:O, DMSO, or HMPA) is important for obtaining a high yield, with suppression of the undesired α-addition pathway. Control/crossover experiments suggest that the addition of a Lewis base facilitated the retro-aldol reaction of the α-adducts (proofreading effect). The ketone and copper enolate generated through the retro-aldol reaction were converted to the desired lactone through the γ-aldol pathway, which was trapped by irreversible lactone formation.
There is still a lot of research devoted to this compound(SMILES：FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1)Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and with the development of science, more effects of this compound(503538-69-0) can be discovered.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem