Eco-friendly syntheses of 2-substituted benzoxazoles and 2-substituted benzothiazoles from 2-aminophenols, 2-aminothiophenols and DMF derivatives in the presence of imidazolium chloride was written by Tian, Qingqiang;Luo, Wen;Gan, Zongjie;Li, Dan;Dai, Zeshu;Wang, Huajun;Wang, Xuetong;Yuan, Jianyong. And the article was included in Molecules in 2019.SDS of cas: 5676-58-4 This article mentions the following:
A simple, economical and metal-free approach to the synthesis of 2-substituted benzoxazoles/benzothiazoles I (R = H, 6-Me, 5-Cl, 6-NO2, etc.; R1 = Me, Ph, pyridin-2-yl, 3-oxo-3-phenylpropyl, etc.; X = O, S) in moderate to excellent yields from 2-aminophenols/2-aminothiophenols R2-2-NH2C6H3XH (R2 = H, 5-Me, 4-Cl, 5-NO2, etc.) and DMF derivatives, only using imidazolium chloride (50% mmol) as promoter without any other additive, was reported. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.SDS of cas: 5676-58-4
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem