Synthesis of N-aryl-2-aminobenzoxazoles from substituted benzoxazole-2-thiol and 2-chloro-N-arylacetamides in KOH-DMF system was written by Wang, Guang-cheng;Wang, Jing;Li, Lu-yao;Chen, Shan;Peng, Ya-ping;Xie, Zhen-zhen;Chen, Ming;Deng, Bin;Li, Wen-biao. And the article was included in Heterocycles in 2017.Product Details of 23417-29-0 This article mentions the following:
A simple and novel method for the synthesis of N-aryl-2-aminobenzoxazoles I [R1 = H, 5-F, 6-Me, etc. ; R2 = 4-Cl, 2,4-di-Me, 4-OPh, etc.] from substituted benzoxazole-2-thiols II and 2-chloro-N-arylacetamides R2C6H4NHC(O)CH2Cl in KOH-DMF system has been developed. The present protocol provides an attractive approach to access various N-aryl-2-aminobenzoxazoles I in moderate to good yields without using transition metal catalyst under very mild reaction condition. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Product Details of 23417-29-0).
6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Product Details of 23417-29-0
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem