On January 21, 2022, Wang, Zheng-Hai; Wang, Dong-Hui published an article.Category: benzoxazole The title of the article was Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime. And the article contained the following:
A Cu-catalyzed straightforward synthesis of benzoxazoles I [R = 5-iPr, 5-NHAc, 7-Bn, etc.; Ar = Ph, 1-naphthyl, 2-furyl, etc.] from free phenols and cyclic oxime esters was reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps were demonstrated. A catalytic mechanism, which included Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, was proposed. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Category: benzoxazole
The Article related to benzoxazole preparation, phenol cyclic oxime ester amination copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Category: benzoxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem