What I Wish Everyone Knew About 2343-89-7

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2343-89-7 help many people in the next few years. Formula: C4H5FO2.

2343-89-7, Name is Methyl 2-fluoroacrylate, molecular formula is C4H5FO2, Formula: C4H5FO2, belongs to benzoxazole compound, is a common compound. In a patnet, author is Imaizumi, Takamichi, once mentioned the new application about 2343-89-7.

The design, synthesis and evaluation of 2-aminobenzoxazole analogues as potent and orally efficacious ChemR23 inhibitors

We previously reported 2-aminobenzoxazole analogue 1 as a potent ChemR23 inhibitor. The compound showed inhibitory activity against chemerin-induced calcium signaling through ChemR23 internalization in CAL-1 cells, which are cell lines of plasmacytoid dendric cells (pDCs). Furthermore, compound 2 inhibited chemotaxis of CAL-1 triggered by chemerin in vitro. However, we noted a difference in the ChemR23 response to our inhibitor between rodents and non-rodents in a previous study. To address this issue, we performed optimization of ChemR23 inhibitors using CAL-1 cells endogenously expressing human ChemR23 and conducted a pharmacokinetics study in cynomolgus monkeys. Various substituents at the 4-position of the benzoxazole ring exhibited potent in vitro bioactivity, while those at the 6-position were not tolerated. Among substituents, a carboxyl group was identified as key for improving the oral bioavailability in cynomolgus monkeys. Compound 38a with the acidic part changed from a tetrazole group to a 1,2,4-oxadiazol-5-one group to improve bioactivity and pharmacokinetic parameters exhibited inhibitory activity against chemerin-induced chemotaxis in vitro. In addition, we confirmed the ChemR23 internalization of pDCs by compound 38a orally administered to cynomolgus monkeys. These 2-aminobenzoxazole-based ChemR23 inhibitors may be useful as novel immunotherapeutic agents capable of suppressing the migration of pDCs, which are known to be major producers of type I interferons in the lesion area of certain autoimmune diseases, such as systemic lupus erythematosus and psoriasis.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2343-89-7 help many people in the next few years. Formula: C4H5FO2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem