Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 51-67-2, Name is Tyramine, molecular formula is C8H11NO, belongs to benzoxazole compound. In a document, author is Cho, Kyung-Ah, introduce the new discover, HPLC of Formula: C8H11NO.
Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation
Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have indicated that activation of lipoxygenase in mast cells positive regulates allergic inflammatory responses by generating leukotrienes and proinflammatory cytokines. In the present study, the effects of benzoxazole derivatives on the lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines, production of histamine and surface expression of co-stimulatory molecules on bone marrow-derived mast cells (BMMCs) were studied. The benzoxazole derivatives significantly reduced the expression of interleukin (IL)-1 beta, IL-6, IL-13, tumor necrosis factor-alpha, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS. Furthermore, histamine production was suppressed in BMMCs treated with LPS, or treated with phorbol-12-myristate-13-acetate/ionomycin. Benzoxazole derivatives marginally affected the surface expression of cluster of differentiation (CD)80 and CD86 on BMMCs in the presence of LPS, although LPS alone did not increase the expression of those proteins. Therefore, benzoxazole derivatives inhibited the secretion of proinflammatory cytokines in mast cells and may be potential candidate anti-allergic agents to suppress mast cell activation.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 51-67-2. HPLC of Formula: C8H11NO.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem