So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Shengran; Lin, Lin; Wang, Wenliang; Yan, Xinxin; Chen, Binggang; Jiang, Sangni; Liu, Sanrong; Ma, Xiaojing; Tian, Huayu; Yu, Xifei researched the compound: 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane( cas:33941-15-0 ).Related Products of 33941-15-0.They published the article 《Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery》 about this compound( cas:33941-15-0 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: aza crown ether locked polyethyleneimine gene transfection. We’ll tell you more about this compound (cas:33941-15-0).
We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem