Palladium-Catalyzed Direct Cyclopropylation of Heterocycles was written by Wu, Xiaojin;Lei, Chuanhu;Yue, Guizhou;Zhou, Jianrong. And the article was included in Angewandte Chemie, International Edition in 2015.Application of 132227-03-3 This article mentions the following:
Variously substituted 1,3-azoles (oxazole, benzoxazole, 4-methylthiazole, caffeine, etc.) and 2- and 3-cyanothiophenes were directly cyclopropylated with cyclopropyl iodides in the presence of a simple palladium catalyst. The relative configuration on the three-membered rings was retained in the products. In this process, the cyclopropyl-halide bond underwent concerted oxidative addition to palladium(0), and cyclopropyl radicals were not involved in the productive pathway. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Application of 132227-03-3).
5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Application of 132227-03-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem