4-(S-Methylsulfonimidoyl)benzonitrile (BD00975057) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
An efficient strategy was developed for the synthesis of 1,2-benzothiazines and isoquinolines I [R = H, 6-Me, 8-F, etc.; R1 = Me, Ph, NHPh, etc.; R2 = Me, t-Bu, 2-FC6H4, etc.; X = C, S(O)] via Rh-catalyzed annulative coupling of aryl-imines/sulfoximines with sulfoxonium ylides. This protocol was also extended for the synthesis of isoquinoline-N-oxides such as II [R3 = Me, Et; R4 = H, 6-t-Bu, 7-Cl, etc.; Ar = Ph, 2-MeC6H4, 4-FC6H4, etc.] and naphthoimidazo[1,2-a]pyridines III [R5 = H, 2-Me, 3-Cl, etc.] from ketoximes and 2-arylimidazo[1,2-a]pyridines resp.
Rhodium(III)-catalyzed annulative coupling between arenes and sulfoxonium ylides via C-H activation. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem