(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.
An oxidative coupling of NH-sulfoximines and arylsulfinates catalyzed by of I2 and H2O2 affords N-sulfonyl sulfoximines. The reaction proceeds under aerobic conditions in water at room temperature The merits of this protocol include mild metal-free reaction conditions, a green and cheap solvent, safe and simple operation, good yields, and a wide substrate scope.
I2-Catalyzed N-Sulfonylation of Sulfoximines with Sulfinates in Water at Room Temperature. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem