Zhu, Kai’s team published research in Organic Letters in 2020-03-06 | 13451-78-0

Organic Letters published new progress about Benzothiazoles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Recommanded Product: 5-Fluorobenzo[d]oxazole-2-thiol.

Zhu, Kai; Wang, Yi; Fang, Qi; Song, Zongqiang; Zhang, Fengzhi published the artcile< Enantioselective Synthesis of Axially Chiral Biaryls via Copper-Catalyzed Thiolation of Cyclic Diaryliodonium Salts>, Recommanded Product: 5-Fluorobenzo[d]oxazole-2-thiol, the main research area is iodo alkyl biphenyl thio benzoxazole preparation enantioselective; cyclic diaryliodonium salt mercaptobenzoxazole thiolation chiral copper catalyst; benzothiazole thio iodo alkyl biphenyl preparation enantioselective; mercaptobenzothiazole cyclic diaryliodonium salt thiolation chiral copper catalyst.

A chiral copper(II)-bisoxazoline-catalyzed enantioselective ring opening of cyclic diaryliodonium salts with heteroaryl thiols to give 2-((2′-iodo-6,6′-alkyl-[1,1′-biphenyl]-2-yl)thio)-5-benzo[d]oxazoles and 2-((2′-iodo-6,6′-alkyl-[1,1′-biphenyl]-2-yl)thio)-5-benzo[d]thiazoles I [R1 = 6-Me, 6-Cl, 6-OH, etc.; R2 = 6-Me, 6-Cl, 4.6-Me2, etc.; R3 = 2-pyridyl, 2-mercaptobenzoxazolyl, 5-Cl-mercaptobenzoxazol-2-yl, etc.] in excellent yields and enantioselectivities was reported. The products were further transformed into diverse enantiopure alkyl biaryl sulfides I [R1 = 6-Me; R2 = 6-Me; R3 = Me, i-Pr, Bn, etc.] which could be employed as chiral ligands.

Organic Letters published new progress about Benzothiazoles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13451-78-0 belongs to class benzoxazole, and the molecular formula is C7H4FNOS, Recommanded Product: 5-Fluorobenzo[d]oxazole-2-thiol.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem